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1.
This kids' brain cancer is incurable - but immune therapy holds promise.
Ledford, Heidi.
Nature ; 631(8022): 715-716, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38997564

Subject(s)
Brain Neoplasms , Immunotherapy, Adoptive , Receptors, Chimeric Antigen , Child, Preschool , Humans , Brain Neoplasms/immunology , Brain Neoplasms/therapy , Receptors, Chimeric Antigen/immunology
2.
Mice live longer when inflammation-boosting protein is blocked.
Ledford, Heidi.
Nature ; 631(8022): 716-717, 2024 Jul.
Article in English | MEDLINE | ID: mdl-39020193

Subject(s)
Inflammation , Interleukin-11 , Longevity , Animals , Humans , Mice , Inflammation/immunology , Interleukin-11/antagonists & inhibitors , Interleukin-11/immunology , Longevity/drug effects , Longevity/immunology , Geroscience
3.
Why cancer risk declines sharply in old age.
Ledford, Heidi.
Nature ; 631(8020): 261-262, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38961208

Subject(s)
Neoplasms , Humans , Neoplasms/epidemiology , Aged , Aging , Female , Male , Risk Factors
4.
Audio long read: Hope, despair and CRISPR - the race to save one woman's life.
Ledford, Heidi; Thompson, Benjamin.
Nature ; 2024 Jul 26.
Article in English | MEDLINE | ID: mdl-39060529
5.
How a few days in space can disrupt a person's biology.
Ledford, Heidi.
Nature ; 630(8017): 536-537, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38862683

Subject(s)
Astronauts , Radiation Injuries , Space Flight , Weightlessness , Humans , Astronauts/statistics & numerical data , Radiation Injuries/epidemiology , Time Factors , Weightlessness/adverse effects , Male , Female
6.
No CRISPR: oddball 'jumping gene' enzyme edits genomes without breaking DNA.
Ledford, Heidi.
Nature ; 631(8020): 470-471, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38937599

Subject(s)
CRISPR-Cas Systems , DNA , Gene Editing , Genome , Interspersed Repetitive Sequences , Humans , DNA/genetics , Gene Editing/methods , Gene Editing/trends , Genome/genetics , DNA Breaks , Interspersed Repetitive Sequences/genetics , Animals
7.
Hope, despair and CRISPR - the race to save one woman's life.
Ledford, Heidi.
Nature ; 630(8016): 284-288, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38867133

Subject(s)
CRISPR-Cas Systems , Gene Editing , Hope , Precision Medicine , Female , Humans , Young Adult , CRISPR-Cas Systems/genetics , Gene Editing/methods , Gene Editing/trends , Precision Medicine/methods , Precision Medicine/trends
8.
The immune system can sabotage gene therapies - can scientists rein it in?
Ledford, Heidi.
Nature ; 630(8015): 13-14, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38806772

Subject(s)
Genetic Therapy , Immune System , Animals , Humans , Genetic Therapy/methods , Genetic Therapy/trends , Immune System/immunology , Mice
9.
Lab-grown sperm and eggs: 'epigenetic' reset in human cells paves the way.
Ledford, Heidi.
Nature ; 629(8014): 984, 2024 May.
Article in English | MEDLINE | ID: mdl-38778192

Subject(s)
Cell Culture Techniques , Epigenesis, Genetic , Ovum , Spermatozoa , Female , Humans , Male , Epigenesis, Genetic/genetics , Ovum/cytology , Ovum/metabolism , Spermatozoa/metabolism , Spermatozoa/cytology
10.
Audio long read: Why are so many young people getting cancer? What the data say.
Ledford, Heidi; Thompson, Benjamin.
Nature ; 2024 Apr 05.
Article in English | MEDLINE | ID: mdl-38580825
11.
How to make an old immune system young again.
Ledford, Heidi.
Nature ; 2024 Mar 27.
Article in English | MEDLINE | ID: mdl-38538898
12.
Deadly brain cancer shrinks after CAR-T therapy - but for how long is unclear.
Ledford, Heidi.
Nature ; 2024 Mar 13.
Article in English | MEDLINE | ID: mdl-38485827
13.
First US drug approved for a liver disease surging around the world.
Ledford, Heidi.
Nature ; 2024 Mar 15.
Article in English | MEDLINE | ID: mdl-38499800
14.
Why are so many young people getting cancer? What the data say.
Ledford, Heidi.
Nature ; 627(8003): 258-260, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38480960

Subject(s)
Neoplasms , Adolescent , Humans , Neoplasms/epidemiology , Neoplasms/etiology , Incidence , Age of Onset
15.
'Epigenetic' editing cuts cholesterol in mice.
Ledford, Heidi.
Nature ; 627(8002): 14-15, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38418732

Subject(s)
Cholesterol , Epigenesis, Genetic , Epigenomics , Animals , Mice , Epigenomics/methods , Gene Editing , Cholesterol/blood
16.
Smoking scars the immune system for years after quitting.
Ledford, Heidi.
Nature ; 2024 Feb 14.
Article in English | MEDLINE | ID: mdl-38356003
17.
Deepfakes, trolls and cybertroopers: how social media could sway elections in 2024.
Ledford, Heidi.
Nature ; 626(7999): 463-464, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38297054

Subject(s)
Disinformation , Politics , Social Media , Social Sciences , Humans , Social Media/standards , Social Media/statistics & numerical data , Social Media/trends , United States , Harassment, Non-Sexual , Information Dissemination/ethics , Information Dissemination/legislation & jurisprudence , Research Personnel/psychology , Social Sciences/methods , Social Sciences/trends
18.
CRISPR-edited crops break new ground in Africa.
Ledford, Heidi.
Nature ; 626(7998): 245-246, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38278939

Subject(s)
CRISPR-Cas Systems , Crops, Agricultural , Gene Editing , Pest Control, Biological , Plants, Genetically Modified , Africa , CRISPR-Cas Systems/genetics , Crops, Agricultural/genetics , Plants, Genetically Modified/genetics , Pest Control, Biological/methods , Pest Control, Biological/trends
19.
Can foreign coral save a dying reef? Radical idea sparks debate.
Ledford, Heidi.
Nature ; 2024 Jan 15.
Article in English | MEDLINE | ID: mdl-38225417
20.
Long COVID is a double curse in low-income nations - here's why.
Ledford, Heidi.
Nature ; 625(7993): 20-22, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38172361

Subject(s)
Attitude of Health Personnel , Developing Countries , Health Knowledge, Attitudes, Practice , Post-Acute COVID-19 Syndrome , Humans , Developing Countries/economics , Physicians , Post-Acute COVID-19 Syndrome/economics , Post-Acute COVID-19 Syndrome/therapy
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