ABSTRACT
OBJECTIVE AND DESIGN: The aim of this study was to investigate the effects of ethanol exposure on epigenetic markers in bone marrow (BM) and their impact on inflammatory response during Aspergillus fumigatus infection. RESULTS: Chronic ethanol exposure decreased H3K27me3 enrichment in the Il6 promoter region while increased H3K4me3 enrichment in Tnf. Chimeric mice were generated by transplanting BM from mice exposed to ethanol or water. Infection of ethanol-chimeric mice culminated in higher clinical scores, although there was no effect on mortality. However, previous chronic exposure to ethanol affects persistently the inflammatory response in lung tissue, demonstrated by increased lung damage, neutrophil accumulation and IL-6, TNF and CXCL2 production in ethanol-chimeric mice, resulting in a decreased neutrophil infiltration into the alveolar space. Neutrophil killing and phagocytosis were also significantly lower. Moreover, BM derived macrophages (BMDM) from ethanol-chimeric mice stimulated with A. fumigatus conidia exhibited higher levels of TNF, CXCL2 and IL-6 release and a higher killing activity. The Il6 promoter of BMDM from ethanol-chimeric mice exhibited a reduction in H3K27me3 enrichment, a finding also observed in BM donors exposed to ethanol. CONCLUSIONS: These evidences demonstrate that prior chronic alcohol exposure of bone-marrow modify immune effector cells functions impairing the inflammatory response during A. fumigatus infection. These findings highlight the persistent impact of chronic ethanol exposure on infectious disease outcomes.
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Introduction: Complex regional pain syndrome type I (CRPS-I) is a debilitating neuropathic painful condition associated with allodynia, hyperalgesia, sudomotor and/or vasomotor dysfunctions, turning investigation of its pathophysiology and new therapeutic strategies into an essential topic. We aim to investigate the impact of ischemia/reperfusion injury on the immunocontent of CB1 and CB2 cannabinoid receptor isoforms in the paws of mice submitted to a chronic postischemia pain (CPIP) model and the effects of local administration of cannabidiol (CBD) on mechanical hyperalgesia. Methods: Female Swiss mice, 30-35 g, were submitted to the CPIP model on the right hind paw. Skin and muscle samples were removed at different periods for western blot analysis. Results: No changes in the immunocontent of CB1 and CB2 receptors in paw muscle tissues after ischemia-reperfusion were observed. CBD promoted an antihyperalgesic effect in both phases. AM281 reversed the effect of CBD, whereas ruthenium red abolished the late phase. Conclusion: Our results point to the possible beneficial effects of local administration of CBD in modulating CRPS-I in humans. As possible targets for CBD antihyperalgesia in this model, the contribution of cannabinoid receptor CB1, in addition to TRPM8 is suggested.
ABSTRACT
Nephrotic syndrome (NS) is associated with kidney dysfunction and is an important cause of morbidity and mortality in industrialized countries. Here, we evaluated the effects of the phosphodiesterase-4 (PDE-4) inhibitors rolipram and roflumilast on a doxorubicin-induced NS model. Early-stage rolipram treatment preserved glomerular filtration barrier function, as indicated by reduced serum protein and albumin loss and the prevention of hypercholesterolemia. These effects were associated with reduced glomerular and tubular lesions and abrogated renal cell apoptosis. In addition, rolipram treatment reduced inflammation, which was characterized by a decrease in macrophage accumulation and reduced levels of CCL2 and TNF in the kidneys. Rolipram also reduced renal fibrosis, which was associated with decreased α-smooth muscle actin (α-SMA) area and increased metalloproteinase 9 (MMP9) activity in renal tissue. Late-stage rolipram or roflumilast treatment preserved glomerular filtration barrier function, as characterized by reduced serum albumin loss, decreased proteinuria, and the prevention of hypercholesterolemia. Importantly, only roflumilast treatment was associated with a reduction in glomerular and tubular lesions at this time point. In addition, both rolipram and roflumilast reduced renal tissue fibrosis and MMP9 activity in renal tissue.
Subject(s)
Hypercholesterolemia , Kidney Diseases , Phosphodiesterase 4 Inhibitors , Mice , Animals , Phosphodiesterase 4 Inhibitors/therapeutic use , Phosphodiesterase 4 Inhibitors/pharmacology , Rolipram/pharmacology , Rolipram/therapeutic use , Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism , Matrix Metalloproteinase 9 , Kidney/metabolism , Kidney Diseases/chemically induced , Kidney Diseases/drug therapy , Disease Models, Animal , FibrosisABSTRACT
Inflammation resolution is an active process that involves cellular events such as apoptosis and efferocytosis, which are key steps in the restoration of tissue homeostasis. Hepatocyte growth factor (HGF) is a growth factor mostly produced by mesenchymal-origin cells and has been described to act via MET receptor tyrosine kinase. The HGF/MET axis is essential for determining the progression and severity of inflammatory and immune-mediated disorders. Here, we investigated the effect of blocking the HGF/MET signalling pathway by PF-04217903 on the resolution of established models of neutrophilic inflammation. In a self-resolving model of gout induced by MSU crystals, HGF expression on periarticular tissue peaked at 12 h, the same time point that neutrophils reach their maximal accumulation in the joints. The HGF/MET axis was activated in this model, as demonstrated by increased levels of MET phosphorylation in neutrophils (Ly6G+ cells). In addition, the number of neutrophils was reduced in the knee exudate after PF-04217903 treatment, an effect accompanied by increased neutrophil apoptosis and efferocytosis and enhanced expression of Annexin A1, a key molecule for inflammation resolution. Reduced MPO activity, IL-1ß and CXCL1 levels were also observed in periarticular tissue. Importantly, PF-04217903 reduced the histopathological score and hypernociceptive response. Similar findings were obtained in LPS-induced neutrophilic pleurisy. In human neutrophils, the combined use of LPS and HGF increased MET phosphorylation and provided a prosurvival signal, whereas blocking MET with PF-04217903 induced caspase-dependent neutrophil apoptosis. Taken together, these data demonstrate that blocking HGF/MET signalling may be a potential therapeutic strategy for inducing the resolution of neutrophilic inflammatory responses.
