Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 17 de 17
Filter
Add more filters










Publication year range
1.
Ultrasonics ; 131: 106956, 2023 May.
Article in English | MEDLINE | ID: mdl-36827908

ABSTRACT

A unified model based on the ultrasonic lag phase slope is developed for measuring the lubricating film thickness at a large scale. The ultrasonic lag phase of adjacent waves instead of the phase of overlapped waves is calculated as a function of the ultrasonic frequency and film thickness. The slope of the ultrasonic lag phase is determined correspondingly, which is linearly proportional to the lubricating film thickness. Both the finite element analysis and tests on the lubricating film thickness are performed to verify the proposed method. The results show that despite the fluctuations of the lag phase, the lag phase slope can be used for measuring the lubricating film thickness at a large scale from 0.1 µm to 170 µm.

2.
Ying Yong Sheng Tai Xue Bao ; 32(12): 4203-4211, 2021 Dec.
Article in Chinese | MEDLINE | ID: mdl-34951261

ABSTRACT

Soil moisture is an important hydrological parameter and a basic element for research in water cycle and climate change. Using hourly recorded soil moisture data of 374 stations from the new generation of automatic soil moisture encryption observation network constructed by China Meteo-rological Administration, we analyzed the spatial and temporal variations of soil moisture in North China from 2013 to 2019 and the relationship with precipitation and temperature. The results showed that soil moisture in 10-100 cm layer decreased fluctuatly as a whole, with the decreasing at the 100 cm being serious. The spatial distribution of soil moisture at different depths was characterized by high in the southeast and low in the northwest. About 63% of the surface layer was short of moisture. Soil moisture at different depths changed significantly with the seasons. In summer, soil moisture of each layer reached the highest and soil entropy of each layer was suitable, while it reached a low point in spring. Soil moisture was closely correlated with precipitation and temperature, but the correlation got weaker gradually with the increase of soil depth. Soil moisture was more sensitive to precipitation than to temperature.


Subject(s)
Soil , Water , China , Seasons , Temperature , Water/analysis
3.
Ann Clin Transl Neurol ; 8(10): 1951-1960, 2021 10.
Article in English | MEDLINE | ID: mdl-34453779

ABSTRACT

BACKGROUND: Intracerebral hemorrhage (ICH) causes neurotransmitter release, oligemia, membrane depolarization, mitochondrial dysfunction, and results in the high rate of mortality and functional disability. Here, we focus on PTEN-induced kinase 1 (PINK1), a mitochondrial-targeted protein kinase, and explore its role in ICH progression. METHODS: The qPCR and Western blot were performed to examine the expression of PINK1 in ICH patients and mouse model. PINK1 gain- and loss-of-function mice were used to evaluate their protective role on brain injury and behavioral disorders. Flow cytometry was carried out, mitochondrial membrane potential and reactive oxygen species production were detected to explore the distribution and neuroprotective function of PINK1. RESULTS: PINK1 mRNA was upregulated, however, its protein was downregulated in ICH patients. The reduction of PINK1 was mainly happened in microglial cells in ICH model. Overexpression of PINK1 is able to rescue ICH-induced behavioral disorders. PINK1 protects ICH-induced brain injury by promoting mitochondrial autophagy in microglia. CONCLUSION: PINK1 possesses a neuroprotective role and antagonizes ICH by promoting mitochondrial autophagy, which may be of value as a therapeutic target for ICH treatment.


Subject(s)
Autophagy/physiology , Cerebral Hemorrhage/metabolism , Microglia/metabolism , Mitochondria/metabolism , Protein Kinases/metabolism , Animals , Disease Models, Animal , Humans , Male , Mice , Mice, Inbred C57BL , Mice, Knockout
4.
Neurol Res ; 43(6): 503-510, 2021 Jun.
Article in English | MEDLINE | ID: mdl-33402058

