Subject(s)
Abdominal Injuries , Adrenal Gland Diseases , Wounds, Nonpenetrating , Humans , Hemorrhage/diagnostic imaging , Hemorrhage/etiology , Adrenal Gland Diseases/diagnostic imaging , Adrenal Gland Diseases/etiology , Wounds, Nonpenetrating/complications , Wounds, Nonpenetrating/diagnostic imaging , Abdominal Injuries/complications , Abdominal Injuries/diagnostic imaging , Retrospective StudiesABSTRACT
AIMS: Iron is an important metal ion as a biocatalyst on the other hand iron overload causes various diseases. Iron overload can result in fibrosis and hepatocellular carcinoma with various pathophysiological mechanisms, including oxidative damage in the liver. Therefore; in this study the effects of ozone and selenium -whose antioxidant properties are known- were evaluated in liver injury induced by iron overload. MATERIALS AND METHODS: Iron overload model was provided by intraperitoneal administration of 88â¯mg/kg iron dextrate for 4â¯weeks. After iron dextran administration, ozone and selenium administrations were made for 3â¯weeks. From the obtained blood and tissue samples total oxidant status (TOS) and total antioxidant status (TAS) were determined and histopathological examination was performed in liver tissue samples. KEY FINDINGS: In rats with iron overload, the lowest mean serum TOS was observed in the selenium administration group. The highest tissue TOS means and the lowest tissue TAS means were determined in the group in which ozone and selenium were administrated together. When histopathological data were evaluated, the presence of increased apoptosis in the ozone group compared to the iron group (pâ¯=â¯0.019) and selenium group (pâ¯=â¯0.019) was noted. Similarly, increased periportal inflammation (pâ¯=â¯0.001) and fibrosis (pâ¯=â¯0.005) were observed in the ozone group compared to the selenium group. SIGNIFICANCE: In iron-induced liver damage, ozone was thought to be effective by decreasing ROS, but contrary to expectations, it was observed that it may negatively affect the picture by showing synergistic effect. However, the effects of selenium on both serum and tissue levels are promising.
Subject(s)
Iron Overload/drug therapy , Liver/injuries , Ozone/pharmacology , Selenium/pharmacology , Animals , Antioxidants/administration & dosage , Antioxidants/metabolism , Antioxidants/pharmacology , Female , Inflammation/drug therapy , Inflammation/pathology , Iron Overload/complications , Liver/drug effects , Liver Cirrhosis/drug therapy , Liver Cirrhosis/etiology , Oxidative Stress/drug effects , Ozone/administration & dosage , Rats , Rats, Wistar , Reactive Oxygen Species/metabolism , Selenium/administration & dosageABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Wandering Spleen/diagnostic imaging , Intestines/abnormalities , Intestines/diagnostic imaging , Tomography, X-Ray ComputedSubject(s)
Digestive System Abnormalities/diagnostic imaging , Intestinal Volvulus/diagnostic imaging , Spleen/diagnostic imaging , Wandering Spleen/diagnostic imaging , Digestive System Abnormalities/pathology , Female , Humans , Intestinal Volvulus/pathology , Middle Aged , Spleen/anatomy & histology , Tomography, X-Ray Computed/methods , Torsion Abnormality/diagnostic imaging , Wandering Spleen/complications , Wandering Spleen/etiologyABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Echinococcosis/diagnostic imaging , Low Back Pain/etiology , Urinary Tract Infections/diagnostic imaging , Urinary Tract Infections/diagnosis , Albendazole/therapeutic use , Tomography, Emission-Computed , Urinalysis , Urine/microbiologyABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Wandering Spleen/diagnostic imaging , Hypogastric Plexus/physiopathology , Splenectomy , Abdominal Pain/etiologySubject(s)
Wandering Spleen , Adult , Female , Humans , Magnetic Resonance Imaging , Wandering Spleen/diagnostic imagingSubject(s)
Abscess/diagnostic imaging , Anus Diseases/diagnostic imaging , Colonoscopy/methods , Echinococcosis/diagnostic imaging , Magnetic Resonance Imaging/methods , Abscess/surgery , Adult , Anus Diseases/surgery , Diagnosis, Differential , Echinococcosis/surgery , Emergency Service, Hospital , Female , Humans , Inflammation/diagnostic imaging , Inflammation/physiopathology , Severity of Illness Index , Treatment OutcomeABSTRACT
