ABSTRACT
The brain can be modelled as a network with nodes and edges derived from a range of imaging modalities: the nodes correspond to spatially distinct regions and the edges to the interactions between them. Whole-brain connectivity studies typically seek to determine how network properties change with a given categorical phenotype such as age-group, disease condition or mental state. To do so reliably, it is necessary to determine the features of the connectivity structure that are common across a group of brain scans. Given the complex interdependencies inherent in network data, this is not a straightforward task. Some studies construct a group-representative network (GRN), ignoring individual differences, while other studies analyse networks for each individual independently, ignoring information that is shared across individuals. We propose a Bayesian framework based on exponential random graph models (ERGM) extended to multiple networks to characterise the distribution of an entire population of networks. Using resting-state fMRI data from the Cam-CAN project, a study on healthy ageing, we demonstrate how our method can be used to characterise and compare the brain's functional connectivity structure across a group of young individuals and a group of old individuals.
Subject(s)
Bayes Theorem , Brain/physiology , Models, Neurological , Nerve Net/physiology , Brain Mapping/methods , Humans , Individuality , Magnetic Resonance Imaging , Models, Statistical , Neural PathwaysABSTRACT
BACKGROUND: Decades of research have investigated the impact of clinical depression on memory, which has revealed biases and in some cases impairments. However, little is understood about the effects of subclinical symptoms of depression on memory performance in the general population. METHODS: Here we report the effects of symptoms of depression on memory problems in a large population-derived cohort (N = 2544), 87% of whom reported at least one symptom of depression. Specifically, we investigate the impact of depressive symptoms on subjective memory complaints, objective memory performance on a standard neuropsychological task and, in a subsample (n = 288), objective memory in affective contexts. RESULTS: There was a dissociation between subjective and objective memory performance, with depressive symptoms showing a robust relationship with self-reports of memory complaints, even after adjusting for age, sex, general cognitive ability and symptoms of anxiety, but not with performance on the standardised measure of verbal memory. Contrary to our expectations, hippocampal volume (assessed in a subsample, n = 592) did not account for significant variance in subjective memory, objective memory or depressive symptoms. Nonetheless, depressive symptoms were related to poorer memory for pictures presented in negative contexts, even after adjusting for memory for pictures in neutral contexts. CONCLUSIONS: Thus the symptoms of depression, associated with subjective memory complaints, appear better assessed by memory performance in affective contexts, rather than standardised memory measures. We discuss the implications of these findings for understanding the impact of depressive symptoms on memory functioning in the general population.
Subject(s)
Depression/epidemiology , Memory Disorders/complications , Memory Disorders/psychology , Memory , Adolescent , Adult , Aged , Aged, 80 and over , Cognition , Cohort Studies , Female , Gray Matter/diagnostic imaging , Humans , Logistic Models , Magnetic Resonance Imaging , Male , Middle Aged , Psychiatric Status Rating Scales , Self Report , United Kingdom/epidemiology , Young AdultABSTRACT
Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalographic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.
Subject(s)
Aging , Brain/pathology , Evoked Potentials, Auditory , Gray Matter/pathology , Magnetoencephalography , Vision, Ocular , White Matter/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Atrophy , Auditory Cortex/pathology , Brain/diagnostic imaging , Brain Mapping , Cohort Studies , Electroencephalography , Female , Hearing , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Models, Neurological , Principal Component Analysis , Time Factors , Young AdultABSTRACT
Several methods have been developed to measure dynamic functional connectivity (dFC) in fMRI data. These methods are often based on a sliding-window analysis, which aims to capture how the brain's functional organization varies over the course of a scan. The aim of many studies is to compare dFC across groups, such as younger versus older people. However, spurious group differences in measured dFC may be caused by other sources of heterogeneity between people. For example, the shape of the haemodynamic response function (HRF) and levels of measurement noise have been found to vary with age. We use a generic simulation framework for fMRI data to investigate the effect of such heterogeneity on estimates of dFC. Our findings show that, despite no differences in true dFC, individual differences in measured dFC can result from other (non-dynamic) features of the data, such as differences in neural autocorrelation, HRF shape, connectivity strength and measurement noise. We also find that common dFC methods such as k-means and multilayer modularity approaches can detect spurious group differences in dynamic connectivity due to inappropriate setting of their hyperparameters. fMRI studies therefore need to consider alternative sources of heterogeneity across individuals before concluding differences in dFC.
