Bioactive sulfur-containing amides from the leaves of Glycosmis lucida.

Two new sulphur-containing amides, glylucidamides C-D (1-2), along with twelve known analogues (3-14) were isolated and characterised from the leaves of Glycosmis lucida. The chemical structures of 1 and 2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro.

Poly[[tetra-aqua-µ(4)-fumarato-di-µ(3)-fumarato-dineodymium(III)] trihydrate].

The title coordination polymer, {[Nd(2)(C(4)H(2)O(4))(3)(H(2)O)(4)]·3H(2)O}, was synthesized by the reaction of neodymium(III) nitrate hexa-hydrate with fumaric acid in a water-methanol (7:3) solution. The asymmetric unit comprises two Nd(3+) cations, three fumarate dianions (L(2-)), four aqua ligands and three uncoordinated water mol-ecules. The carboxyl-ate groups of the fumarate dianions exhibit different coordination modes. In one fumarate dianion, two carboxyl-ate groups chelate two Nd(3+) cations, while one of the O atoms is coordinated to another Nd(3+) cation. Another fumarate dianion bridges three Nd(3+) cations: one of the carboxyl-ate groups chelates one Nd(3+) cation, while the other carboxyl-ate group bridges two Nd(3+) cations in a monodentate mode. The third fumarate dianion bridges four Nd(3+) cations, where one of the carboxyl-ate groups chelates one Nd(3+) cation and coordinates in a monodentate mode to a second Nd(3+), while the second carboxyl-ate groups bridges two Nd(3+) cations in a monodentate mode and one O atom is coordinated to one Nd(3+) cation. The Nd(3+) cations are in a distorted tricapped-trigonal prismatic environment and coordinated by seven O atoms from the fumarate ligands and two O atoms from water mol-ecules. The Nd(3+) cations are linked by two carboxyl-ate O atoms and two carboxyl-ate groups, generating infinite Nd-O chains to form a three-dimensional framework. There are O-H⋯O and C-H⋯O hydrogen-bonding interactions between the coordin-ated and uncoordinated water mol-ecules and carboxyl-ate O atoms.

Poly[diaquabis-(µ(4)-fumarato-κO:O:O:O)(µ(4)-fumarato-κO:O,O:O:O,O)(µ(2)-fumaric acid-κO:O)dipraseodymium(III)].

The title complex, [Pr(2)(C(4)H(2)O(4))(3)(C(4)H(4)O(4))(H(2)O)(2)](n), was synthesized by reaction of praseodymium(III) nitrate hexa-hydrate with fumaric acid in a water-ethanol (4:1) solution. The asymmetric unit comprises a Pr(3+) cation, one and a half fumarate dianions (L(2-)), one half-mol-ecule of fumaric acid (H(2)L) and one coordinated water mol-ecule. The carboxyl-ate groups of the fumarate dianion and fumaric acid exhibit different coordination modes. In one fumarate dianion, two carboxyl-ate groups are chelating with two Pr(3+) cations, and the other two O atoms each coordinate a Pr(3+) cation. Each O atom of the second fumarate dianion binds to a different Pr(3+) cation. The fumaric acid employs one O atom at each end to bridge two Pr(3+) cations. The Pr(3+) cation is coordinated in a distorted tricapped trigonal-prismatic environment by eight O atoms of fumarate dianion or fumaric acid ligands and one water O atom. The PrO(9) coordination polyhedra are edge-shared through one carboxyl-ate O atom and two carboxyl-ate groups, generating infinite praseodymium-oxygen chains, which are further connected by the ligands into a three-dimensional framework. The crystal structure is stabilized by O-H⋯O hydrogen-bond inter-actions between the coordin-ated water mol-ecule and the carboxyl-ate O atoms.

2-(3,3,4,4-Tetra-fluoro-pyrrolidin-1-yl)aniline.

In the title fluorinated pyrrolidine derivative, C(10)H(10)F(4)N(2), the dihedral angle between the best planes of the benzene and pyrrolidine rings is 62.6 (1)°. The crystal packing features inter-molecular N-H⋯F hydrogen bonds.

3,3,4,4-Tetra-fluoro-1-[2-(3,3,4,4-tetra-fluoro-pyrrolidin-1-yl)phen-yl]pyrrolidine.

The asymmetric unit of the title compound, C(14)H(12)F(8)N(2), contains one tetra-fluoro-pyrrolidine system and one half-mol-ecule of benzene; the latter, together with a second heterocyclic unit, are completed by symmetry, with a twofold crystallographic axis crossing through both the middle of the bond between the C atoms bearing the heterocyclic rings and the opposite C-C bonds of the whole benzene mol-ecule. The pyrrolidine ring shows an envelope conformation with the apex at the N atom. The dihedral angle between the least-squares plane of this ring and the benzene ring is 36.9 (5)°. There are intra-molecular C-H⋯N inter-actions generating S(6) ring motifs. In the crystal structure, the mol-ecules are linked by C-H⋯F inter-actions, forming chains parallel to [010].