Soliton-effect compression of picosecond pulses on a photonic chip.

We report soliton-effect pulse compression of low energy (∼25pJ), picosecond pulses on a photonic chip. An ultra-low-loss, dispersion-engineered 40-cm-long waveguide is used to compress 1.2-ps pulses by a factor of 18, which represents, to our knowledge, the largest compression factor yet experimentally demonstrated on-chip. Our scheme allows for interfacing with an on-chip picosecond source and offers a path towards a fully integrated stabilized frequency comb source.

Performance scaling of a 10-GHz solid-state laser enabling self-referenced CEO frequency detection without amplification.

A simple and compact straight-cavity laser oscillator incorporating a cascaded quadratic nonlinear crystal and a semiconductor saturable absorber mirror (SESAM) can deliver stable femtosecond modelocking at high pulse repetition rates >10 GHz. In this paper, we experimentally investigate the influence of intracavity dispersion, pump brightness, and cavity design on modelocking with high repetition rates, and use the resulting insights to demonstrate a 10.4-GHz straight-cavity SESAM-modelocked Yb:CALGO laser delivering 108-fs pulses with 812 mW of average output power. This result represents a record-level performance for diode-pumped femtosecond oscillators with repetition rates above 10 GHz. Using the oscillator output without any optical amplification, we demonstrate coherent octave-spanning supercontinuum generation (SCG) in a silicon nitride waveguide. Subsequent f-to-2f interferometry with a periodically poled lithium niobate waveguide enables the detection of a strong carrier-envelope offset (CEO) beat note with a 33-dB signal-to-noise ratio.

Chip-based frequency comb sources for optical coherence tomography.

Optical coherence tomography (OCT) is a powerful interferometric imaging technique widely used in medical fields such as ophthalmology, cardiology and dermatology. Superluminescent diodes (SLDs) are widely used as light sources in OCT. Recently integrated chip-based frequency combs have been demonstrated in numerous platforms and the possibility of using these broadband chip-scale combs for OCT has been raised extensively over the past few years. However, the use of these chip-based frequency combs as light sources for OCT requires bandwidth and power compatibility with current OCT systems and have not been shown to date. Here we generate frequency combs based on chip-scale lithographically-defined microresonators and demonstrate its capability as a novel light source for OCT. The combs are designed with a small spectral line spacing of 0.21 nm which ensure imaging range comparable to commercial system and operated at non-phase locked regime which provide conversion efficiency of 30%. The comb source is shown to be compatible with a standard commercial spectral domain (SD) OCT system and enables imaging of human tissue with image quality comparable to the one achieved with tabletop commercial sources. The comb source also provides a path towards fully integrated OCT systems.

Carrier envelope offset detection via simultaneous supercontinuum and second-harmonic generation in a silicon nitride waveguide.

We demonstrate a chip-scale f-2f interferometer for carrier-envelope-offset frequency (fCEO) detection. This is enabled by simultaneously producing octave-spanning coherent supercontinuum generation and second-harmonic generation in a single dispersion-engineered silicon nitride waveguide. We measure the fCEO beatnote of an 80 MHz modelocked pump source with a signal-to-noise ratio of 25 dB. Our simple approach for f-2f interferometry enables a straightforward route towards a chip-scale self-referenced frequency comb source that can operate at low pulse energies.

Counter-rotating cavity solitons in a silicon nitride microresonator.

We demonstrate the generation of counter-rotating cavity solitons in a silicon nitride microresonator using a fixed, single-frequency laser. We demonstrate a dual three-soliton state with a difference in the repetition rates of the soliton trains that can be tuned by varying the ratio of pump powers in the two directions. Such a system enables a highly compact, tunable dual comb source that can be used for applications such as spectroscopy and distance ranging.

Gigahertz frequency comb offset stabilization based on supercontinuum generation in silicon nitride waveguides.

