1.
BMJ Case Rep
; 17(4)2024 Apr 30.
Article
in English
| MEDLINE
| ID: mdl-38688578
ABSTRACT
We present the case of a pregnant woman in her 20s who presented in her second trimester with severe pulmonary haemorrhage and dialysis-dependent acute kidney failure due to antiglomerular basement membrane (GBM) disease. Responding to therapy, she recovered kidney function and delivered a baby. During her pregnancy, she developed cytomegalovirus viraemia, gestational diabetes and pre-eclampsia. Here, we report the first combined use of cyclophosphamide, rituximab and intensified plasma exchange in anti-GBM disease in pregnancy, allowing minimal exposure to cytotoxic medication, resulting in live birth and dialysis independence.
Subject(s)
Anti-Glomerular Basement Membrane Disease , Cyclophosphamide , Pregnancy Complications , Humans , Female , Pregnancy , Anti-Glomerular Basement Membrane Disease/diagnosis , Anti-Glomerular Basement Membrane Disease/complications , Anti-Glomerular Basement Membrane Disease/therapy , Pregnancy Complications/drug therapy , Cyclophosphamide/therapeutic use , Adult , Plasma Exchange/methods , Rituximab/therapeutic use , Immunosuppressive Agents/therapeutic use , Acute Kidney Injury/etiology
2.
Clin Teach
; 20(4): e13585, 2023 08.
Article
in English
| MEDLINE
| ID: mdl-37194383