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Pak J Pharm Sci ; 37(2): 315-320, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38767098

ABSTRACT

The present study was designed to assess Tradescantia spathacea's antidiabetic ability, as well as the antiulcer activity of the entire plant extract. The diabetic condition was evaluated using Streptozotocin's oral glucose tolerance test, diabetes-alloxan and diabetes-models. Antiulcer activities were observed in rats where gastric ulcers were either caused by oral administration of ethanol, or pyloric ligation. Standards include ranitidine, glibenclamide and sucralfate. In all models, the blood glucose levels of animals treated with the test extract were found to be significantly lower compared to diabetic care. Similarly, in all models, the ulcer index in the animals treated with the test extract was found to be significantly lower relative to the animals under vehicle supervision. Our findings say T. Spathacea extract has essential anti-diabetic properties, as well as antiulcer properties.


Subject(s)
Anti-Ulcer Agents , Blood Glucose , Diabetes Mellitus, Experimental , Hypoglycemic Agents , Plant Extracts , Rats, Wistar , Stomach Ulcer , Animals , Hypoglycemic Agents/pharmacology , Hypoglycemic Agents/isolation & purification , Plant Extracts/pharmacology , Plant Extracts/isolation & purification , Anti-Ulcer Agents/pharmacology , Anti-Ulcer Agents/isolation & purification , Diabetes Mellitus, Experimental/drug therapy , Stomach Ulcer/drug therapy , Stomach Ulcer/prevention & control , Stomach Ulcer/pathology , Stomach Ulcer/chemically induced , Male , Rats , Blood Glucose/drug effects , Blood Glucose/metabolism , Methanol/chemistry , Glucose Tolerance Test , Solvents/chemistry , Phytotherapy
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