Copper phthalocyanines as a mode-locker in an Er-doped fiber laser.

We demonstrate a mode-locked erbium-doped fiber laser (EDFL) utilizing copper phthalocyanines (CuPc) as a saturable absorber (SA) for the first time, to the best of our knowledge. The investigated SA was prepared using a simple, low-cost and straightforward technique, whereby the CuPc powder was embedded into polyvinyl alcohol (PVA) to form a thin film. The thin film acted as a mode-locker when it was incorporated into the EDFL cavity to produce output pulses at a repetition rate of 1.8 MHz with a pulse duration of 1.98 ps. The frequency spectrum showed a signal-to-noise ratio as high as 55 dB, which indicates the stability of the mode-locking operation. To the best of our knowledge, this is the first work to report using CuPc as a mode-locker.

Domain-wall dark pulse generation with SMF-GIMF-SMF structure as artificial saturable absorber.

We experimentally demonstrated the generation of domain-wall dark pulse in an Erbium-doped fiber laser using the combination of a 10 cm graded index multimode fiber sandwiched by single mode fibers as artificial saturable absorber. The interaction of phase difference in grade index multimode fiber allowed the stable dual-wavelength oscillation in the cavity. The dual-wavelength centered at 1567.2 nm and 1569.4 nm produces the topological defect in temporal domain and achieved a dark pulse formation with repetition rate of 21.5 MHz. The highest average pulse energy is calculated as 769.6 pJ with pulse width of 5 ns. Throughout the operating pump power range, the average pulse energy and output power increase linearly, with R2 of 0.9999 and achieved the laser efficiency of 9.33%. From the measurement in frequency domain, the signal-to-noise ratio is measured as 49 dB. As compared to reported DW dark pulse works, the proposed structure only required a short length of multimode fiber, which allowed the domain-wall dark pulse to achieve higher pulse repetition rate. The venture of domain wall dark pulse is potentially to pave the foundation toward sustainable industrial growth.

Sodium carbonate modulated ultrashort mode-locked stretched pulses in an erbium-doped fiber laser.

In this paper, we propose a new, to the best of our knowledge, saturable absorber (SA) based on sodium carbonate (N a 2 C O 3) for producing an ultrafast mode-locked stretched pulse in a passively erbium-doped fiber laser at near-zero dispersion. The solid film of a N a 2 C O 3-SA was fabricated by the drop-casting method using polyvinyl alcohol as a host polymer. The modulation depth of the proposed SA, which was measured by a balanced twin detector technique, was 2.3% with saturation intensity of 181M W/c m 2. The mode-locking operation of the EDFL-based N a 2 C O 3-SA was observed at a pump power of 117 mW. A stable stretched pulse was generated by using the proposed N a 2 C O 3-SA. The laser can generate pulses with a repetition rate and duration of 1.87 MHz and 820 fs, respectively, within a bandwidth of 6.6 nm. The single pulse energy reaches up to 5 nJ, which is equivalent to the average output power of 9.3 mW. Finally, to the best of our knowledge, this is the first report on using the N a 2 C O 3-SA for generating a stretched-pulse mode-locked fiber laser.

Review of Microbottle Resonators for Sensing Applications.

Microbottle resonators (MBR) are bottle-like structures fabricated by varying the radius of an optical fiber. MBRs can support whispering gallery modes (WGM) by the total internal reflection of the light coupled into the MBRs. MBRs have a significant advantage in sensing and other advanced optical applications due to their light confinement abilities in a relatively small mode volume and having high Q factors. This review starts with an introduction to MBRs' optical properties, coupling methods, and sensing mechanisms. The sensing principle and sensing parameters of MBRs are discussed here as well. Then, practical MBRs fabrication methods and sensing applications are presented.

Single and Bunch Soliton Generation in Optical Fiber Lasers Using Bismuth Selenide Topological Insulator Saturable Absorber.