ABSTRACT

Background: To determine the correlation of inflammatory and platelet volume indices with the severity of stroke and 3-month clinical outcomes in patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT).Methods: A retrospective analysis was conducted for AIS patients who underwent EVT at our hospital from 2015 to 2019. Inflammatory factors, including white blood count, neutrophil count, lymphocyte count, neutrophil to lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hs-CRP), procalcitonin (PCT) and interleukin-6 (IL-6), and platelet volume indices, including platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and MPV/PC levels were assessed. Results were analyzed between patients with favorable and unfavorable outcomes at 3 months post-EVT.Results: A total of 257 AIS patients were included in the study. There were 86 (33.5%) patients with favorable functional outcomes at 3 months. Compared to patients with favorable outcomes, those with poor outcomes have lower lymphocyte count, higher neutrophil count and NLR levels. There were no differences in hs-CRP,PCT and IL-6 between the two groups. The correlation analysis showed that the increase in MPV, PDW, and MPV/PC was related to the high level of the NIHSS score at admission. Multivariate logistic regression analysis showed that higher NLR levels are an independent risk factor for unfavorable outcomes at 3 months (OR = 1.141; 95% CI 1.061 to 1.227, P = 0.000).Conclusions: MPV, PDW, and MPV/PC are associated with stroke severity. Higher NLR levels upon admission may predict unfavorable functional outcomes in patients with AIS after undergoing EVT.Abbreviations ACA: anterior cerebral artery; AIS: acute ischemic stroke; ASPECTS: alberta stroke program early CT score; BMI: body mass index; DBP: diastolic blood pressure; END: early neurological deterioration; EVT: endovascular thrombectomy; hs-CRP: high-sensitivity C-reactive protein; HT: hemorrhagic transformation; ICA: internal carotid artery; IL-6: interleukin-6; IS: ischemic progression; LAA: Large-Artery Atherosclerosis; MCA: middle cerebral artery; MPV: mean platelet volume; mTICI: modified thrombolysis in cerebral infarction; NIHSS: National Institute of Health stroke scale; NLR: neutrophil to lymphocyte ratio; OTP: onset-to-puncture; PC: platelet count; PCT: procalcitonin; PDW: platelet distribution width; SBP: systolic blood pressure; sICH: symptomatic intracerebral hemorrhageWBC: white blood cell.


Subject(s)
Endovascular Procedures/methods , Inflammation/blood , Ischemic Stroke/blood , Mean Platelet Volume , Thrombectomy/methods , Aged , Biomarkers/blood , Female , Humans , Ischemic Stroke/surgery , Leukocyte Count , Male , Middle Aged , Platelet Count , Prognosis , Treatment Outcome
5.
Metab Brain Dis ; 35(7): 1157-1164, 2020 10.
Article in English | MEDLINE | ID: mdl-32643094

ABSTRACT

To determine the correlation of uric acid (UA) with hemorrhagic transformation (HT) and poor short-term functional outcomes in anterior circulation acute ischemic stroke (AIS) patients after endovascular thrombectomy (EVT). A retrospective analysis was conducted for anterior circulation AIS patients who underwent EVT at our hospital from 2015 to 2019. HT within 72 h was documented according to the European Cooperative Acute Stroke Study II Classification. Baseline demographic, clinical and laboratory data were compared between the HT and non-HT groups, and between patients with favorable and unfavorable outcomes on 90-day. A total of 247 AIS patients were enrolled, of which 92 (37.2%) and 85 (34.4%) experienced HT and had favorable functional outcomes at 3 months respectively. Patients with HT had significantly lower UA levels compared to those without HT (322.60 ± 94.49 vs. 350.25 ± 99.28 µmol /L, P = 0.032). In contrast, UA levels were similar in patients with good or poor outcomes (345.67 ± 103.55 vs. 336.95 ± 95.5 µmol /L, P = 0.509). Compared to the patients with UA levels in the first quartile, those in the fourth quartile were at a higher risk of HT in univariate logistic regression analysis (OR = 0.383, 95% CI = 0.173-0.848, P = 0.018). The association remained significant after multivariable adjustment for potential confounders. A lower UA level is an independent risk factor of HT post-EVT in anterior circulation AIS patients, but is not associated with the short-term functional outcomes.


