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Cir Cir ; 87(6): 662-666, 2019.
Article in English | MEDLINE | ID: mdl-31631192

ABSTRACT

OBJECTIVE: To evaluate the relationship between C reactive protein and procalcitonin levels and the appearance of post-operative intraabdominal infection, in patients with pancreaticoduodenectomy due to pancreatic cancer. METHOD: A prospective observational study, including 35 patients, was made. Procalcitonin and C reactive protein were measured before surgery, as well as 24, 48 and 72 h after the surgical procedure. Patients were divided in two groups, with and without intraabdominal infection. RESULTS: Six patients (17.1%) presented post-operative intraabdominal infection. Both, procalcitonin and C reactive protein, increased in all patients after surgery, but there were no significant differences between the two groups. However, the ratio between the C reactive protein concentrations on post-operative day 3 and the concentrations on post-operative day 1 was significantly increased in the group of patients with intraabdominal infection. The predictive positive value and the predictive negative value for this ratio were 60% and 95%, respectively, for a cut-off point of 2.3. CONCLUSIONS: The ratio between C reactive protein value on post-operative day 3 and the value on post-operative day 1 is a good predictor of post-operative intraabdominal infection after pancreaticoduodenectomy.


OBJETIVO: Evaluar la relación entre los valores de proteína C reactiva y de procalcitonina y la aparición de infección intraabdominal posoperatoria en pacientes con duodenopancreatectomía por cáncer de páncreas. MÉTODO: Estudio prospectivo observacional que incluye 35 pacientes. Ambos parámetros se midieron antes de la cirugía y a las 24, 48 y 72 horas de la intervención. Los pacientes se dividieron en dos grupos: con y sin infección intraabdominal. RESULTADOS: Seis pacientes (17.1%) tuvieron infección intraabdominal. Ambos parámetros aumentaron en todos los pacientes tras la cirugía, pero no hubo diferencias significativas entre los dos grupos. Sin embargo, el cociente entre los valores de proteína C reactiva en el día 3 y los valores en el día 1 de posoperatorio era significativamente mayor en los pacientes con infección intraabdominal, con un valor predictivo positivo del 60% y un valor predictivo negativo del 95%, para un punto de corte de 2.3. CONCLUSIONES: El cociente entre las concentraciones séricas de proteína C reactiva en el tercer día y en el primer día de posoperatorio es un buen predictor de infección intraabdominal posoperatoria después de una duodenopancreatectomía.


Subject(s)
C-Reactive Protein/analysis , Pancreatic Neoplasms/surgery , Pancreaticoduodenectomy , Postoperative Complications/blood , Postoperative Complications/diagnosis , Procalcitonin/blood , Abdomen , Aged , Female , Humans , Male , Middle Aged , Postoperative Complications/microbiology , Predictive Value of Tests , Prospective Studies
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