OBJECTIVES: In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellular carcinoma cell line Hep3B was chosen as a model for investigation of LPS toxicity and the effect of EGCG on LPS-exposed cells. MATERIALS AND METHODS: The Hep3B human hepatoma cells were used for this study. The cytotoxic effects of chemicals (EGCG and LPS), AST and ALT levels, SOD and CAT activities, GSH-Px level and TNF-alpha and IL-6 levels were detected by using different biochemical and molecular methods. LPS and EGCG were applied to cells at various times and doses. RESULTS: The highest treatment dose of EGCG (400 µM) led to a dramatic decrease in SOD level and increase in CAT and GSH levels. Additionally, the highest dose of EGCG also led to a dramatic increase in TNF-alpha and IL-6 levels. On the other hand, effective doses of EGCG (200 and 100 µM) normalized all related parameters levels. CONCLUSION: LPS caused hepatotoxicity, but interestingly, a high dose of EGCG was found to be a cytotoxic agent in this study. However, other two doses of EGCG led to a decrease in both inflammatory cytokine levels and antioxidant enzyme levels. Further studies should examine the effect of EGCG on secondary cellular signaling pathways.
ABSTRACT
OBJECTIVE: Our aim was to report the importance of an awareness of renal artery variations if surgical procedures are indicated in this region. Presentation and Intervention: A 41-year-old female patient was admitted to our hospital for preoperative staging of the rectum carcinoma. A computed tomography (CT) scan clearly revealed the presence of normally positioned small right and left renal arteries, and a large aberrant renal artery originating from the distal abdominal aorta in a case with a horseshoe kidney (HSK). A multidetector CT angiography was performed using a 256-detector row CT scanner to obtain an image of vascular structures and associated pathologies. CONCLUSION: In this patient with HSK, the left renal vein compression was unusual and the CT examination provided a good delineation of vascular and urinary tract anomalies.
Subject(s)
Fused Kidney/diagnostic imaging , Fused Kidney/pathology , Renal Veins/diagnostic imaging , Renal Veins/pathology , Adult , Female , Humans , Multidetector Computed TomographyABSTRACT
Abstract Helicobacter pylori infection is usually acquired in early childhood and it can persist throughout life without antibiotic treatment. This study aimed to compare the accuracy of the noninvasive H. pylori Stool Antigen Test-applied on the stool samples with the invasive gold standart Rapid Urease Test-applied on the gastric biopy samples of patients with upper gastrointestinal complaints. After endoscopy, biopsy and stool specimens were taken in 122 patients. The infection was detected with rapid urease test which is accepted as gold standart test. Rapid, one-step H. pylori card test was applied to all patients stool specimens. In this study 106 of the 122 patients (86.8%) were positive for H. pylori infection, while 16 of the 122 patients (13.2%) were negative. H. pylori card test was negative in 13 of the 16 patients and was positive in 98 of the 106. The sensitivity, specifity, positive and negative predictive values were 92.45%, 81.25%, 97.02%, and 61.90%, respectively. H. pylori card test is rapid, easy, noninvasive and inexpensive methods for detection H. pylori infection. This test showed high sensitivity and specificity. Additionally, it may be a good alternative to invasive tests for the detection of H. pylori infections especially in children.
Subject(s)
Humans , Antigens, Bacterial/analysis , Feces/microbiology , Gastrointestinal Diseases/diagnosis , Helicobacter pylori/isolation & purification , Feces/chemistry , Predictive Value of Tests , Sensitivity and SpecificityABSTRACT
Helicobacter pylori infection is usually acquired in early childhood and it can persist throughout life without antibiotic treatment. This study aimed to compare the accuracy of the noninvasive H. pylori Stool Antigen Test-applied on the stool samples with the invasive gold standart Rapid Urease Test-applied on the gastric biopy samples of patients with upper gastrointestinal complaints. After endoscopy, biopsy and stool specimens were taken in 122 patients. The infection was detected with rapid urease test which is accepted as gold standart test. Rapid, one-step H. pylori card test was applied to all patients stool specimens. In this study 106 of the 122 patients (86.8%) were positive for H. pylori infection, while 16 of the 122 patients (13.2%) were negative. H. pylori card test was negative in 13 of the 16 patients and was positive in 98 of the 106. The sensitivity, specifity, positive and negative predictive values were 92.45%, 81.25%, 97.02%, and 61.90%, respectively. H. pylori card test is rapid, easy, noninvasive and inexpensive methods for detection H. pylori infection. This test showed high sensitivity and specificity. Additionally, it may be a good alternative to invasive tests for the detection of H. pylori infections especially in children.