Subject(s)
Intracranial Hemorrhages/blood , Ischemic Stroke/blood , Thrombectomy/adverse effects , Uric Acid/blood , Adolescent , Adult , Aged , Aged, 80 and over , Biomarkers/blood , Female , Humans , Intracranial Hemorrhages/etiology , Ischemic Stroke/complications , Male , Middle Aged , Prognosis , Retrospective Studies , Young Adult
6.
Chin Med J (Engl) ; 133(14): 1655-1661, 2020 Jul 20.
Article in English | MEDLINE | ID: mdl-32604178

ABSTRACT

BACKGROUND: Early neurologic deterioration (END) may occur in patients with anterior circulation ischemic stroke (ACIS) after receiving endovascular treatment (EVT). Hemodynamic insufficiency, re-occlusion, and post-re-canalization hyper-perfusion are likely to play a critical role in END. We hypothesized that hemodynamic changes can predict END in patients with ACIS post-successful EVT using trans-cranial Doppler (TCD). METHODS: We utilized a prospectively maintained database of ACIS patients treated with EVT between September 2016 and June 2018 in the Xuanwu Hospital, Capital Medical University. TCD parameters including peak systolic velocity (PSV), bilateral mean flow velocity (MFV), and pulse index (PI) were determined via the middle cerebral arteries within 72 h post-EVT. A logistic regression model was applied to detect independent predictors for END. RESULTS: Totally, 112 EVT patients were included in this study and 80/112 patients experienced successful re-canalization with <50% residual stenosis, while 17/80 (21.3%) patients suffered END, for which vasogenic cerebral edema (11/17) was considered as a leading role and followed by symptomatic intra-cranial hemorrhage (4/17) and ischemia progression (2/17). For the 80 patients, the PSV (median: 127 cm/s vs. 116 cm/s, P = 0.039), the ratio of ipsilateral-MFV/contra-lateral-MFV (iMFV/cMFV) (median: 1.29 vs. 1.02, P = 0.036) and iMFV/mean blood pressure (MBP) (median: 0.97 vs. 0.79, P = 0.008) in END patients were higher than those of non-END. Using the receiver-operating characteristic curve to obtain cut-off values for PSV, PI, iMFV/cMFV, and iMFV/MBP for END, we found that PI ≥0.85 (odds ratio: 11.03, 95% confidence interval: 1.92-63.46, P = 0.007) and iMFV/MBP ≥0.84 (odds ratio: 9.20, 95% confidence interval: 2.07-40.84, P = 0.004) were independent predictors of END in a multivariate logistic regression model, with a sensitivity of 82.4% and 76.5% and a specificity of 42.9% and 66.7%, respectively, and had the positive predictive values of 29.0% and 38.2%, and negative predictive values of 90.0% and 91.3%, with an area under the receiver-operating characteristic curve of 0.57 and 0.71, respectively. CONCLUSION: TCD examination of EVT patients may be used as a real-time tool to detect END predictors, such as the higher PI and iMFV/MBP, allowing for better post-thrombectomy management in ACIS patients.


Subject(s)
Brain Ischemia , Endovascular Procedures , Ischemic Stroke , Stroke , Brain Ischemia/diagnostic imaging , Humans , Skull , Stroke/diagnostic imaging , Thrombectomy
7.
Cerebrovasc Dis ; 49(2): 160-169, 2020.
Article in English | MEDLINE | ID: mdl-32316014

