The devolution of the social licence to operate in the Australian mining industry.

The aim of this paper is to present a brief historical analysis of the Australian mining industry and the development of its social licence to operate. Commencing with the discovery of coal in the 18th century, to gold and copper and base metals in the 19th century, to the world class iron ore, mineral sands and diamond mines of the 20th century to the current day, the paper will attempt to determine how and why an industry, formerly well-respected by the public, is considered to be a pariah in the eyes of many sections of society. The theory of social licence and its use in the Australian minerals industry is briefly described and a working definition of "an honest, transparent engagement resulting in a beneficial outcome to all parties before, during and after mining" is adopted throughout the paper. Case studies illustrating examples where mining operations were, and continue to be sustained for decades, provide clear evidence of having a social licence to operate. On the other hand, examples are provided illustrating where poor environmental management practices, tailings dam failures, disputes with landowners, and/or government intervention have resulted in the loss of the social licence and early, unplanned closure. The paradox is that despite the industry's acknowledged contribution to the Australian economy, particularly in times of global ructions such as the GFC and the current coronavirus pandemic, there is considerable antipathy towards the industry by the public. Furthermore, the Australian mining industry's approach to environmental management and sustainable development is regularly used as a model for emerging mining economies. The industry has pioneered remediation and rehabilitation on challenging sites, including prime agricultural land, forests, riverine and beach environments. Successes are rarely acknowledged however but failures are highlighted, by the media, opponents of the industry, and governments. Clearly, the business as usual approach is not enough. Mining industry leaders need to take strong measures to ensure the industry is sustainable and maintains its social licence including eliminating all fatalities and serious injuries, ensuring the safety and stability of tailings storage facilities, accelerating progressive rehabilitation particularly on open cut coal mines, successfully closing mines, and lifting the environmental performance of all mines, not just a few.

Multicenter Validation Study to Implement Plasma Epidermal Growth Factor Receptor T790M Testing in Clinical Laboratories.

PURPOSE: Plasma detection of EGFR T790M mutations is an emerging alternative to tumor rebiopsy in acquired epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor resistance. Validation of analytical sensitivity and clinical utility is required before routine diagnostic use in clinical laboratories. PATIENTS AND METHODS: Sixty-three patients with advanced EGFR-mutant lung cancer at 7 Canadian centers, who were being screened for the ASTRIS trial (ClinicalTrials.gov identifier: NCT02474355), participated in this companion study. Plasma T790M mutation was detected using droplet digital polymerase chain reaction, Cobas (Roche Diagnostics, Indianapolis, IN), or next-generation sequencing in 4 laboratories. T790M concordance was assessed between plasma and tumor samples. RESULTS: Assessment of T790M in tumor biopsy tissue was successful in 81% of patients; 49% had confirmed T790M results (tumor or plasma) for ASTRIS. Plasma testing in this companion study yielded T790M results in 97% of patients; 62% had T790M-positive results, 36% had negative results, and 2% had indeterminate results. Of 38 patients with negative or indeterminate biopsy results, 55% had positive plasma T790M results, increasing the proportion with T790M-positive results to 73%. Sensitivity of plasma T790M testing was 75%. Overall concordance between tissue and plasma was 64%, and concordance among laboratories was 90.3%. Response to osimertinib and duration of therapy were similar irrespective of testing method (overall response rate, 62.5% for tissue, 66.7% for plasma, and 70.6% for both). CONCLUSION: This multicenter validation study demonstrates that plasma EGFR T790M testing can identify significantly more patients than biopsy alone who may benefit from targeted therapy.

Safety rules and regulations on mine sites - the problem and a solution.

INTRODUCTION: Many accidents and incidents on mine sites have a causal factor in the rules and regulations that supposedly are in place to prevent the incident from occurring. The causes involve a lack of awareness or understanding, ignorance, or deliberate violations. The issue of mine rules, procedures, and regulations is a central focus of this paper, highlighted by this recent comment - "very few people have accidents for which there is no procedure in place..." METHOD: An attitudinal survey was conducted at 33 mines throughout NSW, Queensland and international mine sites involving almost 500 mineworkers. The survey was in the form of a self-completing questionnaire, consisting of approximately 65 questions. It aimed to seek the opinions of the mining workforce on safety rules and regulations generally, as well as how they apply to their specific jobs on a mine site. The research also aimed to investigate: (a) the level of awareness and understanding of mine rules and procedures such as manager's rules and safe work procedures (SWPs); (b) the level of awareness and understanding of mine safety regulations and legislation; (c) the extent of communication of and commitment to rules and regulations; (d) the extent of compliance with rules and regulations; and (e) attitudes regarding errors, risk-taking, and accidents and their interaction with rules and regulations. The sample consisted of a random selection of underground and open pit mines, extracting coal, metals, or industrial minerals. RESULTS: The insights provided by the mineworkers enabled a set of principles to be developed to guide mine management and regulators in the development of more effective rules and regulations. CONCLUSIONS AND IMPACT ON THE MINING INDUSTRY: (a) Management and regulators should not continue to produce more and more rules and regulations to cover every aspect of mining. (b) Detailed prescriptive regulations, detailed safe work procedures, and voluminous safety management plans will not "connect" with a miner. (c) Achieving more effective rules and regulations is not the only answer to a safer workplace.