Silicon nitride (Si3N4) waveguides represent a novel photonic platform that is ideally suited for energy efficient and ultrabroadband nonlinear interactions from the visible to the mid-infrared. Chip-based supercontinuum generation in Si3N4 offers a path towards a fully-integrated and highly compact comb source for sensing and time-and-frequency metrology applications. We demonstrate the first successful frequency comb offset stabilization that utilizes a Si3N4 waveguide for octave-spanning supercontinuum generation and achieve the lowest integrated residual phase noise of any diode-pumped gigahertz laser comb to date. In addition, we perform a direct comparison to a standard silica photonic crystal fiber (PCF) using the same ultrafast solid-state laser oscillator operating at 1 µm. We identify the minimal role of Raman scattering in Si3N4 as a key benefit that allows to overcome the fundamental limitations of silica fibers set by Raman-induced self-frequency shift.

Thermally controlled comb generation and soliton modelocking in microresonators.

We report, to the best of our knowledge, the first demonstration of thermally controlled soliton mode-locked frequency comb generation in microresonators. By controlling the electric current through heaters integrated with silicon nitride microresonators, we demonstrate a systematic and repeatable pathway to single- and multi-soliton mode-locked states without adjusting the pump laser wavelength. Such an approach could greatly simplify the generation of mode-locked frequency combs and facilitate applications such as chip-based dual-comb spectroscopy.

Dual-comb modelocked lasers: semiconductor saturable absorber mirror decouples noise stabilization.

In this paper we present the stabilization of the pulse repetition rate of dual-comb lasers using an intracavity semiconductor saturable absorber mirror (SESAM) for passive modelocking and an intracavity birefringent crystal for polarization-duplexing to obtain simultaneous emission of two modelocked beams from the same linear cavity sharing all components. Initially surprising was the observation that the cavity length adjustments to stabilize one polarization did not significantly affect the pulse repetition rate of the other. We gained insight in the underlying physics using both a semiconductor and Nd:YAG laser gain material with the conclusion that the pulse arrival timing jitter of the two beams is decoupled by the uncorrelated time delay from the saturated SESAM and becomes locked with sufficient but not too much pulse overlap. Noise stabilization is in all cases still possible for both combs. The dual-comb modelocked laser is particularly interesting for the semiconductor laser enabling the integration of gain and absorber layers within one wafer (referred to as the modelocked integrated external-cavity surface emitting laser--MIXSEL).

Octave-spanning coherent supercontinuum generation in a silicon nitride waveguide.

We demonstrate the generation of a supercontinuum spanning more than 1.4 octaves in a silicon nitride waveguide using sub-100-fs pulses at 1 µm generated by either a 53-MHz, diode-pumped ytterbium (Yb) fiber laser or a 1-GHz, Yb:CaAlGdO(4) (Yb:CALGO) laser. Our numerical simulations show that the broadband supercontinuum is fully coherent, and a spectral interference measurement is used to verify that the supercontinuum generated with the Yb:CALGO laser possesses a high degree of coherence over the majority of its spectral bandwidth. This coherent spectrum may be utilized for optical coherence tomography, spectroscopy, and frequency metrology.

Frequency comb offset dynamics of SESAM modelocked thin disk lasers.

We present a detailed study of the carrier-envelope offset (CEO) frequency dynamics of SESAM modelocked thin disk lasers (TDLs) pumped by kW-class highly transverse multimode pump diodes with a typical M(2) value of 200-300, and give guidelines for future frequency stabilization of multi-100-W oscillators. We demonstrate CEO frequency detection with > 30 dB signal-to-noise ratio with a resolution bandwidth of 100 kHz from a SESAM modelocked Yb:YAG TDL delivering 140 W average output power with 748-fs pulses at 7-MHz pulse repetition rate. We compare with a low-power CEO frequency stabilized Yb:CALGO TDL delivering 2.1 W with 77-fs pulses at 65 MHz. For both lasers, we perform a complete noise characterization, measure the relevant transfer functions (TFs) and compare them to theoretical models. The measured TFs are used to determine the propagation of the pump noise step-by-step through the system components. From the noise propagation analysis, we identify the relative intensity noise (RIN) of the pump diode as the main contribution to the CEO frequency noise. The resulting noise levels are not excessive and do not prevent CEO frequency stabilization. More importantly, the laser cavity dynamics are shown to play an essential role in the CEO frequency dynamics. The cavity TFs of the two lasers are very different which explains why at this point a tight CEO frequency lock can be obtained with the Yb:CALGO TDL but not with the Yb:YAG TDL. For CEO stabilization laser cavities should exhibit high damping of the relaxation oscillations by nonlinear intra-cavity elements, for example by operating a SESAM in the roll-over regime. Therefore the optimum SESAM operation point is a trade-off between enough damping and avoiding multiple pulsing instabilities. Additional cavity components could be considered for supplementary damping independent of the SESAM operation point.