ABSTRACT

OBJECTIVE: This study aimed to control blood pressure (BP) under transcranial Doppler (TCD) guidance in patients with anterior circulation acute ischemic stroke after endovascular treatment (EVT) to reduce the incidence of early neurological deterioration (END) and improve neurological prognosis. METHODS: This prospective randomized controlled study included 95 patients who were randomly divided into a TCD-guided BP control (TBC) group and a non-TCD-guided BP control (NBC) group. The patients were monitored by TCD within 72 h after EVT. In the TBC group, BP decreased, BP increased, or intracranial pressure decreased when TCD showed blood flow acceleration, deceleration, or intracranial hypertension respectively. The BP of the NBC group was controlled according to the guidelines. The incidence of END and the prognosis was compared between the 2 groups. RESULTS: TCD identified 18 patients with blood flow acceleration, but the prognosis of the 2 groups was not significantly different. TCD identified 23 patients with blood flow deceleration, and the poor prognosis rate at discharge was lower in the TBC group than in the NBC group (45.5 vs. 91.7%, p = 0.027). TCD identified 34 patients with intracranial hypertension, and the 3-month mortality rate of the TBC group was lower than that of the NBC group (0 vs. 36.8%, p = 0.011). The incidence rates of END and 3-month mortality in the TBC group were lower than those in the NBC group (13.8 vs. 37.5%, p = 0.036; 0 vs. 25.0%, p = 0.012) when TCD parameters were abnormal. Multivariable logistic regression analysis showed that the TBC group (adjusted OR 0.267, 95% CI 0.074-0.955; p = 0.042) was an independent protective factor against the incidence of END when TCD parameters were abnormal. CONCLUSION: These findings indicated that TCD-guided BP and intracranial pressure control improved the prognosis of patients with blood flow deceleration and intracranial hypertension.


Subject(s)
Blood Pressure , Brain Ischemia/therapy , Endovascular Procedures/adverse effects , Intracranial Hypertension/diagnostic imaging , Intracranial Pressure , Stroke/therapy , Ultrasonography, Doppler, Transcranial , Aged , Beijing , Blood Flow Velocity , Brain Ischemia/diagnostic imaging , Brain Ischemia/mortality , Brain Ischemia/physiopathology , Endovascular Procedures/mortality , Female , Humans , Intracranial Hypertension/etiology , Intracranial Hypertension/mortality , Intracranial Hypertension/physiopathology , Male , Middle Aged , Predictive Value of Tests , Prospective Studies , Stroke/diagnostic imaging , Stroke/mortality , Stroke/physiopathology , Time Factors , Treatment Outcome
8.
Neurol Sci ; 41(7): 1821-1828, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32056057

ABSTRACT

OBJECTIVE: To determine the correlation of thyroid hormone status with hemorrhagic transformation (HT) and short-term clinical outcomes in patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT) METHODS: A retrospective analysis was conducted on AIS patients who underwent EVT at our hospital from 2016 to 2019. Thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), free triiodothyronine (FT3), total thyroxine (TT4), and free thyroxine (FT4) levels were assessed, and logistic regression analyses were performed with HT incidence and functional outcome at 3 months. RESULTS: A total of 199 patients (148 males; mean age 62.9 ± 13.1 years) were included in the study. The number of patients with HT and unfavorable functional outcomes at 3 months were 74 (37.2%) and 129 (64.8%), respectively. Multiple logistic regression analysis showed that low TSH level (OR = 0.609; 95% CI 0.402-0.920, 푃 = 0.019) was an independent risk factor of poor functional outcome, while none of the thyroid hormones were significantly associated with HT risk. The optimal cutoff value of TSH that best distinguished both unfavorable outcome (sensitivity 31%, specificity 88.6%, area under the curve (AUC) 0.586) and mortality at 3 months (sensitivity 47.4%, specificity 78.3%, AUC 0.606) was 0.485 uIU/ml. CONCLUSION: A lower TSH value upon admission may predict an unfavorable functional outcome in AIS patients after EVT, but thyroid hormone levels have no bearing on the risk of HT.


Subject(s)
Brain Ischemia , Ischemic Stroke , Thrombectomy , Thyrotropin/blood , Aged , Brain Ischemia/complications , Female , Humans , Male , Middle Aged , Retrospective Studies , Thyroxine , Treatment Outcome , Triiodothyronine
9.
Microsyst Nanoeng ; 6: 8, 2020.
Article in English | MEDLINE | ID: mdl-34567623