Subject(s)
Connectome/standards , Data Interpretation, Statistical , Image Processing, Computer-Assisted/standards , Magnetic Resonance Imaging/standards , Neurovascular Coupling/physiology , Computer Simulation , Connectome/methods , Humans , Image Processing, Computer-Assisted/methods , Magnetic Resonance Imaging/methodsABSTRACT
Sternberg (2011) elegantly formalizes how certain sets of hypotheses, specifically modularity and pure or composite measures, imply certain patterns of behavioural and neuroimaging data. Experimentalists are often interested in the converse, however: whether certain patterns of data distinguish certain hypotheses, specifically whether more than one module is involved. In this case, there is a striking reversal of the relative value of the data patterns that Sternberg considers. Foremost, the example of additive effects of two factors on one composite measure becomes noninformative for this converse question. Indeed, as soon as one allows for nonlinear measurement functions and nonlinear module processes, even a cross-over interaction between two factors is noninformative in this respect. Rather, one requires more than one measure, from which certain data patterns do provide strong evidence for multiple modules, assuming only that the measurement functions are monotonic. If two measures are not monotonically related to each other across the levels of one or more experimental factors, then one has evidence for more than one module (i.e., more than one nonmonotonic transform). Two special cases of this are illustrated here: a "reversed association" between two measures across three levels of a single factor, and Sternberg's example of selective effects of two factors on two measures. Fortunately, functional neuroimaging methods normally do provide multiple measures over space (e.g., functional magnetic resonance imaging, fMRI) and/or time (e.g., electroencephalography, EEG). Thus to the extent that brain modules imply mind modules (i.e., separate processors imply separate processes), the performance data offered by functional neuroimaging are likely to be more powerful in revealing modules than are the single behavioural measures (such as accuracy or reaction time, RT) traditionally considered in psychology.
Subject(s)
Brain/physiology , Cognition/physiology , Neurons/physiology , Signal Detection, Psychological/physiology , HumansABSTRACT
Repetition priming can be caused by the rapid retrieval of previously encoded stimulus-response (S-R) bindings. S-R bindings have recently been shown to simultaneously code multiple levels of response representation, from specific Motor-actions to more abstract Decisions ("yes"/"no") and Classifications (e.g., "man-made"/"natural"). Using an experimental design that reverses responses at all of these levels, we assessed whether S-R bindings also code multiple levels of stimulus representation. Across two experiments, we found effects of response reversal on priming when switching between object pictures and object names, consistent with S-R bindings that code stimuli at an abstract level. Nonetheless, the size of this reversal effect was smaller for such across-format (e.g., word-picture) repetition than for within-format (e.g., picture-picture) repetition, suggesting additional coding of format-specific stimulus representations. We conclude that S-R bindings simultaneously represent both stimuli and responses at multiple levels of abstraction.
Subject(s)
Conditioning, Classical/physiology , Mental Recall/physiology , Repetition Priming/physiology , Adult , Female , Humans , Magnetic Resonance Imaging , Magnetoencephalography , Male , Neuropsychological Tests , Young AdultABSTRACT
We investigated four key aspects of forward models for distributed solutions to the MEG inverse problem: 1) the nature of the cortical mesh constraining sources (derived from an individual's MRI, or inverse-normalised from a template mesh); 2) the use of single-sphere, overlapping spheres, or Boundary Element Model (BEM) head-models; 3) the density of the cortical mesh (3000 vs. 7000 vertices); and 4) whether source orientations were constrained to be normal to that mesh. These were compared within the context of two types of spatial prior on the sources: a single prior corresponding to a standard L2-minimum-norm (MNM) inversion, or multiple sparse priors (MSP). The resulting generative models were compared using a free-energy approximation to the Bayesian model-evidence after fitting multiple epochs of responses to faces or scrambled faces. Statistical tests of the free-energy, across nine participants, showed clear superiority of MSP over MNM models; with the former reconstructing deeper sources. Furthermore, there was 1) no evidence that an individually-defined cortical mesh was superior to an inverse-normalised canonical mesh, but 2) clear evidence that a BEM was superior to spherical head-models, provided individually-defined inner skull and scalp meshes were used. Finally, for MSP models, there was evidence that the combination of 3) higher density cortical meshes and 4) dipoles constrained to be normal to the mesh was superior to lower-density or freely-oriented sources (in contrast to the MNM models, in which free-orientation was optimal). These results have practical implications for MEG source reconstruction, particularly in the context of group studies.
