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1.

Malo, Courtney; Funk, Michael A; Ash, Caroline; Szuromi, Phil; Grocholski, Brent; Stajic, Jelena; Lopez, Bianca; Ross, Sarah H; Simonti, Corinne N; Jiang, Di; Maroso, Mattia; Kelly, Priscilla N; Lavine, Marc S; Isles, Hannah; Ferrarelli, Leslie K.

Science ; 385(6704): 39-41, 2024 Jul 05.

Article in English | MEDLINE | ID: mdl-38963851

ABSTRACT

Highlights from the Science family of journals.

2.

In Science Journals.

Smith, Keith T; Maroso, Mattia; Osborne, Ian S; Hurtley, Stella M; Szuromi, Phil; Jiang, Di; Malo, Courtney; Ross, Sarah H; Kelly, Priscilla N; Lavine, Marc S; Stern, Peter; Ray, L Bryan; Suleymanov, Yury; Fogg, Christiana; Foley, John F.

Science ; 384(6700): 1078-1080, 2024 Jun 07.

Article in English | MEDLINE | ID: mdl-38843347

ABSTRACT

Highlights from the Science family of journals.

3.

In Science Journals.

Vignieri, Sacha; Lavine, Marc S; Szuromi, Phil; Lopez, Bianca; Jiang, Di; Wong, Wei; Matsiko, Amos; Nusinovich, Yevgeniya; Maroso, Mattia; Smith, Keith T; Olingy, Claire; Malo, Courtney.

Science ; 384(6698): 871-873, 2024 May 24.

Article in English | MEDLINE | ID: mdl-38781360

ABSTRACT

Highlights from the Science family of journals.

4.

In Science Journals.

Smith, Jesse; Lavine, Marc S; Szuromi, Phil; Vignieri, Sacha; Grocholski, Brent; Olingy, Claire; Simonti, Corinne; Yashinski, Melisa; Maroso, Mattia; Nusinovich, Yevgeniya; Uzogara, Ekeoma; Osborne, Ian S; Malo, Courtney; Wong, Wei.

Science ; 384(6699): 972-974, 2024 May 31.

Article in English | MEDLINE | ID: mdl-38815036

ABSTRACT

Highlights from the Science family of journals.

5.

In Science Journals.

Lopez, Bianca; Stajic, Jelena; Jiang, Di; Szuromi, Phil; Aldenderfer, Mark; Grocholski, Brent; Seale, Madeleine; Malo, Courtney; Ross, Sarah H; Ash, Caroline; Hurtley, Stella M; Nusinovich, Yevgeniya; Funk, Michael A; Yeston, Jake S; VanHook, Annalisa M; Isles, Hannah M.

Science ; 384(6691): 43-45, 2024 Apr 05.

Article in English | MEDLINE | ID: mdl-38574135

ABSTRACT

Highlights from the Science family of journals.

6.

In Science Journals.

Matsiko, Amos; Szuromi, Phil; Lopez, Bianca; Jiang, Di; Grocholski, Brent; Yeston, Jake S; Malo, Courtney; Ash, Caroline; Smith, H Jesse; Lavine, Marc S; Maroso, Mattia; Fogg, Christiana N; Wong, Wei.

Science ; 383(6688): 1190-1191, 2024 Mar 15.

Article in English | MEDLINE | ID: mdl-38484047

ABSTRACT

Highlights from the Science family of journals.

7.

In Science Journals.

Walia, Ankit; Lavine, Marc S; Osborne, Ian S; Smith, H Jesse; Suleymanov, Yury; Stern, Peter; Yang, Ming; Malo, Courtney; Alderton, Gemma; Funk, Michael A; Jiang, Di; Ash, Caroline; Grocholski, Brent; Ray, L Bryan; Olingy, Claire; Ferrarelli, Leslie K.

Science ; 383(6690): 1428-1429, 2024 Mar 29.

Article in English | MEDLINE | ID: mdl-38547286

ABSTRACT

Highlights from the Science family of journals.

8.

In Science Journals.

