[Treatment strategies of cytoreductive surgery plus intraperitoneal hyperthermic chemotherapy for gastric cancer with peritoneal metastasis: a systematic review].

Peritoneal metastasis in gastric cancer is associated with rapid disease progression. Hyperthermic intraoperative peritoneal chemotherapy (HIPEC) done immediately after cytoreductive surgery (CRS) has become an important treatment for peritoneal metastasis in gastric cancer patients. However, different treatment options for HIPEC exist with potential influence on survival rates and prognosis in patients, exist. These treatment options include open or closed abdomen technique, perfusion solution, number of catheters, temperature, duration, and drug regimens. This paper aims to provide more evidence on standardization of HIPEC treatment options and technologies by systematically reviewing different drug regimens and technical approaches. The study included 2 randomized controlled trials, 3 phase I/II clinical trials, 2 prospective cohort studies, and 34 retrospective cohort studies, involving 1511 patients. The most common HIPEC option is to dissolve 50-75 mg/m2 of Cisplatin and 30-40 mg/m2 of Mitomycin C in 3-4 L saline solution at 42-43℃. After gastrointestinal anastomosis, 2-3 catheters are used in the HIPEC system with a perfusion flow rate of 500 ml/min. The duration is 60-90 minutes. Anastomotic leakage was low in studies where HIPEC was performed after gastrointestinal anastomosis. The utilization of open HIPEC and a two-drug regimen resulted in improved overall survival rates. The future development of HIPEC aims to enhance tumor-specific therapy by optimizing various aspects, such as identifying the safest and most effective chemotherapy regimens, refining patient selection criteria, and improving perioperative care.

[Treatment of lumbar intervertebral disk prolapse by estradural injection of mailuoning and its influence on dynorphin A in cerebrospinal fluid].

OBJECTIVE: To explore the modulating effects of extradural injection of Mailuoning on analgesic function. METHODS: Twenty patients of lumbar intervertebral disk prolapse were treated by extradural injection of Mailuoning, the spontaneous release of dynorphin A (Dyn-A) in cerebrospinal fluid (CSF) before and after treatment were measured and compared with that of the 20 cases in the control group to determine the therapeutic effect of Mailuoning. RESULTS: After treatment, the concentration of Dyn-A in CSF in the treated group increased remarkably, but displayed no significant difference to normal healthy group (P > 0.05), while that in the control group there was significant difference between them (P < 0.01). CONCLUSION: Mailuoning has the modulatory effect on analgesia function and lumbar intervertral disk prolapse was treated by means of its Dyn-A elevating action.

[Correlative study between character of bending strength of callus and X-ray density of callus in fracture healing process].

OBJECTIVE: To set up an objective and non-injury method to estimate the fracture healing process. METHODS: X-ray films of 48 cases of adult fresh fracture, 50 cases of adult old fracture and 70 rabbits experimental fracture of tibia were analysed, through computer image processing. RESULTS: The bending strength of callus and the X-ray density of callus have an exponential correlation (P < 0.05). The X-ray density of callus increased coincidently with the fracture healing process. It also confirmed that there was a high correlation between the character of bending strength of callus and the X-ray density of callus. CONCLUSION: It provided an objective method to assess fracture healing treated by the integration of TCM and WM.

Treatment of forearm bone fractures by an integrated method of traditional Chinese and Western medicine.

Of 2221 forearm fractures (1300 left, 921 right) in adults (1167 men, 1043 women) treated from January, 1972, to December, 1982, 2117 were closed and 104 open fractures. The fractures are classified as follows: fracture of both radius and ulna, 1161 cases (52.3%); fracture of the ulna alone, 343 (15.4%); Monteggia fracture, 259 (11.7%); fracture of the radius alone, 222 (10%); and Galeazzi fracture, 236 (10.6%). For each type, the treatment consisted of closed reduction by manipulation, immobilization, and functional exercises. A total of 1054 cases of forearm fracture were followed for 0.5-6.5 years (average, 2.5 years). The results were excellent in 735 cases (69.7%); good, 153 (14.5%); fair, 79 (7.5%); and poor, 87 (8.3%). The time of bone union was from 21-258 days. Nonunion occurred in three cases. Anatomic observations were carried out in specimens of adult forearms, which showed that: the interosseous membrane is an important factor in maintaining the stability of the radius and ulna and is the anatomic basis for manipulative reduction by bone separation; the use of bone separator pads can maintain the normal tension of the interosseous membrane and the physiologic space between the radius and ulna. Stress analysis of the bone separator pads and splint immobilization suggests that treatment of forearm fracture by integrated traditional Chinese medicine and western medicine is simple, economical, relatively painless, and effective.(ABSTRACT TRUNCATED AT 250 WORDS)