Subject(s)
Brain/physiology , Magnetoencephalography , Models, Neurological , Signal Processing, Computer-Assisted , Bayes Theorem , Humans , Magnetoencephalography/instrumentation , Magnetoencephalography/methodsABSTRACT
In this paper, we provide evidence for functional asymmetries in forward and backward connections that define hierarchical architectures in the brain. We exploit the fact that modulatory or nonlinear influences of one neuronal system on another (i.e., effective connectivity) entail coupling between different frequencies. Functional asymmetry in forward and backward connections was addressed by comparing dynamic causal models of MEG responses induced by visual processing of normal and scrambled faces. We compared models with and without nonlinear (between-frequency) coupling in both forward and backward connections. Bayesian model comparison indicated that the best model had nonlinear forward and backward connections. Using the best model we then quantified frequency-specific causal influences mediating observed spectral responses. We found a striking asymmetry between forward and backward connections; in which high (gamma) frequencies in higher cortical areas suppressed low (alpha) frequencies in lower areas. This suppression was significantly greater than the homologous coupling in the forward connections. Furthermore, exactly the asymmetry was observed when we examined face-selective coupling (i.e., coupling under faces minus scrambled faces). These results highlight the importance of nonlinear coupling among brain regions and point to a functional asymmetry between forward and backward connections in the human brain that is consistent with anatomical and physiological evidence from animal studies. This asymmetry is also consistent with functional architectures implied by theories of perceptual inference in the brain, based on hierarchical generative models.
Subject(s)
Brain Mapping/methods , Evoked Potentials, Visual/physiology , Functional Laterality/physiology , Magnetoencephalography/methods , Models, Neurological , Nerve Net/physiology , Pattern Recognition, Visual/physiology , Computer Simulation , Female , Humans , MaleABSTRACT
Prior exposure to a stimulus can facilitate its subsequent identification and classification, a phenomenon called priming. This behavioural facilitation is usually accompanied by a reduction in neural response within specific cortical regions (repetition suppression, RS). Recent research has suggested that both behavioural priming and RS can be largely determined by previously learned stimulus-response associations. According to this view, a direct association forms between the stimulus presented and the response made to it. On a subsequent encounter with the stimulus, this association automatically cues the response, bypassing the various processing stages that were required to select that response during its first presentation. Here we reproduce behavioural evidence for such stimulus-response associations, and show the PFC to be sensitive to such changes. In contrast, RS within ventral temporal regions (such as the fusiform cortex), which are usually associated with perceptual processing, is shown to be robust to response changes. The present study therefore suggests a dissociation between RS within the PFC, which may be sensitive to retrieval of stimulus-response associations, and RS within posterior perceptual regions, which may reflect facilitation of perceptual processing independent of stimulus-response associations.
Subject(s)
Association Learning/physiology , Cerebral Cortex/physiology , Practice, Psychological , Psychomotor Performance/physiology , Recognition, Psychology/physiology , Association Learning/radiation effects , Brain/physiology , Brain Mapping , Color Perception/physiology , Cues , Form Perception/physiology , Functional Laterality/physiology , Generalization, Psychological/physiology , Humans , Magnetic Resonance Imaging/statistics & numerical data , Memory/physiology , Models, Neurological , Photic Stimulation , Reaction Time/physiology , Semantics , Size Perception/physiology , Task Performance and Analysis , Temporal Lobe/physiologyABSTRACT
Using a sandwich-masked priming paradigm with faces, we report two ERP effects that appear to reflect different levels of subliminal face processing. These two ERP repetition effects dissociate in their onset, scalp topography, and sensitivity to face familiarity. The "early" effect occurred between 100 and 150 ms, was maximally negative-going over lateral temporoparietal channels, and was found for both familiar and unfamiliar faces. The "late" effect occurred between 300 and 500 ms, was maximally positive-going over centroparietal channels, and was found only for familiar faces. The early effect resembled our previous fMRI data from the same paradigm; the late effect resembled the behavioural priming found, in the form of faster reaction times to make fame judgments about primed relative to unprimed familiar faces. None of the ERP or behavioural effects appeared explicable by a measure of participants' ability to see the primes. The ERP and behavioural effects showed some sensitivity to whether the same or a different photograph of a face was repeated, but could remain reliable across different photographs, and did not appear attributable to a low-level measure of pixelwise overlap between prime and probe photograph. The functional significance of these ERP effects is discussed in relation to unconscious perception and face processing.
