ABSTRACT
Probe electrospray ionization mass spectrometry (PESI-MS) is an ambient ionization-based mass spectrometry method that surpasses the original electrospray ionization technique in features such as the rapidity of analysis, simplicity of the equipment and procedure, and lower cost. This study found that the PESI-MS system with machine learning has the potential to establish a lipid-based diagnosis of breast cancer with higher accuracy, using a simpler approach. Rapid mass spectrometry for breast cancer.
Subject(s)
Biomarkers, Tumor/metabolism , Breast Neoplasms/diagnosis , Breast/metabolism , Lipid Metabolism , Spectrometry, Mass, Electrospray Ionization , Biopsy , Breast/pathology , Breast Neoplasms/metabolism , Breast Neoplasms/pathology , Case-Control Studies , Female , Humans , Logistic Models , Sensitivity and SpecificityABSTRACT
One hundred ninety-eight mandibular first molars, 198 mandibular second molars, and 122 mandibular third molars, extracted from 99 Indian skulls were examined for the number of dental roots. The number of mandibular molar roots is increased by the appearance of the distolingual root, accessory lingual root, and bifurcation of the mesial root. The bifurcation of the mesial root was investigated in teeth in which it was more than 1/3 and less than 1/3 (apical bifurcation) of the root length. The following results were obtained. The numbers of the roots including apical bifurcation of the mesial root were 2, 3 and 4 in 72.7%, 26.8% and 0.5%, respectively, of the first molars; 1, 2 and 3 in 17.7%, 76.8% and 5.6%, respectively, of the second molars; and 1, 2 and 3 in 16.4%, 77.1% and 5.8%, respectively, of the third molars. The numbers of dental roots excluding apical bifurcation of the mesial root were 2 and 3 in 99.0% and 1.0%, respectively, of the first molars; 1, 2 and 3 in 17.7%, 81.8% and 0.5%, respectively, of the second molars; and 1, 2 and 3 in 16.4%, 77.1% and 5.8%, respectively, of the third molars.
Subject(s)
Molar/anatomy & histology , Tooth Root/anatomy & histology , Asian People , Humans , India , Mandible , White PeopleABSTRACT
In recent years, with the development of diagnostic procedures, the number of cases of early carcinoma of the gall bladder has been seen to gradually increase. In this paper, 8 cases of early gall bladder carcinoma have been evaluated, using a diagnostic approach. Cholecystolithiasis was the complication in 6 cases, and abdominal pain was seen as the most common symptom. Findings by various image diagnoses, such as ultrasonography, DIC, ERCP, and CT scan are described and discussed with a review of literature. Ultrasonography was considered to be the most useful tool for the detection and diagnosis of an early carcinoma of the gall bladder. A survey is thought to be required, involving the cases that have accumulated throughout the entire nation.
Subject(s)
Gallbladder Neoplasms/diagnosis , Adenocarcinoma/complications , Adenocarcinoma/diagnosis , Adenocarcinoma/pathology , Adenocarcinoma, Papillary/complications , Adenocarcinoma, Papillary/diagnosis , Adenocarcinoma, Papillary/pathology , Aged , Aged, 80 and over , Cholangiopancreatography, Endoscopic Retrograde , Cholelithiasis/complications , Female , Gallbladder Neoplasms/complications , Gallbladder Neoplasms/pathology , Humans , Male , Middle Aged , Tomography, X-Ray Computed , UltrasonographyABSTRACT
Sialylated Lewis (S-Lex) has been studied histologically and serologically in stomach cancer by the CSLEX1 monoclonal antibody. S-Lex was expressed in 73.9% of 46 stomach cancer tissues, 29.4% of metaplastic parts adjacent to cancer, and none of six gastric ulcer tissues including metaplasia. Serologically positive percentages were as follows: 26.0% of 100 stomach cancers, 0.9% of 322 benign diseases, and 0.7% of 280 healthy donors in the sera, as well as 72.4% of 29 ascites of stomach cancers and 5.3% of 17 effusions of benign diseases. These findings demonstrate that S-Lex possesses a potential usefulness as a tumor marker in stomach cancer.