ABSTRACT
Rituximab is a monoclonal antibody directed against B cells and is being increasingly used for various renal indications. Acute dermatologic manifestations such as urticaria are well known to occur during rituximab infusion. Here, we report the case of a 53- year-old female who was treated with rituximab for membranous nephropathy and developed an exanthematous rash, which progressed with a further dose of rituximab and was diagnosed as urticarial dermatitis. A review of literature showed that urticarial dermatitis following rituximab therapy has been seldom reported and identification of this complication is very important to avoid giving further doses and thus, increasing the severity of lesions.
Subject(s)
Drug Eruptions/etiology , Glomerulonephritis, Membranous/drug therapy , Immunologic Factors/adverse effects , Rituximab/adverse effects , Skin/drug effects , Urticaria/chemically induced , Drug Eruptions/diagnosis , Drug Eruptions/drug therapy , Female , Glomerulonephritis, Membranous/diagnosis , Glomerulonephritis, Membranous/immunology , Glucocorticoids/therapeutic use , Histamine Antagonists/therapeutic use , Humans , Middle Aged , Skin/pathology , Treatment Outcome , Urticaria/diagnosis , Urticaria/drug therapyABSTRACT
Drug induced hypersensitivity syndrome has been reported to a variety of drugs. Reactivation of herpes viruses is associated with relapse of symptoms even as late as five weeks after stopping the inciting drug. We report here a case of drug hypersensitivity with CMV reactivation which was treated successfully.