Subject(s)
Evoked Potentials , Face , Mental Processes , Visual Perception/physiology , Adult , Electrophysiology , Female , Humans , Male , Time FactorsABSTRACT
We address some key issues entailed by population inference about responses evoked in distributed brain systems using magnetoencephalography (MEG). In particular, we look at model selection issues at the within-subject level and feature selection issues at the between-subject level, using responses evoked by intact and scrambled faces around 170 ms (M170). We compared the face validity of subject-specific forward models and their summary statistics in terms of how estimated responses reproduced over subjects. At the within-subject level, we focused on the use of multiple constraints, or priors, for inverting distributed source models. We used restricted maximum likelihood (ReML) estimates of prior covariance components (in both sensor and source space) and show that their relative importance is conserved over subjects. At the between-subject level, we used standard anatomical normalization methods to create posterior probability maps that furnish inference about regionally specific population responses. We used these to compare different summary statistics, namely; (i) whether to test for differences between condition-specific source estimates, or whether to test the source estimate of differences between conditions, and (ii) whether to accommodate differences in source orientation by using signed or unsigned (absolute) estimates of source activity.
Subject(s)
Brain/physiology , Evoked Potentials/physiology , Face , Magnetoencephalography/methods , Analysis of Variance , Electroencephalography , Humans , Magnetic Resonance Imaging , Models, Neurological , Reference Values , Reproducibility of Results , Visual PerceptionABSTRACT
The aim of this fMRI study was to investigate whether spatial attention to the initial and/or repeated presentation of a stimulus is necessary to observe repetition-related modulations of the neural responses evoked by that stimulus. During each trial, two stimuli were presented simultaneously, one left and one right of fixation. During each block, participants were instructed to attend covertly to stimuli in one of the two hemifields and respond whether each was a face or house, ignoring the contralateral stimulus. Regions that preferred one stimulus category over the other, such as the fusiform face area and parahippocampal place area, showed evidence of some processing of the ignored stimuli. However, a reduced response to repeated stimuli (repetition suppression) was only reliable for preferred stimuli when both their initial and repeated presentations were attended. This suggests that attention is necessary for both the acquisition and expression of the neural mechanisms that underlie repetition suppression, at least over the lags of 2-16 intervening trials used here.
Subject(s)
Attention/physiology , Evoked Potentials, Visual/physiology , Learning/physiology , Pattern Recognition, Visual/physiology , Photic Stimulation/methods , Space Perception/physiology , Visual Cortex/physiology , Adult , Female , Fixation, Ocular/physiology , Humans , Magnetic Resonance Imaging/methods , Male , Visual Cortex/blood supplyABSTRACT
Prior knowledge regarding the possible identity of an object facilitates its recognition from a degraded visual input, though the underlying mechanisms are unclear. Previous work implicated ventral visual cortex but did not disambiguate whether activity-changes in these regions are causal to or merely reflect an effect of facilitated recognition. We used functional magnetic resonance imaging to study top-down influences on processing of gradually revealed objects, by preceding each object with a name that was congruent or incongruent with the object. Congruently primed objects were recognized earlier than incongruently primed, and this was paralleled by shifts in activation profiles for ventral visual, parietal, and prefrontal cortices. Prior to recognition, defined on a trial-by-trial basis, activity in ventral visual cortex rose gradually but equivalently for congruently and incongruently primed objects. In contrast, prerecognition activity was greater with congruent priming in lateral parietal, retrosplenial, and lateral prefrontal cortices, whereas functional coupling between parietal and ventral visual (and also left lateral prefrontal and parietal) cortices was enhanced in the same context. Thus, when controlling for recognition point and stimulus information, activity in ventral visual cortex mirrors recognition success, independent of condition. Facilitation by top-down cues involves lateral parietal cortex interacting with ventral visual areas, potentially explaining why parietal lesions can lead to deficits in recognizing degraded objects even in the context of top-down knowledge.
