1.
Microbes Infect
; 23(4-5): 104808, 2021.
Article
in English
| MEDLINE
| ID: mdl-33753206
ABSTRACT
An unusual clonal gammopathy was reported in COVID-19 patient but whether this anomaly is related or not to the disease has not yet been clarified. To this aim, we selected a cohort of 35 COVID-19 patients swab positive and investigated serological levels of IL-6, immune response to major viral antigens and electrophoretic profile. Elevated levels of IL-6 were accompanied by a significative humoral response to viral Spike protein, revealing an altered electrophoretic profile in the gamma region. We can conclude that elevated levels of IL-6 triggers humoral response inducing a transient plasma cell dyscrasia in severe COVID-19 patients.
Subject(s)
COVID-19/complications , Interleukin-6/immunology , Paraproteinemias/virology , Aged , Antibodies, Viral/blood , COVID-19/immunology , Coronavirus Nucleocapsid Proteins/immunology , Female , Humans , Italy , Male , Paraproteinemias/immunology , Phosphoproteins/immunology , Spike Glycoprotein, Coronavirus/immunology
2.
Mediterr J Hematol Infect Dis
; 10(1): e2018059, 2018.
Article
in English
| MEDLINE
| ID: mdl-30416691