Lopez, Bianca; Kelly, Priscilla N; Yeston, Jake S; Lavine, Marc S; Szuromi, Phil; Vignieri, Sacha; Wong, Wei; Scanlon, Seth Thomas; Stern, Peter; Osborne, Ian S; Grocholski, Brent; Malo, Courtney.

Science ; 383(6679): 159-160, 2024 Jan 12.

Article in English | MEDLINE | ID: mdl-38207042

ABSTRACT

Highlights from the Science family of journals.

9.

In Science Journals.

Grocholski, Brent; Suleymanov, Yury; Lopez, Bianca; Yeston, Jake S; Szuromi, Phil; Kelly, Priscilla N; Foley, John F; Ross, Sarah H; Nusinovich, Yevgeniya; Smith, Keith T; Osborne, Ian S; Isles, Hannah M; Malo, Courtney.

Science ; 383(6680): 269-271, 2024 Jan 19.

Article in English | MEDLINE | ID: mdl-38236979

ABSTRACT

Highlights from the Science family of journals.

10.

In Science Journals.

Jiang, Di; Yeston, Jake S; Isles, Hannah M; Ray, L Bryan; Smith, H Jesse; Grocholski, Brent; Stajic, Jelena; Foley, John F; Simonti, Corinne; Funk, Michael A; Vignieri, Sacha; Smith, Keith T; Scanlon, Seth Thomas; Malo, Courtney.

Science ; 382(6674): 1009-1011, 2023 Dec.

Article in English | MEDLINE | ID: mdl-38033083

ABSTRACT

Highlights from the Science family of journals.

11.

In Science Journals.

Osborne, Ian S; Seale, Madeleine; Foley, John F; Stajic, Jelena; Funk, Michael A; Hurtley, Stella M; Fogg, Christiana N; Malo, Courtney; Lempriere, Sarah A; Vignieri, Sacha; Stern, Peter; Yeston, Jake S; Isles, Hannah M.

Science ; 382(6669): 413-415, 2023 Oct 27.

Article in English | MEDLINE | ID: mdl-37883567

ABSTRACT

Highlights from the Science family of journals.

12.

In Science Journals.

Funk, Michael A; Wong, Wei; Vignieri, Sacha; Stajic, Jelena; Ash, Caroline; Malo, Courtney S; Isles, Hannah M; Hurtley, Stella M; Grocholski, Brent; Stern, Peter; Szuromi, Phil.

Science ; 382(6666): 64-66, 2023 Oct 06.

Article in English | MEDLINE | ID: mdl-37797013

ABSTRACT

Highlights from the Science family of journals.

13.

In Science Journals.

Scanlon, Seth Thomas; Smith, Keith T; Yeston, Jake; Lavine, Marc S; Lopez, Bianca; Malo, Courtney; VanHook, Annalisa M; Uzogara, Ekeoma; Hurtley, Stella M; Kelly, Priscilla N; Grocholski, Brent; Maroso, Mattia; Isles, Hannah M.

Science ; 381(6662): 1061-1063, 2023 Sep 08.

Article in English | MEDLINE | ID: mdl-37676937

ABSTRACT

Highlights from the Science family of journals.

14.

In Science Journals.

Smith, Keith T; Suleymanov, Yury; Szuromi, Phil; Smith, H Jesse; Maroso, Mattia; Olingy, Claire; Malo, Courtney; Funk, Michael A; Vignieri, Sacha; Scanlon, Seth Thomas; Nusinovich, Yevgeniya; Osborne, Ian S; Jiang, Di; Lavine, Marc S; Foley, John F; Lempriere, Sarah A.

Science ; 381(6659): 743-745, 2023 Aug 18.

Article in English | MEDLINE | ID: mdl-37590337

ABSTRACT

Highlights from the Science family of journals.

15.

In Science Journals.

Smith, H Jesse; Jiang, Di; Stajic, Jelena; Yeston, Jake; Fogg, Christiana N; Malo, Courtney S; Ash, Caroline; Simonti, Corinne; Scanlon, Seth Thomas; Szuromi, Phil; Lavine, Marc S; VanHook, Annalisa M; Grocholski, Brent.

Science ; 381(6655): 280-282, 2023 Jul 21.

