ABSTRACT
Kokon Rohrbach-Berg is the first Austrian rehabilitation clinic exclusively built for children and teenagers aged 0-18. There are 77 beds for patients available at kokon Rohrbach-Berg, with an additional 67 beds for accompanying chaperones.We are specialized in the fields of mobilisation, cardiologic and pulmologic disorders as well as in mental health rehabilitation. Our focus lies on an integrative perception of children and teenagers' chronic illnesses.The rehabilitation program is designed around the specific needs of each child or teenager.Our interdisciplinary teams create individual therapy plans, offer child-friendly incentives to further develop independence and strive to improve participation in daily life.
Subject(s)
Adenoviridae Infections/complications , Adenoviridae Infections/diagnosis , Chlamydophila Infections/complications , Chlamydophila Infections/diagnosis , Paraproteinemias/complications , Paraproteinemias/diagnosis , Streptococcal Infections/complications , Streptococcal Infections/diagnosis , Adenoviridae/isolation & purification , Child, Preschool , Chlamydophila pneumoniae/isolation & purification , Humans , Male , Streptococcus pyogenes/isolation & purificationABSTRACT
Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder associated with defects in apoptosis, characterized by childhood onset of lymphadenopathy, splenomegaly, hyperimmunoglobulinemia, and autoimmune disease. ALPS is most frequently associated with a mutation in the cell death receptor Fas (CD95). Very rarely a mutation in caspase 10 is present. An increase of CD4/CD8 double negative T cells in the peripheral blood and lymph nodes is a feature characteristic of ALPS. Additionally, histiocytic proliferations resembling sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) were reported recently in patients with ALPS. In the rare cases with a caspase 10 mutation an accumulation of dendritic cells in lymphoid organs was noted. We describe a different, sarcoidosislike, histiocytic infiltration of lymph nodes that persisted for years in a girl, that was initially supposed to suffer from sarcoidosis, but was eventually diagnosed as ALPS, associated with a missense mutation in the intracellular death domain of Fas. This sarcoidosislike histologic picture extends the spectrum of histiocytic lymph node alterations observed in ALPS and alerts of a potential diagnostic pitfall.
