Subject(s)
Arm/blood supply , Arteriosclerosis Obliterans/immunology , Hypergammaglobulinemia/complications , Immunoglobulin E/biosynthesis , Leg/blood supply , Thromboangiitis Obliterans/immunology , Adult , Arteriosclerosis Obliterans/etiology , Humans , Male , Middle Aged , Thromboangiitis Obliterans/etiologyABSTRACT
Besides cerebrovascular pathology and livedo, cardiac affections are introduced in clinical manifestations of Sneddon's syndrome. They involve coronary heart disease (up to development of MI), murmur (usually mitral), occasional cardiac arrhythmia. Patients with coronary disease and cardiac murmur show antibodies to cardiolipin significantly more frequently. The role of antibodies to cardiolipin in the genesis of cardiac alterations in Sneddon's syndrome is open to discussion.
Subject(s)
Autoantibodies/immunology , Autoimmune Diseases/etiology , Cardiolipins/immunology , Cerebrovascular Disorders/complications , Coronary Disease/etiology , Cyanosis/complications , Adolescent , Adult , Autoantibodies/analysis , Autoimmune Diseases/immunology , Cerebrovascular Disorders/immunology , Coronary Disease/immunology , Cyanosis/immunology , Female , Humans , Male , Middle Aged , Skin Diseases/immunology , SyndromeABSTRACT
We studied 24 patients (18 women, 6 men), aged 29 to 54, with Sneddon's syndrome. The clinical picture of Sneddon's syndrome was characterized by cerebrovascular disorders, livedo reticularis, disturbance of peripheral circulation, arterial hypertension, cardiac pathology (ischemic heart disease, heart murmurs), complicated obstetric history in women, and disturbed sexual function in men. In 6 of 17 examined patients with Sneddon's syndrome there was a high concentration of anticardiolipin antibodies (ACA) but no antibodies to native DNA and LE cells. The course of the disease in the patients with a high ACA level, when compared with normal ACA level patients, was characterized by a more rapid progression and more severe clinical manifestations. The study demonstrates the similarity of clinical symptoms and immunologic disturbances in Sneddon's syndrome and the antiphospholipid syndrome and suggests the importance of ACA in the pathogenesis of some cases of Sneddon's syndrome.
Subject(s)
Arterial Occlusive Diseases/immunology , Autoantibodies/analysis , Cardiolipins/immunology , Cerebrovascular Disorders/immunology , Skin Diseases/immunology , Adolescent , Adult , Age Factors , Cerebrovascular Disorders/physiopathology , Female , Humans , Immunoglobulin G/analysis , Male , SyndromeSubject(s)
Coronary Disease/immunology , Hypergammaglobulinemia/etiology , Immunoglobulin E/analysis , Adult , Aged , Coronary Disease/complications , Female , Humans , Male , Middle Aged , PrognosisABSTRACT
It has been shown that prolonged use of plasmapheresis with a 7-day interval in patients with hereditary hypercholesterolemia is potentially dangerous because of possible development of immunodeficiency. LDL plasmasorption and immunosorption produce a beneficial effect on the concentration of immunoglobulins. It is assumed that immunosorption permits the elimination not only of lipoproteins but also lipoprotein-containing immune complexes from the blood channel.