ABSTRACT

This paper introduces the first tunable ferroelectric capacitor (FeCAP)-based unreleased RF MEMS resonator, integrated seamlessly in Texas Instruments' 130 nm Ferroelectric RAM (FeRAM) technology. The designs presented here are monolithically integrated in solid-state CMOS technology, with no post-processing or release step typical of other MEMS devices. An array of FeCAPs in this complementary metal-oxide-semiconductor (CMOS) technology's back-end-of-line (BEOL) process were used to define the acoustic resonance cavity as well as the electromechanical transducers. To achieve high quality factor (Q) of the resonator, acoustic waveguiding for vertical confinement within the CMOS stack is studied and optimized. Additional design considerations are discussed to obtain lateral confinement and suppression of spurious modes. An FeCAP resonator is demonstrated with fundamental resonance at 703 MHz and Q of 1012. This gives a frequency-quality factor product f ⋅ Q = 7.11 × 1 0 11 which is 1.6× higher than the most state-of-the-art Pb(Zr,Ti)O3 (PZT) resonators. Due to the ferroelectric characteristics of the FeCAPs, transduction of the resonator can be switched on and off by adjusting the electric polarization. In this case, the resonance can be turned off completely at ±0.3 V corresponding to the coercive voltage of the constituent FeCAP transducers. These novel switchable resonators may have promising applications in on-chip timing, ad-hoc radio front ends, and chip-scale sensors.

10.
J Stroke Cerebrovasc Dis ; 29(1): 104494, 2020 Jan.
Article in English | MEDLINE | ID: mdl-31727596

ABSTRACT

OBJECTIVE: To investigate whether contrast extravasation on dual-energy computed tomography (DECT) in patients with acute ischemic stroke (AIS) after endovascular therapy (EVT) are related to hemorrhagic transformation (HT) and poor short-term clinical outcomes. METHODS: A retrospective analysis was conducted on AIS patients who underwent EVT at Xuanwu hospital between November 2016 and January 2019. DECT was performed on all patients within 24 hours after EVT. Baseline demographic and clinical data were analyzed between patients with and without contrast extravasation and between patients with HT and non-HT, good and poor outcomes at 3 months post-EVT. RESULTS: A total of 166 patients were included in the study with 51 (30.7%) patients experiencing contrast extravasation. Compared to patients without contrast extravasation, patients with contrast extravasation had longer onset to reperfusion time (444.8 minutes versus 374.0 minutes, P = .044) and higher percentages of greater than 3 retriever passes (16.7% versus 31.4%, P = .030). Contrast extravasation was associated with higher risk of HT (P = .038), poor outcome after discharge (P = .030), and longer hospital stay (P = .034). Multivariate analysis showed that contrast extravasation occurrence was an independent factor for HT (OR = 2.150, 95% CI 1.060-4.360, P = .034) and poor short-term outcome (OR = 2.936; 95% CI 1.147-7.518, P = .025). CONCLUSIONS: The presence of contrast extravasation within 24 hours of EVT may be associated with higher risks of HT and may be predictive of unfavorable functional outcomes in AIS patients.


Subject(s)
Brain Ischemia/therapy , Contrast Media/administration & dosage , Endovascular Procedures/adverse effects , Extravasation of Diagnostic and Therapeutic Materials , Intracranial Hemorrhages/diagnostic imaging , Multidetector Computed Tomography , Stroke/therapy , Thrombectomy/adverse effects , Thrombolytic Therapy/adverse effects , Adult , Aged , Aged, 80 and over , Beijing , Brain Ischemia/diagnostic imaging , Female , Humans , Intracranial Hemorrhages/etiology , Male , Middle Aged , Predictive Value of Tests , Retrospective Studies , Risk Assessment , Risk Factors , Stroke/diagnostic imaging , Time Factors , Treatment Outcome
11.
World Neurosurg ; 130: e583-e587, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31254696

