[Autologous bone implant for reconstructive surgery after decompressive craniectomy in children]. / Sposob khraneniya i pogotovki kostnogo autotransplantata dlya zakrytiya defektov svoda cherepa u detei posle dekompressivnoi trepanatsii cherepa.

The concept of post-traumatic skull defect closure is based on restoration of anatomical relationships for the maximum possible recovery of brain function, i.e. it is considered as a stage of surgical rehabilitation. The choice of implants in pediatric patients is limited. In this regard, the «gold standard¼ is still autologous bone implant. MATERIAL AND METHODS: We propose a method for storage and sterilization of autologous bone implant. The last one implies keeping at a temperature of -80 ˚C with sterilization in a vacuum chamber filled with hydrogen peroxide vapors of biocidal plasma medium. Sterilization is provided by 45-minute cycle immediately before surgery. We report skull defect closure using autologous bone implants in 79 patients. Evaluation of effectiveness of storage and sterilization of autologous bone implant included analysis of mechanical properties of bone after sterilization, intra-operative microbiological monitoring, incidence of infections in early postoperative period, follow-up with assessment of resorption. RESULTS: Early infectious complications occurred in 2 patients (2.5%). Complete resorption with redo surgery occurred in 6 (10.1%) cases. Sterilization in low-temperature plasma of hydrogen peroxide changes mechanical properties of the bone, increases durability under compressive stresses and decreases durability under tensile conditions. This does not affect functional tasks of autologous bone. The proposed method of storage and sterilization is accompanied by low risk of infections and resorption. Storage of autologous bone implant at a temperature of -80 ˚C with subsequent sterilization in low-temperature plasma of hydrogen peroxide can be considered as a safe and effective method for skull defect closure in children after decompressive surgery.

[Permanent central diabetes insipidus after traumatic brain injury. Case report and literature review]. / Razvitie postoyannogo tsentral'nogo nesakharnogo diabeta posle travmaticheskogo povrezhdeniya golovnogo mozga. Klinicheskii sluchai i obzor literatury.

The authors report permanent central diabetes insipidus (CDI) in a patient after severe traumatic brain injury (TBI) in traffic accident. A 16-year-old boy entered to a medical facility in coma (GCS score 6) with the following diagnosis: acute TBI, severe cerebral contusion, subarachnoid hemorrhage, depressed comminuted cranial vault fracture, basilar skull fracture, visceral contusion. CDI was diagnosed in 3 days after injury considering polyuria and hypernatremia (155 mmol/l). Desmopressin therapy was initiated through a feeding tube. Thirst appeared when a patient came out of the coma after 21 days despite ongoing desmopressin therapy. Considering persistent thirst and polyuria, we continued desmopressin therapy in a spray form. Under this therapy, polyuria reduced to 3-3.5 liters per a day. Symptoms of CDI persisted in long-term period (2 years after TBI) while function of adenohypophysis was intact. This case demonstrates a rare development of permanent diabetes insipidus after TBI. CDI manifested only as polyuria and hypernatremia in coma. Thirst joined after recovery of consciousness. Probable causes of CDI were damage to neurohypophysis and partially injury of pituitary stalk because of extended basilar skull fracture and/or irreversible secondary lesion of hypothalamus following diffuse axonal damage after TBI.

Infrascanner in the diagnosis of intracranial lesions in children with traumatic brain injuries.

BACKGROUND: The number of traumatic injuries among children is increasing. However, so-called mild TBI might result in unfavourable outcomes. Early diagnosis of intracranial haematomas prior to development of serious complications may be a decisive factor for a favourable outcome. InfraScan company developed and brought to the market the Infrascanner model 1000, which is a portable detector of blood collections that operates in the near infrared (NIR) band. OBJECTIVE: To estimate the efficiency of the Infrascanner model 1000 for detection of intracranial haematomas among children with mild TBI. MATERIALS AND METHODS: Ninety-five patients with mild TBI were examined. An indication for cerebral CT after mild TBI was the presence of risk factors of intracranial lesions. The Infrascanner was used by a neurosurgeon during primary examination. CT was performed in 43 patients (45%), while 52 patients (55%) with a low risk of intracranial lesions were under observation. RESULTS: The results of examination of patients using CT and infrared scanning coincided in 39 cases and intracranial haematomas were detected in eight patients. False-positive results were obtained in three cases. The sensitivity of the procedure used in this group of patients with a medium and high risk of development of intracranial haemorrhages was 1.00 (0.66; 1.00). The specificity was 0.91 (0.81; 1.00)--the proportions and a 95% CI. The false-positive risk is 0.27 (0.00; 0.58). During infrared scanning in patients with low risk of intracranial lesions, false-positive results were obtained in four cases and false-negative results were absent. CONCLUSION: Infra-scanning might be viewed as a screening technique for intracranial haemorrhages in ambulances and outpatient trauma centres in order to decide on hospitalization, CT scanning and referral to a neurosurgeon. Infra-scanning combined with evaluation of risk factors of intracranial damage might reduce the number of unnecessary radiological examinations.