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1.
Int J Surg Pathol ; 20(2): 185-90, 2012 Apr.
Article in English | MEDLINE | ID: mdl-21791485

ABSTRACT

Rhabdoid colon tumors (RCTs) are rare lesions whose existence as an independent distinct entity remains controversial. To date, 6 RCTs have been reported. This study reports a novel case associated with polyposis coli in a 73-year-old woman. Histologically, the neoplasia was heterogeneous consisting of an adenocarcinoma associated with rhabdoid features. In rhabdoid component, an intense expression of MSH2 was noted but MLH1 was negative. A BRAF V600E mutation and no KRAS mutations were identified. The promoter regions of subset of genes highly specific to characterize the CIMP status (NEUROG1, IGF2, RUNX3, SOCS1, including MLH1) were hypermethylated, suggesting the presence of CIMP+ and MSI high tumor. In conclusion, all RCTs have similar clinical features. The presence of polyposis and adenocarcinoma component as well as the expression of mesenchymal marker suggests a sarcomatous dedifferentiation. It is argued that RCT could be a very aggressive entity of colon, which could benefit from new biological colonic treatments.


Subject(s)
Adenocarcinoma/pathology , Adenomatous Polyposis Coli/pathology , Colonic Neoplasms/pathology , Rhabdoid Tumor/pathology , Adenocarcinoma/complications , Adenocarcinoma/therapy , Adenomatous Polyposis Coli/complications , Adenomatous Polyposis Coli/therapy , Aged , Colonic Neoplasms/complications , Colonic Neoplasms/therapy , Combined Modality Therapy , DNA Mutational Analysis , DNA, Neoplasm/analysis , Fatal Outcome , Female , Humans , Rhabdoid Tumor/complications , Rhabdoid Tumor/therapy
2.
Tumori ; 95(1): 101-3, 2009.
Article in English | MEDLINE | ID: mdl-19366066

ABSTRACT

Intraosseous cavernomas are very rare benign lesions representing less than 1% of all skeletal tumors and most frequently observed in vertebrae and head and neck bones. Solitary hemangiomas of the hand bones are exceptionally rare. We report a case of this neoplasm in the distal epiphysis of the third metacarpal bone in a 68-year-old man, along with the clinicopathological findings. The differential diagnosis and a review of the literature are discussed.


Subject(s)
Bone Neoplasms/pathology , Hemangioma, Cavernous/pathology , Metacarpal Bones/pathology , Aged , Bone Neoplasms/surgery , Hemangioma, Cavernous/surgery , Humans , Male , Metacarpal Bones/surgery , Orthopedic Procedures
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