In this work, we present the generation of two distinct types of soliton pulses using a Bismuth Selenide (Bi2Se3) saturable absorber (SA) synthesized in our laboratory. The soliton pulses were generated in two different laser cavity configurations, resulting in two types of solitons: a soliton pulse with Kelly sidebands and a bunched soliton pulse with peak-dip sidebands. Both solitons operated at the fundamental repetition rate-23.3 MHz (for the soliton with Kelly sidebands) and 13 MHz (for the bunched soliton with peak-dip sidebands). We observed that the accumulation of nonlinear phase shift from the added single mode fiber (SMF) split the single soliton pulse into 44 pulses in a bunched oscillation envelope. At the same time, peak-dip sidebands were imposed on the bunched soliton spectrum due to constructive and destructive interferences between soliton pulse and dispersive waves. The measured pulse width for both solitons were 0.63 ps (for the soliton with Kelly sidebands) and 1.52 ps (for the bunched soliton with peak-dip sidebands), respectively. Our results demonstrate the potential of Bi2Se3 SAs in generating different types of soliton pulses, which could have potential applications in various areas of optical communication and spectroscopy.

Dissipative Soliton Mode-Locked Erbium-Doped Fiber Laser Using Nb2AlC Nanomaterial Saturable Absorber.

We report the fabrication of an erbium-doped fiber-based saturable absorber (SA) of niobium aluminium carbide (Nb2AlC) nanomaterial that can generate a dissipative soliton mode-locked pulse. Stable mode-locked pulses operating at 1530 nm with repetition rates of 1 MHz and pulse widths of 6.375 ps were produced using polyvinyl alcohol (PVA) and the Nb2AlC nanomaterial. A peak pulse energy of 7.43 nJ was measured at 175.87 mW pump power. In addition to providing some useful design suggestions for manufacturing SAs based on MAX phase materials, this work shows the MAX phase materials' immense potential for making ultra-short laser pulses.

Skin lesion classification using multi-resolution empirical mode decomposition and local binary pattern.

Skin cancer is the most common type of cancer in many parts of the world. As skin cancers start as skin lesions, it is important to identify precancerous skin lesions early. In this paper we propose an image based skin lesion identification to classify seven different classes of skin lesions. First, Multi Resolution Empirical Mode Decomposition (MREMD) is used to decompose each skin lesion image into a few Bidimensional intrinsic mode functions (BIMF). MREMD is a simplified bidimensional empirical mode decomposition (BEMD) that employs downsampling and upsampling (interpolation) in the upper and lower envelope formation to speed up the decomposition process. A few BIMFs are extracted from the image using MREMD. The next step is to locate the lesion or the region of interest (ROI) in the image using active contour. Then Local Binary Pattern (LBP) is applied to the ROI of the image and its first BIMF to extract a total of 512 texture features from the lesion area. In the training phase, texture features of seven different classes of skin lesions are used to train an Artificial Neural Network (ANN) classifier. Altogether, 490 images from HAM10000 dataset are used to train the ANN. Then the accuracy of the approach is evaluated using 315 test images that are different from the training images. The test images are taken from the same dataset and each test image contains one type of lesion from the seven types that are classified. From each test image, 512 texture features are extracted from the lesion area and introduced to the classifier to determine its class. The proposed method achieves an overall classification rate of 98.9%.

Nanosecond Q-switched laser with PEDOT: PSS saturable absorber.

We demonstrate deployment of the nonlinear saturable absorption property of the organic material poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT: PSS) for pulse generation in the near-infrared region. The saturable absorber (SA) film was made using a straightforward process of depositing a layer of the PEDOT: PSS material onto a polyvinyl alcohol (PVA) film. The prepared SA was inserted into an erbium-doped fiber laser cavity as a Q-switcher to produce laser pulses with a maximum pulse rate of 92.75 kHz, minimum pulse duration of 912 ns, and highest pulse energy of 222.83 nJ. Results showed that PEDOT: PSS/PVA SA could become a promising SA for various laser applications. To our knowledge, this is the first time that PEDOT: PSS/PVA has been utilized as a SA to produce a stable Q-switched laser in 1.55 µm.

Self-starting triple-wavelength vector dark soliton with a bismuth-doped fiber saturable absorber.

We report on the generation of a triple-wavelength vector dark soliton in an all-fiber ring cavity of erbium-doped fiber laser mode-locked with a bismuth-doped fiber saturable absorber. The formation of the triple-wavelength vector dark soliton is due to the cross-phase coupling derived from the cavity birefringence. The mode-locked laser operated at a 1.89 MHz repetition rate with a 335 ns pulse width, and its robustness is confirmed.

Precursors to non-invasive clinical dengue screening: Multivariate signature analysis of in-vivo diffuse skin reflectance spectroscopy on febrile patients in Malaysia.

