1.
J Org Chem
; 89(3): 1552-1555, 2024 Feb 02.
Article
in English
| MEDLINE
| ID: mdl-38262918
ABSTRACT
A Pd-catalyzed formal [4 + 1] cycloaddition reaction of sulfur ylides and in situ-generated Pd-stabilized zwitterions offers a convenient route to a series of functionalized proline derivatives. The utility of this method is demonstrated by a gram-scale synthesis and chemoselective functionalization of a proline-based derivative.