Subject(s)
Antigens, Bacterial/analysis , Feces/microbiology , Gastrointestinal Diseases/diagnosis , Helicobacter pylori/isolation & purification , Feces/chemistry , Humans , Predictive Value of Tests , Sensitivity and SpecificityABSTRACT
Cystic and solid tumors of the ovary are rare during the newborn period and infancy. We present the case of a term female infant born to a mother of 28 years of age and found to have a cystic abdominal mass through prenatal sonographic evaluation in the third trimester. The complex cyst was also demonstrated by postnatal abdominal ultrasonography. Laparotomy revealed a large cystic mass with a torsed right ovary. Pathologic examination of cyst revealed hemorrhagic necrosis with ovarian torsion.
Subject(s)
Ovarian Cysts/congenital , Ovarian Cysts/diagnostic imaging , Torsion Abnormality/congenital , Torsion Abnormality/diagnostic imaging , Ultrasonography, Prenatal , Adult , Female , Humans , Infant, Newborn , PregnancyABSTRACT
OBJECTIVES: In this paper we describe sonoelastography findings for idiopathic granulomatous mastitis (IGM), the clinical and radiological features of which often mimic those of breast carcinoma. MATERIALS AND METHODS: In this retrospective study, sonoelastography findings for patients with pathologically proved IGM were studied. Twenty-seven patients with pathologically proved IGM were enrolled in the study. All were female, and the mean age was 37.81 years (standard deviation 7.10 years; range 24 to 56 years). Elasticity scores (ES), strain ratios (SR), and elastic diameters (ED) were evaluated for the lesions. RESULTS: Ten lesions (37.0 %) were diffuse, six (22.2 %) were tubular, six (22.2 %) were a mass, and five (18.5 %) were cystic in appearance on ultrasonography. On sonoelastography, mean ES ± standard deviation was 1.66 ± 0.55 (between 1.00 and 3.00); mean SR ± standard deviation was 1.10 ± 0.79 (between 0.29 and 4.00). ED was no different between grey-scale and sonoelastogram images. CONCLUSIONS: The features of idiopathic granulomatous mastitis suggest it is benign in nature.
Subject(s)
Elasticity Imaging Techniques , Granulomatous Mastitis/diagnosis , Adult , Elasticity , Female , Humans , Middle Aged , Retrospective StudiesSubject(s)
Colonoscopy/instrumentation , Foreign Bodies/therapy , Rectum , Urinary Catheters , Aged , Humans , MaleABSTRACT
OBJECTIVE: Many surgeons face difficulties during single-incision laparoscopic cholecystectomy (SILC) surgery and are forced to use an additional port. We compared the results of a technique that we developed with SILC. MATERIAL AND METHODS: Fifty-four patients who were diagnosed with chronic cholelithiasis were prospectively randomized and divided into two groups. An additional 5-mm port (MCAP: with an additional port using a multi-channel device through the umbilicus) was placed in the subxiphoid area instead of a transabdominal suspension suture in one group of patients. The other group was operated on with the SILC technique. The demographic and surgical data of the patients were compared. RESULTS: The MCAP technique shortened the surgery duration by more than half (MCAP: 35.0±12.3, SILC: 79.1±27.7 min) (p<0.05). No difference was found between the two methods in terms of estimated blood loss, length of hospitalization, postoperative day 1 and 7 visual analog scale scores, need for analgesia in the postoperative period, and rate of changing to another technique due to inadequacy of the surgical technique. CONCLUSION: MCAP is as safe as SILC for cholecystectomy and is easier for the surgeon to perform.