Dengue diagnostics have come a long way. Attempts at breaking away from lab-oriented dengue detection, such as NS1 antigen, IgM or IgG antibodies detection have extensively received numerous coverage. As a result, rapid detection tests (RDTs) have started to gain inroads in medical practice. Rapid detection tests notwithstanding, analysis of blood serum is still a relatively complicated task. This includes the necessity of phlebotomy, centrifugation for blood serum, and other reagent-based tests. Therefore, a non-invasive method of dengue detection was considered. In this study, we present the utility of diffuse reflectance skin spectroscopy (bandwidth of 200-2500nm) on the forearm during the triaging period for dengue screening potential. This is performed with multivariate analysis of 240 triaged febrile/suspected dengue patients. The data is then scrutinized for its clinical validity to be included as either confirmed or probable dengue, or a control group. Based on discriminant analysis of several data normalization models, we can predict the patients' clinical dengue-positivity at ranges of accuracy between ~93-98% depending on mode of the data, with a probably optimal sensitivity and specificity to the clinical diagnosis of ~89% and ~100% respectively. From the outcomes of this study, we recommend further trials with cautious optimism. With these findings, it is hoped that the elusive non-invasive detection of tropical diseases may gain platform in the near future.

Nanosecond pulse laser generation at 1.55 and 2 µm regions by integrating a piece of newly developed chromium-doped fiber-based saturable absorber.

This paper demonstrated the nanosecond pulse laser operation at 1.55 and 2 µm wavelength regions using a newly develop chromium-doped fiber (CrDF) as a saturable absorber (SA) to convert efficiently continuous-wave laser operation to nanosecond pulse laser operation. The laser uses an erbium-doped fiber (EDF) and thulium-doped fiber as the gain medium. A piece of 10 cm long CrDF was integrated into both laser cavities to generate nanosecond pulse laser operation. In 1.55 region generation, an additional single-mode fiber (SMF) 100 m long was added into the EDF laser cavity. Stable pulse generation occurred at a repetition rate of 1 MHz with a pulse width of 432 ns and a signal-to-noise ratio (SNR) of 66 dB. The highest peak power of 24 mW was obtained at 142 mW pump power. In 2 µm region generation, the obtained repetition rate was 10 MHz with a pulse width and SNR of 59 ns and 41 dB, respectively. The highest peak power was only 8.3 mW. By looking into the findings, the newly developed CrDF SA has a potential to be further enhanced toward better generation of ultrashort pulse fiber lasers.

Nanosecond passively Q-switched fibre laser using a NiS2 based saturable absorber.

Q-switched pulse laser generation is successfully demonstrated in both Erbium-doped fibre laser (EDFL) and Thulium-doped fibre laser (TDFL) cavities by employing Nickel disulfide (NiS2) as a saturable absorber (SA). Q-switched pulse laser operation at 1.55 µm and 2.0 µm is obtained at low pump power levels of 37 mW and 48 mW, respectively. For the EDFL, stable passively Q-switched laser output at a wavelength of 1561.86 nm is achieved, with a minimum pulse duration of 237 ns and a repetition rate of 243.9 kHz. For the TDFL, the centre wavelength of the laser output is 1915.5 nm, with a minimum pulse duration of 505 ns and a repetition rate of 214.68 kHz. NiS2 is used as SA for Q-switched laser generation over a broadband wavelength for the first time.

Investigation of Surface Plasmon Resonance (SPR) in MoS2- and WS2-Protected Titanium Side-Polished Optical Fiber as a Humidity Sensor.

In this paper, we report the effects of a side-polished fiber (SPF) coated with titanium (Ti) films in different thicknesses, namely 5 nm, 13 nm, and 36 nm, protected by a thin layer of transition metal dichalcogenides (TMDCs) such as molybdenum disulfide (MoS2) and tungsten disulfide (WS2), which provide ultra-sensitive sensor-based surface plasmon resonance (SPR) covering from the visible to mid-infrared region. The SPF deposited with Ti exhibits strong evanescent field interaction with the MoS2 and WS2, and good optical absorption, hence resulting in high-sensitivity performance. Incremental increases in the thickness of the Ti layer contribute to the enhancement of the intensity of transmission with redshift and broad spectra. The findings show that the optimum thickness of Ti with 36 nm combined with MoS2 causes weak redshifts of the longitudinal localized surface plasmon resonance (LSPR) mode, while the same thickness of Ti with WS2 causes large blueshifts. The redshifts are possibly due to a reduced plasmon-coupling effect with the excitonic region of MoS2. The observed blueshifts of the LSPR peak position are possibly due to surface modification between WS2 and Ti. Changing the relative humidity from 58% to 88% only elicited a response in Ti/MoS2. Thus, MoS2 shows more sensitivity on 36-nm thickness of Ti compared with WS2. Therefore, the proposed fiber-optic sensor with integration of 2D materials is capable of measuring humidity in any environment.

