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Clin Exp Dermatol ; 47(9): 1726-1728, 2022 Sep.
Article in English | MEDLINE | ID: mdl-35596537

ABSTRACT

The protein long interspersed nuclear elements-1 (LINE-1) serves as a useful surrogate marker of global methylation but little is known for Merkel cell carcinoma. LINE-1 expression was found only in Merkel cell polyomavirus (MCPyV)-positive Merkel cell carcinomas but not in MCPyV-negative Merkel cell carcinomas, suggesting that epigenetic dysregulation may be associated with MCPyV expression.


Subject(s)
Carcinoma, Merkel Cell , Merkel cell polyomavirus , Polyomavirus Infections , Skin Neoplasms , Tumor Virus Infections , Biomarkers , Carcinoma, Merkel Cell/genetics , Carcinoma, Merkel Cell/pathology , Humans , Merkel cell polyomavirus/genetics , Skin Neoplasms/pathology
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