ABSTRACT
BACKGROUND: Rheumatic manifestations of genetic hemochromatosis are frequent with axial or peripheral arthropathies (mono-, oligo- or polyarticular). These manifestations are characterized by articular damage and osteoporosis. AIM: To review the rheumatic manifestations of genetic hemochromatosis. METHODS: A narrative review of literature. RESULTS: The diagnosis should be brought to mind when we discover arthropathy resembling degenerative joint disease with involvement of unusual articular sites, almost identical to the arthropathy in calcium pyrophosphate dihydrate crystals deposition disease (chondrocalcinosis). CONCLUSION: There is a significant bone loss in HC that cannot solely be explained by hypogonadism or cirrhosis and must lead to measure bone mass density to each patient with HC.
Subject(s)
Hemochromatosis/complications , Rheumatic Diseases/diagnosis , Rheumatic Diseases/etiology , Bone Diseases/diagnosis , Bone Diseases/etiology , Bone Diseases/genetics , Bone and Bones/diagnostic imaging , Bone and Bones/pathology , Cartilage, Articular/diagnostic imaging , Cartilage, Articular/pathology , Diagnosis, Differential , Diagnostic Techniques and Procedures , Genetic Testing , Hemochromatosis/diagnosis , Hemochromatosis/genetics , Hemochromatosis/therapy , Humans , Radiography , Rheumatic Diseases/genetics , Rheumatic Diseases/therapyABSTRACT
Gout is one of the oldest and better understood among rheumatic diseases. It is characterized by chronic hyperuricemia and recurrent attacks of acute arthritis provoked by release of sodium urate crystals into joints. The manifestations of Gout can be abolished by lifelong urate-lowering therapy maintainine serum urate levels under 360 mmol/l. The management of a minority of patients, including those with renal impairment, is difficult and often unsatisfactory because of restricted treatment options. In this paper; the current options for treating hyperuricemia are first discussed then followed by new approches.
Subject(s)
Gout Suppressants/therapeutic use , Gout/drug therapy , Gout Suppressants/pharmacology , HumansABSTRACT
Industrial accidents causing lumbar back strain are frequent and are of major causes of absenteeism. For this purpose, we tried in this study to assess the prevalance of such accidents, to determine the circumstances of their occurence and to point out the various risk professions. For this, we analysed 242 files of lumbar back pathology industrial accidents related. The latter files have been examined by the Tunis medical board authorized to set out the permanent disability rate resulting from industrial accidents and occupational diseases. We noticed a marked male predominance 58% of patients were aged between 41 and 50 years. We observed a predisposition in 19% of all cases. The professional category of operators is mainly concerned. These accidents most frequently occur in the morning at the site of work, often due to the handling of heavy loads. They cause lesions of variable importance, such as slipped disc hernia in 40% of cases. The average duration of absenteeism resulting from lumbar strain is of 237 days a year per patient. After-effects are frequent, notably those of spinal pains and lumbar stiffness. The average rate of permanent partial disability is of 8% (0-45%).