All-optical Q-switching limiter for high-power gigahertz modelocked diode-pumped solid-state lasers.

Passively modelocked diode-pumped solid-state lasers (DPSSLs) with pulse repetition rates in the gigahertz regime suffer from an increased tendency for Q-switching instabilities. Low saturation fluence intracavity saturable absorbers - such as the semiconductor saturable absorber mirrors (SESAMs) - can solve this problem up to a certain average output power limited by the onset of SESAM damage. Here we present a passive stabilization mechanism, an all-optical Q-switching limiter, to reduce the impact of Q-switching instabilities and increase the potential output power of SESAM modelocked lasers in the gigahertz regime. With a proper cavity design a Kerr lens induced negative saturable absorber clamps the maximum fluence on the SESAM and therefore limits the onset of Q-switching instabilities. No critical cavity alignment is required because this Q-switching limiter acts well within the cavity stability regime. Using a proper cavity design, a high-power diode-pumped Yb:CALGO solid-state laser generated sub-100 fs pulses with an average output power of 4.1 W at a pulse repetition rate of 5 GHz. With a pulse duration of 96 fs we can achieve a peak power as high as 7.5 kW directly from the SESAM modelocked laser oscillator without any further external pulse amplification and/or pulse compression. We present a quantitative analysis of this Kerr lens induced Q-switching limiter and its impact on modelocked operation. Our work provides a route to compact high-power multi-gigahertz frequency combs based on SESAM modelocked diode-pumped solid-state lasers without any additional external amplification or pulse compression.

Dual-comb modelocked laser.

In this paper we present the first semiconductor disk laser (SDL) emitting simultaneously two collinearly overlapping cross-polarized gigahertz modelocked pulse trains with different pulse repetition rates. Using only a simple photo detector and a microwave spectrum analyzer directly down-converts the frequency comb difference from the optical to the microwave frequency domain. With this setup, the relative carrier-envelope-offset (CEO) frequency can be accessed directly without an f-to2f interferometer. A very compact design is obtained using the modelocked integrated external-cavity surface emitting laser (MIXSEL) which is part of the family of optically pumped SDLs and similar to a vertical external cavity surface emitting laser (VECSEL) but with both gain and saturable absorber integrated into the same semiconductor wafer (i.e. MIXSEL chip). We then simply added an additional intracavity birefringent crystal inside the linear straight cavity between the output coupler and the MIXSEL chip which splits the cavity beam into two collinear but spatially separated cross-polarized beams on the MIXSEL chip. This results in two modelocked collinear and fully overlapping cross-polarized output beams with adjustable pulse repetition frequencies with excellent noise performance. We stabilized both pulse repetition rates of the dual comb MIXSEL.

Annotated chemical patent corpus: a gold standard for text mining.

