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Catheter Cardiovasc Interv ; 53(4): 480-8, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11514998

ABSTRACT

Thirty-two patients presenting with varied coronary syndromes and anatomy were treated with a new coronary multisleeve drug delivery coronary stent (QuaDS-QP-2) containing up to 4,000 microg of a taxol-derived lipophilic microtubule inhibitor (QP2). The device was successfully implanted in 32 patients who have been followed for up to 2 years. Twenty-five patients have undergone stress ECHO or SPECT Thallium and all are currently asymptomatic. Thirteen patients have already been restudied angiographically, by IVUS and/or by SPECT Thallium testing and are detailed in this report. Angiographic, IVUS, and SPECT Thallium have been controlled at a mean of 11.2 months (range, 6-15 months) in this 13-patient cohort. Although all 13 QuaDS-QP-2 (QDES) stents were angiographically and IVUS patent, two reinterventions have been required in the 32-patient study group thus far, both relate to either new disease or to distal, small-vessel disease beyond the stent. There was no evidence of significant proliferation in the QDES devices. On the basis of this preliminary data and a European pilot study, a controlled randomized trial (SCORE) is currently in progress in western Europe.


Subject(s)
Infusion Pumps, Implantable , Registries , Stents , Adult , Aged , Angiography , Cohort Studies , Coronary Disease/diagnostic imaging , Female , Follow-Up Studies , Humans , Male , Middle Aged , Recurrence , Tomography, Emission-Computed, Single-Photon , Ultrasonography, Interventional
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