ABSTRACT

OBJECTIVE: Endovascular treatment (EVT) is a promising clinical technology. However, some patients with posterior circulation stroke might not experience neurological function recovery after EVT. We reviewed the recent experience with EVT to clarify the clinical and radiographic factors that contribute to optimal neurological outcomes. METHODS: We analyzed the data from 108 consecutive patients with acute posterior circulation stroke who had undergone EVT from January 2016 to December 2018. A favorable outcome was defined as a modified Rankin scale score of 0-3 at 3 months. We evaluated the association and predictive value of the clinical and radiographic factors that contribute to good neurological outcomes. RESULTS: Of the 108 included patients, 43 had a favorable clinical outcome at day 90. Univariate analysis revealed a significant association between the 90-day favorable outcome and the baseline values of systolic blood pressure, time of stroke onset, contrast extravasation, symptomatic intracranial hemorrhage, general anesthesia, Alberta stroke program early computed tomography score for the posterior circulation, and the National Institutes of Health stroke scale (NIHSS) score. Contrast extravasation (odds ratio [OR], 5.094; 95% confidence interval [CI], 1.22-21.261), symptomatic intracranial hemorrhage (OR, 11.24; 95% CI, 1.309-96.517), general anesthesia (OR, 5.094; 95% CI, 1.22-21.26), and baseline NIHSS score (OR, 1.087; 95% CI, 1.023-1.309) were found to be independent predictors of a favorable outcome at day 90. Contrast extravasation alone predicted for unfavorable clinical outcomes and mortality with high specificity. CONCLUSION: In the present retrospective case series, contrast extravasation, symptomatic intracranial hemorrhage, the use of general anesthesia, and baseline NIHSS score were related to a favorable prognosis for patients with posterior circulation stroke after EVT. Contrast extravasation was an independent and strong predictor of unfavorable clinical outcomes.


Subject(s)
Brain Ischemia/therapy , Endovascular Procedures/adverse effects , Extravasation of Diagnostic and Therapeutic Materials/etiology , Intracranial Hemorrhages/therapy , Stroke/therapy , Aged , Female , Humans , Male , Middle Aged , Prognosis , Retrospective Studies , Treatment Outcome
12.
Brain Circ ; 4(2): 65-72, 2018.
Article in English | MEDLINE | ID: mdl-30276339

ABSTRACT

Ischemic stroke as an initial presentation of malignancy is extremely rare and the underlying etiology is often ignored. The aim of this study is to outline the clues to occult malignancy in patients presenting with cerebral infarction initially. The clinical characteristics of total 19 patients with Trousseau's Syndrome presenting with cerebral infarction initially were analyzed. Among those patients, no conventional vascular risk factors were detected in 68% (13/19) of patients, and infarction occurring in multiple vascular distributions was found in 84% (16/19). Blood test showed thrombophilia in 79% (15/19) of patients with significantly elevated D-dimer, disseminated intravascular coagulopathy (DIC) in 59% (11/19), and elevated levels of tumor makers in 47% (9/19). The prognosis of the 19 patients was poor, with 68% (13/19) of patients undergoing a relapse of stroke in short interval, and 84% (16/19) being reportedly to die in 6 months. In patients, who developed unexplained recurrent brain infarction involving multiple arterial territory, with laboratory evidence suggesting hypercoagulability (higher level of D-dimer, or DIC), Trousseau's Syndrome should be considered, and investigation for an occult malignancy was required.

13.
Neurocrit Care ; 29(2): 264-272, 2018 10.
Article in English | MEDLINE | ID: mdl-29651625

ABSTRACT

BACKGROUND AND PURPOSE: Data concerning the characteristics and duration of the critical manifestations, treatment response, and long-term outcomes of severe anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis patients compared to those of non-severe patients are limited. This observational study was performed to explore the clinical characteristics and long-term outcomes of severe anti-NMDAR encephalitis patients. METHODS: According to their characteristics on admission to the neurology intensive care unit, patients with anti-NMDAR encephalitis were divided into a severe group and a non-severe group. The demographics, clinical manifestations, main accessory examinations, immunotherapy, and outcomes of patients were recorded. Statistical analyses were employed to examine the differences in each observed indicator between the severe and non-severe groups. RESULTS: This study enrolled 111 patients with anti-NMDAR encephalitis, including 59 males and 52 females with a mean age of 27.7 ± 13.7 years; 39 (35.1%) patients were in the severe group, and 72 (64.9%) patients were in the non-severe group. Compared to the non-severe group, the severe group exhibited a higher proportion of epilepsy, involuntary movement, disturbance of consciousness, autonomic dysfunction, and central hypoventilation. The cerebrospinal fluid (CSF) of all patients was positive for the NMDAR antibody, but only 57 patients (51.4%) tested positive for the NMDAR antibody in the blood. The proportion of patients with a strong positive NMDAR antibody titer in the severe group (48.7%) was higher than that in the non-severe group (29.2%). The proportion of patients receiving intravenous gamma immunoglobulin in the severe group was higher than that in the non-severe group (P = 0.003), and only patients in the severe group received plasma exchange, intravenous rituximab, and cyclophosphamide treatment. No significant difference was observed in the prognosis between the severe group and the non-severe group after 6 months and during long-term follow-up. CONCLUSION: Most severe anti-NMDAR encephalitis patients will eventually achieve good long-term prognoses after receiving early, positive and unremitting combined immunotherapy and life support.