Ultrashort pulse generation with an erbium-doped fiber laser ring cavity based on a copper oxide saturable absorber.

A soliton mode-locked erbium-doped fiber (EDF) laser has been experimentally demonstrated using copper oxide (CuO) thin film as a saturable absorber (SA). The dispersion of the EDF cavity including the CuO-SA was balanced by a suitable length of single-mode fiber (SMF). The fabricated CuO-SA has 3.5% modulation depth and 3.3 MW/cm2 saturation intensity. The mode-locked train pulses have 1.7 ps pulse width and 983 kHz repetition rate, while the pulse energy and output power are 1.29 nJ and 1.27 mW, respectively, at maximum pump power of 159 mW. These results indicate that the CuO thin film is a good SA candidate for a fiber laser operating at a low pump power. To the best of our knowledge, this is the first demonstration of a CuO-SA-based mode-locked fiber laser.

Reversible thermo-pneumatic valves on centrifugal microfluidic platforms.

Centrifugal microfluidic systems utilize a conventional spindle motor to automate parallel biochemical assays on a single microfluidic disk. The integration of complex, sequential microfluidic procedures on these platforms relies on robust valving techniques that allow for the precise control and manipulation of fluid flow. The ability of valves to consistently return to their former conditions after each actuation plays a significant role in the real-time manipulation of fluidic operations. In this paper, we introduce an active valving technique that operates based on the deflection of a latex film with the potential for real-time flow manipulation in a wide range of operational spinning speeds. The reversible thermo-pneumatic valve (RTPV) seals or reopens an inlet when a trapped air volume is heated or cooled, respectively. The RTPV is a gas-impermeable valve composed of an air chamber enclosed by a latex membrane and a specially designed liquid transition chamber that enables the efficient usage of the applied thermal energy. Inputting thermo-pneumatic (TP) energy into the air chamber deflects the membrane into the liquid transition chamber against an inlet, sealing it and thus preventing fluid flow. From this point, a centrifugal pressure higher than the induced TP pressure in the air chamber reopens the fluid pathway. The behaviour of this newly introduced reversible valving system on a microfluidic disk is studied experimentally and theoretically over a range of rotational frequencies from 700 RPM to 2500 RPM. Furthermore, adding a physical component (e.g., a hemispherical rubber element) to induce initial flow resistance shifts the operational range of rotational frequencies of the RTPV to more than 6000 RPM. An analytical solution for the cooling of a heated RTPV on a spinning disk is also presented, which highlights the need for the future development of time-programmable RTPVs. Moreover, the reversibility and gas impermeability of the RTPV in the microfluidic networks are validated on a microfluidic disk designed for performing liquid circulation. Finally, an array of RTPVs is integrated into a microfluidic cartridge to enable sequential aliquoting for the conversion of dengue virus RNA to cDNA and the preparation of PCR reaction mixtures.

Biosensing enhancement of dengue virus using microballoon mixers on centrifugal microfluidic platforms.

Dengue is the current leading cause of death among children in several Latin American and Asian countries. Due to poverty in areas where the disease is prevalent and the high cost of conventional diagnostic systems, low cost devices are needed to reduce the burden caused by dengue infection. Centrifugal microfluidic platforms are an alternative solution to reduce costs and increase the availability of a rapid diagnostic system. The rate of chemical reactions in such devices often depends on the efficiency of the mixing techniques employed in their microfluidic networks. This paper introduces a micromixer that operates by the expansion and contraction of a microballoon to produce a consistent periodical 3D reciprocating flow. We established that microballoons reduced mixing time of 12 µl liquids from 170 min, for diffusional mixing, to less than 23 s. We have also tested the effect of the microballoon mixers on the detection of the dengue virus. The results indicate that employing a microballoon mixer enhances the detection sensitivity of the dengue virus by nearly one order of magnitude compared to the conventional ELISA method.