Exploring the chemical and biological space covered by patent applications is crucial in early-stage medicinal chemistry activities. Patent analysis can provide understanding of compound prior art, novelty checking, validation of biological assays, and identification of new starting points for chemical exploration. Extracting chemical and biological entities from patents through manual extraction by expert curators can take substantial amount of time and resources. Text mining methods can help to ease this process. To validate the performance of such methods, a manually annotated patent corpus is essential. In this study we have produced a large gold standard chemical patent corpus. We developed annotation guidelines and selected 200 full patents from the World Intellectual Property Organization, United States Patent and Trademark Office, and European Patent Office. The patents were pre-annotated automatically and made available to four independent annotator groups each consisting of two to ten annotators. The annotators marked chemicals in different subclasses, diseases, targets, and modes of action. Spelling mistakes and spurious line break due to optical character recognition errors were also annotated. A subset of 47 patents was annotated by at least three annotator groups, from which harmonized annotations and inter-annotator agreement scores were derived. One group annotated the full set. The patent corpus includes 400,125 annotations for the full set and 36,537 annotations for the harmonized set. All patents and annotated entities are publicly available at www.biosemantics.org.

Gigahertz self-referenceable frequency comb from a semiconductor disk laser.

We present a 1.75-GHz self-referenceable frequency comb from a vertical external-cavity surface-emitting laser (VECSEL) passively modelocked with a semiconductor saturable absorber mirror (SESAM). The VECSEL delivers 231-fs pulses with an average power of 100 mW and is optimized for stable and reliable operation. The optical spectrum was centered around 1038 nm and nearly transform-limited with a full width half maximum (FWHM) bandwidth of 5.5 nm. The pulses were first amplified to an average power of 5.5 W using a backward-pumped Yb-doped double-clad large mode area (LMA) fiber and then compressed to 85 fs with 2.2 W of average power with a passive LMA fiber and transmission gratings. Subsequently, we launched the pulses into a highly nonlinear photonic crystal fiber (PCF) and generated a coherent octave-spanning supercontinuum (SC). We then detected the carrier-envelope offset (CEO) frequency (f(CEO)) beat note using a standard f-to-2f-interferometer. The f(CEO) exhibits a signal-to-noise ratio of 17 dB in a 100-kHz resolution bandwidth and a FWHM of ≈10 MHz. To our knowledge, this is the first report on the detection of the f(CEO) from a semiconductor laser, opening the door to fully stabilized compact frequency combs based on modelocked semiconductor disk lasers.

High peak power gigahertz Yb:CALGO laser.

We present a high-power gigahertz SESAM modelocked Yb:CALGO laser with sub-60-fs pulses. The laser delivers an average output power of 2.95 W at a pulse repetition rate of 1.8 GHz in fundamental modelocking without additional pulse compression or amplification. Stable modelocking with a single pulse per cavity round-trip is confirmed and results in an output peak power of 24.3 kW and a pulse energy of 1.64 nJ. The laser is pumped by a commercial multimode diode laser, which improves the reliability and robustness. This high-power gigahertz laser is expected to enable numerous applications in frequency metrology.

Gigahertz frequency comb from a diode-pumped solid-state laser.

We present the first stabilization of the frequency comb offset from a diode-pumped gigahertz solid-state laser oscillator. No additional external amplification and/or compression of the output pulses is required. The laser is reliably modelocked using a SESAM and is based on a diode-pumped Yb:CALGO gain crystal. It generates 1.7-W average output power and pulse durations as short as 64 fs at a pulse repetition rate of 1 GHz. We generate an octave-spanning supercontinuum in a highly nonlinear fiber and use the standard f-to-2f carrier-envelope offset (CEO) frequency fCEO detection method. As a pump source, we use a reliable and cost-efficient commercial diode laser. Its multi-spatial-mode beam profile leads to a relatively broad frequency comb offset beat signal, which nevertheless can be phase-locked by feedback to its current. Using improved electronics, we reached a feedback-loop-bandwidth of up to 300 kHz. A combination of digital and analog electronics is used to achieve a tight phase-lock of fCEO to an external microwave reference with a low in-loop residual integrated phase-noise of 744 mrad in an integration bandwidth of [1 Hz, 5 MHz]. An analysis of the laser noise and response functions is presented which gives detailed insights into the CEO stabilization of this frequency comb.

Phase-stabilization of the carrier-envelope-offset frequency of a SESAM modelocked thin disk laser.