Subject(s)
Visual Cortex/physiology , Visual Perception/physiology , Adult , Data Interpretation, Statistical , Female , Functional Laterality/physiology , Humans , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Male , Parietal Lobe/physiology , Recognition, Psychology/physiologyABSTRACT
In this critique, we review the usefulness of functional localising scans in functional MRI studies. We consider their conceptual motivations and the implications for experimental design and inference. Functional localisers can often be viewed as acquiring data from cells that have been removed from an implicit factorial design. This perspective reveals their potentially restrictive nature. We deconstruct two examples from the recent literature to highlight the key issues. We conclude that localiser scans can be unnecessary and, in some instances, lead to a biased and inappropriately constrained characterisation of functional anatomy.
Subject(s)
Brain Mapping , Image Processing, Computer-Assisted/instrumentation , Magnetic Resonance Imaging/instrumentation , Cerebral Cortex/anatomy & histology , Cerebral Cortex/physiology , Depth Perception/physiology , Discrimination, Psychological/physiology , Humans , Mathematical Computing , Occipital Lobe/anatomy & histology , Occipital Lobe/physiology , Orientation/physiology , Pattern Recognition, Visual/physiology , Radiosurgery/instrumentation , Sensitivity and Specificity , Surgery, Computer-Assisted/instrumentationABSTRACT
Face recognition across different viewing conditions is strongly improved by familiarity. In the present study, we tested the hypothesis that the neural basis of this effect is a less view-dependent representation of familiar faces in ventral visual cortex by assessing priming-related fMRI repetition effects. 15 healthy volunteers made male/female judgements on familiar (famous) and unfamiliar (novel) faces preceded by the same image, a different image of the same face, or another (unprimed) face. Reaction times revealed priming by same and different images independent of familiarity and more pronounced for same than different images. In the imaging data, a main effect of prime condition was found in bilateral fusiform and orbitofrontal regions. A right anterior fusiform region expressed stronger response decreases to repetition of familiar than unfamiliar faces. Bilateral mid-fusiform areas showed stronger response decreases to repetition of same than different images. A regions-of-interest analysis focussing specifically on face responsive regions suggested differences in the degree of image dependency across fusiform cortex. Collapsing across familiarity, there was greater image dependency of repetition effects in right than left anterior fusiform, replicating previous imaging findings obtained with common objects. For familiar faces alone, there was greater generalisation of repetition effects over different images in anterior than middle fusiform. This suggests a role of anterior fusiform cortex in coding image-independent representations of familiar faces.
Subject(s)
Recognition, Psychology/physiology , Visual Cortex/physiology , Adult , Brain Mapping , Cerebrovascular Circulation/physiology , Cues , Face , Female , Humans , Image Interpretation, Computer-Assisted , Magnetic Resonance Imaging , MaleABSTRACT
Functional neuroimaging studies reveal differences in neural correlates of the retrieval of emotional and nonemotional memories. In the present experiment, encoding of emotionally neutral pictures in association with positively, neutrally or negatively valenced background contexts led to differential modulation of neural activity elicited in a subsequent recognition memory test for these pictures. Recognition of stimuli previously studied in emotional compared to neutral contexts elicited enhanced activity in structures previously implicated in episodic memory, including the parahippocampal cortex, hippocampus and prefrontal cortex. In addition, there was engagement of structures linked more specifically to emotional processing, including the amygdala, orbitofrontal cortex and anterior cingulate cortex. These emotion-related effects displayed both valence-independent and valence-specific components. We discuss the findings in terms of current models of emotional memory retrieval.
Subject(s)
Brain Mapping/methods , Emotions/physiology , Memory/physiology , Adolescent , Adult , Analysis of Variance , Arousal/physiology , Functional Laterality , Humans , Magnetic Resonance Imaging/methods , Pattern Recognition, Visual , Reaction Time/physiology , Reproducibility of ResultsABSTRACT
The distributed model of face processing proposes an anatomical dissociation between brain regions that encode invariant aspects of faces, such as identity, and those that encode changeable aspects of faces, such as expression. We tested for a neuroanatomical dissociation for identity and expression in face perception using a functional MRI (fMRI) adaptation paradigm. Repeating identity across face pairs led to reduced fMRI signal in fusiform cortex and posterior superior temporal sulcus (STS), whereas repeating emotional expression across pairs led to reduced signal in a more anterior region of STS. These results provide neuroanatomical evidence for the distributed model of face processing and highlight a dissociation within right STS between a caudal segment coding identity and a more rostral region coding emotional expression.