All-fiber dual wavelength passive Q-switched fiber laser using a dispersion-decreasing taper fiber in a nonlinear loop mirror.

This paper describes a proposal and successful demonstration of a dual wavelength all-fiber passively Q-switched erbium-doped fiber ring laser. The Q-switch operation was realized by using a nonlinear loop mirror that incorporated an unbalanced dispersion-decreasing taper fiber to act as a saturable absorber without additional elements. This setup enabled a fiber ring laser to achieve a performance of 48.7 kHz repetition rate with pulse duration of around 3.2 µs and approximate pulse energy of 20 nJ.

Classification of reflected signals from cavitated tooth surfaces using an artificial intelligence technique incorporating a fiber optic displacement sensor.

An enhanced dental cavity diameter measurement mechanism using an intensity-modulated fiber optic displacement sensor (FODS) scanning and imaging system, fuzzy logic as well as a single-layer perceptron (SLP) neural network, is presented. The SLP network was employed for the classification of the reflected signals, which were obtained from the surfaces of teeth samples and captured using FODS. Two features were used for the classification of the reflected signals with one of them being the output of a fuzzy logic. The test results showed that the combined fuzzy logic and SLP network methodology contributed to a 100% classification accuracy of the network. The high-classification accuracy significantly demonstrates the suitability of the proposed features and classification using SLP networks for classifying the reflected signals from teeth surfaces, enabling the sensor to accurately measure small diameters of tooth cavity of up to 0.6 mm. The method remains simple enough to allow its easy integration in existing dental restoration support systems.

Gain-shift induced by dopant concentration ratio in a Thulium-Bismuth doped fiber amplifier.

This paper details the effect of Thulium and Bismuth concentration ratio on gain-shift at 1800 nm and 1400 nm band in a Thulium-Bismuth Doped Fiber Amplifier (TBDFA). The effect of Thulium and Bismuth's concentration ratio on gain shifting is experimentally established and subsequently numerically modeled. The analysis is carried out via the cross relaxation and energy transfer processes between the two dopants. The energy transfer in this process was studied through experimental and numerical analysis of three samples with different Tm/Bi concentration ratio of 2, 0.5 and 0.2, respectively. The optimized length for the three samples (TBDFA-1, TBDFA-2 and TBDFA-3) was determined and set at 6.5, 4 and 5.5 m, respectively. In addition, the experimental result of Thulium Doped Fiber Amplifier (TDFA) was compared with the earlier TBDFA samples. The gain for TBDFA-1, with the highest Tm/Bi ratio, showed no shift at the 1800 nm region, while TBDFA-2 and TBDFA-3, possessing a lower Tm/Bi concentration ratio, shifted to the region of 1950 and 1960 nm, respectively. The gain shifting from 1460 nm to 1490 nm is also observed. The numerical model demonstrates that the common 3F4 layer for 1460 nm emission (3H4→3F4), and 1800 nm emission (3F4→3H6)inversely affects the 1460 nm and 1800 nm gain shifting.

Latex micro-balloon pumping in centrifugal microfluidic platforms.

Centrifugal microfluidic platforms have emerged as point-of-care diagnostic tools. However, the unidirectional nature of the centrifugal force limits the available space for multi-step processes on a single microfluidic disc. To overcome this limitation, a passive pneumatic pumping method actuated at high rotational speeds has been previously proposed to pump liquid against the centrifugal force. In this paper, a novel micro-balloon pumping method that relies on elastic energy stored in a latex membrane is introduced. It operates at low rotational speeds and pumps a larger volume of liquid towards the centre of the disc. Two different micro-balloon pumping mechanisms have been designed to study the pump performance at a range of rotational frequencies from 0 to 1500 rpm. The behaviour of the micro-balloon pump on the centrifugal microfluidic platforms has been theoretically analysed and compared with the experimental data. The experimental data show that the developed pumping method dramatically decreases the required rotational speed to pump liquid compared to the previously developed pneumatic pumping methods. It also shows that within a range of rotational speed, a desirable volume of liquid can be stored and pumped by adjusting the size of the micro-balloon.