We phase-stabilized the carrier-envelope-offset (CEO) frequency of a SESAM modelocked Yb:CaGdAlO4 (CALGO) thin disk laser (TDL) generating 90-fs pulses at a center wavelength of 1051.6 nm and a repetition rate of 65 MHz. By launching only 2% of its output power into a photonic crystal fiber, we generated a coherent octave-spanning supercontinuum spectrum. Using a standard f-to-2f interferometer for CEO detection, we measured CEO beats with 33 dB signal-to-noise ratio in 100 kHz resolution bandwidth. We achieved a tight lock of the CEO frequency at 26.18 MHz by active feedback to the pump current. The residual in-loop integrated phase noise is 120 mrad (1 Hz-1 MHz). This is, to our knowledge, the first CEO-stabilized SESAM modelocked TDL. Our results show that a reliable lock of the CEO frequency can be achieved using standard techniques in spite of the strongly spatially multimode pumping scheme of TDLs. This opens the door towards fully-stabilized low-noise frequency combs with hundreds of watts of average power from table-top SESAM modelocked thin disk oscillators.

A gigahertz multimode-diode-pumped Yb:KGW enables a strong frequency comb offset beat signal.

A high-power gigahertz SESAM modelocked Yb:KGW laser is pumped with a commercial multimode diode laser and enables a strong frequency comb offset beat signal without additional amplification or pulse compression. The ultrafast Yb:KGW solid-state laser oscillator generates 125-fs pulses at an average power of 3.4 W and a repetition rate of 1.06 GHz with a record-high peak power of 22.7 kW. An octave-spanning frequency comb was generated with a 1-m long highly nonlinear photonic crystal fiber (PCF) launching only 900 mW of the total average power with a PCF coupling efficiency of 70%. The frequency comb offset was successfully detected with a carrier-envelope offset (CEO) frequency beat signal of 30-dB signal-to-noise ratio for a resolution bandwidth of 100 kHz. The robust and simple pumping scheme based on a commercially available multimode diode laser makes this laser attractive for future frequency comb metrology applications.

SVM Based Descriptor Selection and Classification of Neurodegenerative Disease Drugs for Pharmacological Modeling.

Systems pharmacological modeling of drug mode of action for the next generation of multitarget drugs may open new routes for drug design and discovery. Computational methods are widely used in this context amongst which support vector machines (SVM) have proven successful in addressing the challenge of classifying drugs with similar features. We have applied a variety of such SVM-based approaches, namely SVM-based recursive feature elimination (SVM-RFE). We use the approach to predict the pharmacological properties of drugs widely used against complex neurodegenerative disorders (NDD) and to build an in-silico computational model for the binary classification of NDD drugs from other drugs. Application of an SVM-RFE model to a set of drugs successfully classified NDD drugs from non-NDD drugs and resulted in overall accuracy of ∼80 % with 10 fold cross validation using 40 top ranked molecular descriptors selected out of total 314 descriptors. Moreover, SVM-RFE method outperformed linear discriminant analysis (LDA) based feature selection and classification. The model reduced the multidimensional descriptors space of drugs dramatically and predicted NDD drugs with high accuracy, while avoiding over fitting. Based on these results, NDD-specific focused libraries of drug-like compounds can be designed and existing NDD-specific drugs can be characterized by a well-characterized set of molecular descriptors.

Femtosecond diode-pumped solid-state laser with a repetition rate of 4.8 GHz.

We report on a diode-pumped Yb:KGW (ytterbium-doped potassium gadolinium tungstate) laser with a repetition rate of 4.8 GHz and a pulse duration of 396 fs. Stable fundamental modelocking is achieved with a semiconductor saturable absorber mirror (SESAM). The average output power of this compact diode-pumped solid state laser is 1.9 W which corresponds to a peak power of 0.9 kW and the optical-to-optical efficiency is 36%. To the best of our knowledge, this is the femtosecond DPSSL with the highest repetition rate ever reported so far.