1.
Tsitol Genet
; 34(1): 15-22, 2000.
Article
Uk
| MEDLINE
| ID: mdl-10808537
The direct dependence between p53 expression in epithelial cells and the level of morphological malignant neoplasm was established as the result of investigation of expression of this biomolecular marker in 12 polyps and 35 colorectal cancer. It was shown that family cancer syndrome 1 type was observed in pedigrees of majority patients with p53 positive cancers.
Colonic Polyps/genetics , Colorectal Neoplasms/genetics , Gene Expression Regulation, Neoplastic/physiology , Intestinal Mucosa/metabolism , Intestine, Large/metabolism , Tumor Suppressor Protein p53/metabolism , Adult , Aged , Colonic Polyps/metabolism , Colonic Polyps/pathology , Colorectal Neoplasms/metabolism , Colorectal Neoplasms/pathology , Epithelium/metabolism , Epithelium/pathology , Female , Humans , Immunohistochemistry , Intestinal Mucosa/pathology , Intestine, Large/pathology , Male , Middle Aged , Pedigree