Subject(s)
Anti-N-Methyl-D-Aspartate Receptor Encephalitis , Outcome Assessment, Health Care , Severity of Illness Index , Adolescent , Adult , Aged , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/immunology , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/physiopathology , Anti-N-Methyl-D-Aspartate Receptor Encephalitis/therapy , Critical Care , Female , Follow-Up Studies , Humans , Intensive Care Units , Male , Middle Aged , Prognosis , Young Adult
14.
Chin Med J (Engl) ; 131(2): 137-143, 2018 Jan 20.
Article in English | MEDLINE | ID: mdl-29336360

ABSTRACT

BACKGROUND: Early neurological deterioration (END) is a prominent issue after recanalization treatment. However, few studies have reported the characteristics of END after endovascular treatment (EVT) as so far. This study investigated the incidence, composition, and outcomes of END after intravenous recombinant tissue plasminogen activator (IV rt-PA) and EVT of acute ischemic stroke, and identified risk factors for END. METHODS: Medical records of patients who received recanalization treatment between January 1, 2014, and December 31, 2015 were reviewed. Patients were classified into IV rt-PA or EVT group according to the methods of recanalization treatment. The END was defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) ≥4 or an increase in Ia of NIHSS ≥1 within 72 h after recanalization treatment. Clinical data were compared between the END and non-END subgroups within each recanalization group. RESULTS: Of the 278 patients included in the study, the incidence of END was 34.2%. The incidence rates of END were 29.8% in the IV rt-PA group and 40.2% in the EVT group. Ischemia progression (68.4%) was the main contributor to END followed by vasogenic cerebral edema (21.1%) and symptomatic intracranial hemorrhage (10.5%). Multivariate logistic regression showed that admission systolic blood pressure (SBP) ≥160 mmHg (odds ratio [OR]: 2.312, 95% confidence interval [CI]: 1.105-4.837) and large artery occlusion after IV rt-PA (OR: 3.628, 95% CI: 1.482-8.881) independently predicted END after IV rt-PA; and admission SBP ≥140 mmHg (OR: 5.183, 95% CI: 1.967-13.661), partial recanalization (OR: 4.791, 95% CI: 1.749-13.121), and nonrecanalization (OR: 5.952, 95% CI: 1.841-19.243) independently predicted END after EVT. The mortality rate and grave outcome rate at discharge of all the END patients (26.3% and 55.8%) were higher than those of all the non-END patients (1.1% and 18.6%; P < 0.01). CONCLUSIONS: END was not an uncommon event and associated with death and grave outcome at discharge. High admission SBP and unsatisfactory recanalization of occluded arteries might predict END.


