ABSTRACT
The observation of 38 children with early form of children epilepsy that is with syndrome of infantile spasms (IS) was performed by means of computed tomography of the brain. The structural alterations of the brain were revealed in 89.5% of cases. They varied from rough developmental anomalies and pronounced destructive phenomena to microdysgenesias and moderate cortical atrophies. These changes were systematized according to the time of the beginning of some alteration on the definite stage of neuro-ontogenesis. There were embryofetal disturbances (23.6%), peri- and postnatal alterations (50%) and combined ones (15.7%). The definite correlation was established between neuroradiological damages, clinical pattern of IS, differentiated policy of the treatment and the prognosis of neuropsychic development of a child.
Subject(s)
Brain/diagnostic imaging , Spasms, Infantile/diagnostic imaging , Brain/abnormalities , Child, Preschool , Female , Humans , Infant , Male , Prognosis , Spasms, Infantile/etiology , Tomography, X-Ray ComputedSubject(s)
Abnormalities, Multiple/diagnosis , Agenesis of Corpus Callosum , Macular Degeneration/diagnosis , Spasms, Infantile/diagnosis , Abnormalities, Multiple/genetics , Child, Preschool , Female , Genetic Linkage , Humans , Infant , Macular Degeneration/genetics , Spasms, Infantile/genetics , Syndrome , X ChromosomeSubject(s)
Brain/abnormalities , Epilepsy/etiology , Hemiplegia/etiology , Seizures/etiology , Brain/diagnostic imaging , Child, Preschool , Electroencephalography , Epilepsy/diagnosis , Hemiplegia/diagnosis , Humans , Male , Neurologic Examination , Seizures/diagnosis , Syndrome , Tomography, X-Ray ComputedABSTRACT
Observation's analysis of 5 children in age from 9 months to 4 years 11 months with tuberous sclerosis was performed. The initial manifestations of disease were following: early children form of epilepsy exactly infantile spasms (West syndrome) appearance, dermal alterations in the form of depigmented spots as well as nonprogressive delay in psychoverbal development. Together with clinical symptoms the main criterion in early form of tuberous sclerosis diagnosis determination turned out to be brain's specific alterations (tubers) which were revealed by computer tomography. The correlation was observed between epileptic seizures polymorphism and frequency as well as brain's morphological alterations. Derivatives of valproic acid were the basic drugs in treatment of epileptic seizures in patients.
Subject(s)
Spasms, Infantile/diagnosis , Tuberous Sclerosis/diagnosis , Anticonvulsants/therapeutic use , Child, Preschool , Diagnosis, Differential , Female , Humans , Infant , Male , Spasms, Infantile/drug therapy , Spasms, Infantile/genetics , Syndrome , Tuberous Sclerosis/drug therapy , Tuberous Sclerosis/geneticsABSTRACT
The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy. Twelve of them had infantile spasms, four Lennox-Gastaut syndrome. The treatment produced good results in 75% of the patients. Encorat mono- or polychemotherapy is able to discontinue or decrease the frequency of the epileptic fits, improve the patients' condition in resistant early childhood epilepsy.