Article in English | MEDLINE | ID: mdl-37471541

ABSTRACT

Highlights from the Science family of journals.

16.

In Science Journals.

Lopez, Bianca; Lavine, Marc S; Hurtley, Stella M; Yeston, Jake; Jiang, Di; Stajic, Jelena; Ferrarelli, Leslie K; Malo, Courtney S; Seale, Maddy; Szuromi, Phil; Fogg, Christiana N.

Science ; 381(6653): 39-40, 2023 Jul 07.

Article in English | MEDLINE | ID: mdl-37410816

ABSTRACT

Highlights from the Science family of journals.

17.

In Science Journals.

Lopez, Bianca; Vignieri, Sacha; Osborne, Ian S; Yeston, Jake; Jiang, Di; Suleymanov, Yury; Grocholski, Brent; Malo, Courtney S; Kelly, Priscilla N; Scanlon, Seth Thomas; Ray, L Bryan; Smith, Keith T; Ferrarelli, Leslie K; Smith, H Jesse; Olingy, Claire.

Science ; 380(6649): 1024-1025, 2023 Jun 09.

Article in English | MEDLINE | ID: mdl-37289882

ABSTRACT

Highlights from the Science family of journals.

18.

IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium.

Andrews, Caroline; McLean, Mairi H; Hixon, Julie A; Pontejo, Sergio M; Starr, Tregei; Malo, Courtney; Cam, Margaret; Ridnour, Lisa; Hickman, Heather; Steele-Mortimer, Olivia; Wink, David A; Young, Howard A; McVicar, Daniel W; Li, Wenqing; Durum, Scott K.

Front Immunol ; 14: 1021824, 2023.

Article in English | MEDLINE | ID: mdl-37153622

ABSTRACT

Mucosal delivery of IL-27 has been shown to have a therapeutic benefit in murine models of inflammatory bowel disease (IBD). The IL-27 effect was associated with phosphorylated STAT1 (pSTAT1), a product of IL27 receptor signaling, in bowel tissue. To determine whether IL-27 acted directly on colonic epithelium, murine colonoids and primary intact colonic crypts were shown to be unresponsive to IL-27 in vitro and to lack detectable IL-27 receptors. On the other hand, macrophages, which are present in inflamed colon tissue, were responsive to IL-27 in vitro. IL-27 induced pSTAT1 in macrophages, the transcriptome indicated an IFN-like signature, and supernatants induced pSTAT1 in colonoids. IL-27 induced anti-viral activity in macrophages and MHC Class II induction. We conclude that the effects of mucosal delivery of IL-27 in murine IBD are in part based on the known effects of IL27 inducing immunosuppression of T cells mediated by IL-10. We also conclude that IL-27 has potent effects on macrophages in inflamed colon tissue, generating mediators that in turn act on colonic epithelium.

Subject(s)

Inflammatory Bowel Diseases , Interleukin-27 , Mice , Animals , Interleukin-27/therapeutic use , Colon , Inflammatory Bowel Diseases/drug therapy , Macrophages , Epithelium

19.

In Science Journals.

Vignieri, Sacha; Simonti, Corinne; Seale, Maddy; Hurtley, Stella M; Smith, H Jesse; Stajic, Jelena; Malo, Courtney S; Wong, Wei; Szuromi, Phil; Alderton, Gemma; Grocholski, Brent; Lopez, Bianca; Fogg, Christiana N.

Science ; 380(6647): 808-809, 2023 May 26.

Article in English | MEDLINE | ID: mdl-37228196

ABSTRACT

Highlights from the Science family of journals.

20.

In Science Journals.

Vignieri, Sacha; Yeston, Jake; Ray, L Bryan; Cameron, Craig E; Szuromi, Phil; Fogg, Christiana N; Funk, Michael A; Smith, Keith T; Alderton, Gemma; Grocholski, Brent; Kelly, Priscilla N; Simonti, Corinne; Lopez, Bianca; Malo, Courtney S; Ferrarelli, Leslie K.

Science ; 380(6645): 593-595, 2023 May 12.

Article in English | MEDLINE | ID: mdl-37167398

ABSTRACT

Highlights from the Science family of journals.

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