Subject(s)
Brain Diseases/etiology , Brain Ischemia/drug therapy , Stroke/drug therapy , Thrombolytic Therapy/methods , Tissue Plasminogen Activator/adverse effects , Adult , Aged , Female , Humans , Logistic Models , Male , Middle Aged , Retrospective Studies
15.
Ying Yong Sheng Tai Xue Bao ; 20(10): 2384-90, 2009 Oct.
Article in Chinese | MEDLINE | ID: mdl-20077694

ABSTRACT

Based on the time series 10-day composite NOAA Pathfinder AVHRR Land (PAL) dataset (8 km x 8 km), and by using land surface energy balance equation and "VI-Ts" (vegetation index-land surface temperature) method, a new algorithm of land surface evapotranspiration (ET) was constructed. This new algorithm did not need the support from meteorological observation data, and all of its parameters and variables were directly inversed or derived from remote sensing data. A widely accepted ET model of remote sensing, i. e., SEBS model, was chosen to validate the new algorithm. The validation test showed that both the ET and its seasonal variation trend estimated by SEBS model and our new algorithm accorded well, suggesting that the ET estimated from the new algorithm was reliable, being able to reflect the actual land surface ET. The new ET algorithm of remote sensing was practical and operational, which offered a new approach to study the spatiotemporal variation of ET in continental scale and global scale based on the long-term time series satellite remote sensing images.


Subject(s)
Satellite Communications , Soil/analysis , Water Movements , Water/analysis , Algorithms , Data Interpretation, Statistical , Models, Theoretical , Volatilization
16.
Ying Yong Sheng Tai Xue Bao ; 18(2): 288-96, 2007 Feb.
Article in Chinese | MEDLINE | ID: mdl-17450729

ABSTRACT

In this paper, surface energy balance system (SEBS) was extended into a regional daily evapotranspiration (ET) estimation model based on remote sensing data, and the extended SEBS was applied to estimate the regional daily ET of Huanghe-Huaihe-Haihe rivers region in Northern China Plain by using MODIS/TERRA data. An analysis was made on the estimated daily ET characteristics of different land covers in the study area by using the spatial analysis module of ArcGIS. Since there were no field observations of ET on each land cover, the estimated daily ET of different land covers was compared with each other, taking the data on April 17, 2001 as an example. The results showed that the regional daily ET estimated by SEBS was reasonable. Wetland and cultivated land had the highest daily ET value, followed by forest-, bush- and grassland, and waste land. The characteristics of the daily ET over these land covers were accorded with the existing knowledge of ET over this region, and coincident to the results of previous work in this area. It was interesting that the residential area also had a higher ET value, which was explained as the higher ET of the land use types, e. g. , water body, street trees, and grass parcels in the resident areas within the pixel scale. The spatial inhomogeneity of ET among the forest-, bush-, grass- and cultivated land covers were caused by the spatial inhomogeneous soil water content under these land covers, and the spatial inhomogeneity of ET over cultivated land could be a potential indicator of making reasonable and effective irrigation schedule for the farmland. The limitations of using SEBS model in daily ET estimation were discussed, especially the possibility of underestimating the ET over water body and wetland covers due to the unsuitable surface parameterization scheme for these land types in the model.


Subject(s)
Ecosystem , Soil/analysis , Water Movements , Water/analysis , Environmental Monitoring , Geographic Information Systems , Models, Theoretical , Plant Transpiration , Satellite Communications
17.
Ying Yong Sheng Tai Xue Bao ; 15(2): 210-4, 2004 Feb.
Article in Chinese | MEDLINE | ID: mdl-15146625

ABSTRACT

Based on the principle of energy balance, the method for calculating latent evaporation was simplified, and hence, the construction of the drought remote sensing monitoring model of crop water shortage index was also simplified. Since the modified model involved fewer parameters and reduced computing times, it was more suitable for the operation running in the routine services. After collecting the concerned meteorological elements and the NOAA/AVHRR image data, the new model was applied to monitor the spring drought in Guanzhong, Shanxi Province. The results showed that the monitoring results from the new model, which also took more considerations of the effects of the ground coverage conditions and meteorological elements such as wind speed and the water pressure, were much better than the results from the model of vegetation water supply index. From the view of the computing times, service effects and monitoring results, the simplified crop water shortage index model was more suitable for practical use. In addition, the reasons of the abnormal results of CWSI > 1 in some regions in the case studies were also discussed in this paper.


Subject(s)
Crops, Agricultural , Disasters , Water/analysis , Satellite Communications , Volatilization
SELECTION OF CITATIONS
SEARCH DETAIL