Subject(s)
Adaptation, Biological/physiology , Magnetic Resonance Imaging/methods , Neurons/physiology , Photic Stimulation/methods , Visual Perception/physiology , Adolescent , Adult , Analysis of Variance , Face , Female , Humans , Linear Models , MaleABSTRACT
Functional imaging studies of priming-related repetition phenomena have become widely used to study neural object representation. Although blood oxygenation level-dependent (BOLD) repetition decreases can sometimes be observed without awareness of repetition, any role for spatial attention in BOLD repetition effects remains largely unknown. We used fMRI in 13 healthy subjects to test whether BOLD repetition decreases for repeated objects in ventral visual cortices depend on allocation of spatial attention to the prime. Subjects performed a size-judgment task on a probe object that had been attended or ignored in a preceding prime display of 2 lateralized objects. Reaction times showed faster responses when the probe was the same object as the attended prime, independent of the view tested (identical vs. mirror image). No behavioral effect was evident from unattended primes. BOLD repetition decreases for attended primes were found in lateral occipital and fusiform regions bilaterally, which generalized across identical and mirror-image repeats. No repetition decreases were observed for ignored primes. Our results suggest a critical role for attention in achieving visual representations of objects that lead to both BOLD signal decreases and behavioral priming on repeated presentation.
Subject(s)
Attention/physiology , Brain Mapping , Magnetic Resonance Imaging , Oxygen/blood , Space Perception/physiology , Visual Cortex/blood supply , Adult , Female , Functional Laterality , Humans , Male , Photic Stimulation , Reaction Time , Size Perception/physiologyABSTRACT
The modulation of repetition effects by the lag between first and second presentations of a visual object during a speeded semantic judgment task was examined using both scalp event-related potentials (ERPs) and event-related functional magnetic resonance imaging (efMRI). Four levels of lag were used within a single session, from zero to one, to tens of intervening stimuli, and which allowed partial separation of the effects of interference from the effects of time. Reaction times (RTs) showed that the magnitude of repetition priming decreased as lag increased. The ERP data showed two distinct effects of repetition, one between 150 and 300 ms post stimulus and another between 400 and 600 ms. The magnitude of both effects, particularly the earlier one, decreased as lag increased. The fMRI data showed a decrease in the haemodynamic response associated with repetition in several inferior occipitotemporal regions, the magnitude of which also typically decreased as lag increased. In general, and contrary to expectations, lag appeared to have mainly quantitative effects on the three types of dependent variable: there was little evidence for qualitative differences in the neural correlates of repetition effects at different lags.
Subject(s)
Attention/physiology , Cerebral Cortex/physiology , Color Perception/physiology , Discrimination Learning/physiology , Electroencephalography , Hemodynamics/physiology , Image Processing, Computer-Assisted , Imaging, Three-Dimensional , Magnetic Resonance Imaging , Memory, Short-Term/physiology , Pattern Recognition, Visual/physiology , Reaction Time/physiology , Signal Processing, Computer-Assisted , Size Perception/physiology , Adult , Arousal/physiology , Brain Mapping , Dominance, Cerebral/physiology , Evoked Potentials, Visual/physiology , Female , Humans , Male , Occipital Lobe/physiology , Oxygen/blood , Psychophysics , Temporal Lobe/physiology , Visual Pathways/physiologyABSTRACT
This article reviews functional neuroimaging studies of priming, a behavioural change associated with the repeated processing of a stimulus. Using the haemodynamic techniques of functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), priming-related effects have been observed in numerous regions of the human brain, with the specific regions depending on the type of stimulus and the manner in which it is processed. The most common finding is a decreased haemodynamic response for primed versus unprimed stimuli, though priming-related response increases have been observed. Attempts have been made to relate these effects to a form of implicit or "unconscious" memory. The priming-related decrease has also been used as a tool to map the brain regions associated with different stages of stimulus-processing, a method claimed to offer superior spatial resolution. This decrease has a potential analogue in the stimulus repetition effects measured with single-cell recording in the non-human primate. The paradigms reviewed include word-stem completion, masked priming, repetition priming of visual objects and semantic priming. An attempt is made to relate the findings within a "component process" framework, and the relationship between behavioural, haemodynamic and neurophysiological data is discussed. Interpretation of the findings is not always clear-cut, however, given potential confounding factors such as explicit memory, and several recommendations are made for future neuroimaging studies of priming.