ABSTRACT
Basal cell carcinoma is the most common form of skin cancer, with giant basal cell carcinoma comprising only 0.5 percent of all basal cell carcinomas. When a basal cell carcinoma is larger than 5 cm, it is designated as a giant basal cell carcinoma. Neglect is often a contributing factor to these lesions, and local recurrence and metastasis is not uncommon. Presented is a case of a 66-year-old man who presented with a chief complaint of increasing shortness of breath and fatigue. The patient was found to have a large 15 cm x 12 cm pedunculated tumor on his back that had been present for 10 years. The patient had forgone medical attention until presenting with a symptomatic anemia due to his belief in Christian Science, which relies on prayer and divine healing for the treatment of illness. Christian Scientists are allowed to see physicians, but they may present with advanced symptoms or disease presentations due to their beliefs. Fortunately, a computed tomography (CT) scan revealed that the tumor was confined to the skin, and biopsy revealed a basal cell carcinoma. Thus, the patient was able to undergo a wide local excision and split thickness skin graft with clear surgical margins.
Subject(s)
Carcinoma, Basal Cell/surgery , Christianity , Mental Healing , Skin Neoplasms/surgery , Aged , Back , Carcinoma, Basal Cell/pathology , Free Tissue Flaps , Humans , Male , Skin Neoplasms/pathologyABSTRACT
Primary pleomorphic rhabdomyosarcoma of the uterus is a very rare neoplasm. We describe a 65-year old female with this diagnosis, who underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy and lymph node dissection. Also included is a discussion on the different types of rhabdomyosarcoma with reviews of their histological features, epidemiology and common sites of origin.
Subject(s)
Rhabdomyosarcoma , Uterine Neoplasms , Aged , Female , Humans , Immunohistochemistry , Microscopy, Electron , Ovariectomy , Rhabdomyosarcoma/diagnosis , Rhabdomyosarcoma/diagnostic imaging , Rhabdomyosarcoma/pathology , Rhabdomyosarcoma/surgery , Rhabdomyosarcoma/ultrastructure , Salpingectomy , Tomography, X-Ray Computed , Ultrasonography , Uterine Neoplasms/diagnosis , Uterine Neoplasms/diagnostic imaging , Uterine Neoplasms/pathology , Uterine Neoplasms/surgery , Uterine Neoplasms/ultrastructure , Uterus/pathologyABSTRACT
We describe a 42-year-old male who was in good health until he presented with a high grade B-cell non-Hodgkin lymphoma/leukemia that had both MYC and t(14;18) translocations. This process has now been classified as "B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma," according to the 2008 World Health Organization Classification of Tumours of Haematopoitic and Lymphoid Tissues. The clinical presentation, pathologic work-up including examination of the peripheral blood, lymph node biopsy, bone marrow aspiration and biopsy are included. Treatment consisted of seven cycles of chemotherapy following the CALGB protocol 9251. Prognosis is generally reported as poor in these aggressive "double-hit" lymphomas. However, this patient's disease has now been in remission for two years.
Subject(s)
Burkitt Lymphoma/genetics , Chromosomes, Human, Pair 14/genetics , Chromosomes, Human, Pair 18/genetics , Lymphoma, Large B-Cell, Diffuse/genetics , Proto-Oncogene Proteins c-myc/genetics , Translocation, Genetic , Adult , Humans , Immunohistochemistry , Immunophenotyping , Karyotyping , Ki-67 Antigen/metabolism , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/metabolism , Lymphoma, Large B-Cell, Diffuse/pathology , MaleABSTRACT
Synchronous presentation of breast cancer and lymphoma is extremely rare. Few cases are reported in the literature. We describe a case of invasive ductal carcinoma of the breast with micrometastasis to a non-sentinel lymph node and subsequent incidental finding of a low-grade follicular lymphoma in an axillary node of a 52-year-old woman. The characteristic immunohistochemical profile of the lymphoma is described.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/pathology , Lymphoma, Follicular/pathology , Neoplasms, Multiple Primary/pathology , Antigens, CD20/metabolism , Biopsy, Needle , Female , Humans , Immunohistochemistry , Lymph Nodes/pathology , Lymphocytes/metabolism , Middle AgedABSTRACT
STUDY OBJECTIVE: To describe a rare cause of clitoromegaly. SETTING: University Medical Center. PARTICIPANTS: Patient. INTERVENTION: Magnetic resonance imaging, surgical resection of the cyst, clitoroplasty. RESULTS: Clitoroplasty with removal of the intradermal cyst and resolution of pain. CONCLUSIONS: A 17-year-old immigrant female presented with clitoral pain associated with clitoromegaly. Epidermoid cysts are usually solitary, asymptomatic, slow-growing, proliferations of epidermal cells that are commonly present on the neck, scalp, face, or trunk. There have only been four reported cases of epidermoid cysts of the clitoris not associated with female genital mutilation. The cyst in this case was removed by local excision, and the patient's pain has resolved.