Subject(s)
Hepatocyte Growth Factor , Neutrophils , Humans , Hepatocyte Growth Factor/metabolism , Hepatocyte Growth Factor/pharmacology , Hepatocyte Growth Factor/therapeutic use , Lipopolysaccharides/pharmacology , Inflammation/metabolism , Apoptosis , Proto-Oncogene Proteins c-met/metabolism , HomeostasisABSTRACT
OBJECTIVES: to evaluate the quality of Primary Health Care attributes according to the characterization and perspective of women of reproductive age. METHODS: descriptive, quantitative, cross-sectional study, with 397 women of reproductive age from six municipalities in the 16th Health Region of the state of Paraná, with variables for sociodemographic characterization and the Primary Care Assessment Tool (PCATool). RESULTS: mean age, 30.43 years old, most were married, 70.2% worked outside the home and 55.5% had completed high school. The highest average score of the eight domains evaluated was "Family Guidance" and "Coordination - Integration of Care", with averages of 5.86 and 4.89. Domains "Integrality - Services Provided" and "Community Orientation" had lower averages (3.32 and 3.76). CONCLUSIONS: the study allowed tracing the characterization of the participants and identifying that the attributes of Primary Care are unsatisfactory, making it necessary to expand access to the services offered and to qualify the comprehensive care for women's health.
Subject(s)
Primary Health Care , Reproduction , Adult , Brazil , Comprehensive Health Care , Cross-Sectional Studies , Female , HumansABSTRACT
Asthma is a chronic and heterogeneous disease of the airways that begins in childhood and persists, in many cases, into adulthood. The disease is the result of environmental, epigenetic and genetic interactions. This work aims to review the polymorphisms described in the literature in the IL-4 gene associated with susceptibility or protection to the development of asthma. This is a systematic literature review, carried out in PubMed, MEDLINE and Science Direct databases in the time frame from 2000 to July 2021, revealing the following key points: IL-4, Polymorphisms and Asthma. The search resulted in 29 articles, all in English. Despite some divergent studies, the SNP rs2243250, which was the most studied in populations from different countries, was also the one that found the most correlations of susceptibility with the disease. It is concluded that although there is controversial data on IL-4 SNPs related to the disease, the association of pangenomic studies has brought a list of genes and their variations associated with the risk of developing asthma, such as the rs2243250 SNP that was well related in populations of several countries analyzed. (AU)
A asma é uma doença crônica e heterogênea das vias aéreas que tem início na infância e persiste em muitos casos até a vida adulta. A doença é resultado de interações ambientais, epigenéticas e genéticas. Este trabalho tem como objetivo revisar sobre os polimorfismos descritos na literatura no gene IL-4 associados à susceptibilidade ou proteção ao desenvolvimento da asma. Trata-se de uma revisão sistemática da literatura, feita nos bancos de dados PubMed, MEDLINE e Science Direct no corte temporal de 2000 a julho de 2021, ressaltando os seguintes pontos-chave: IL-4, Polimorfismos e Asma. A pesquisa resultou em 29 artigos, sendo em sua totalidade em língua inglesa. Apesar de alguns estudos divergentes, o SNP rs2243250, que foi o mais estudado em populações de diversos países, também foi o que mais encontrou correlações de susceptibilidade com a doença. Conclui-se que, apesar de haver dados controversos sobre os SNPs de IL-4 relacionados à doença, a associação dos estudos pangenômicos tem trazido uma lista de genes e variações deles associados com o risco de desenvolver a asma, como o SNP rs2243250 que foi bem relacionado em populações de vários países analisados (AU).
Subject(s)
Polymorphism, Genetic , Asthma , Interleukin-4 , Systematic ReviewABSTRACT
ABSTRACT Objectives: to evaluate the quality of Primary Health Care attributes according to the characterization and perspective of women of reproductive age. Methods: descriptive, quantitative, cross-sectional study, with 397 women of reproductive age from six municipalities in the 16th Health Region of the state of Paraná, with variables for sociodemographic characterization and the Primary Care Assessment Tool (PCATool). Results: mean age, 30.43 years old, most were married, 70.2% worked outside the home and 55.5% had completed high school. The highest average score of the eight domains evaluated was "Family Guidance" and "Coordination - Integration of Care", with averages of 5.86 and 4.89. Domains "Integrality - Services Provided" and "Community Orientation" had lower averages (3.32 and 3.76). Conclusions: the study allowed tracing the characterization of the participants and identifying that the attributes of Primary Care are unsatisfactory, making it necessary to expand access to the services offered and to qualify the comprehensive care for women's health.
RESUMEN Objetivos: evaluar la calidad de atributos de la Atención Primaria de Salud conforme la caracterización y perspectiva de mujeres en edad fértil. Métodos: investigación descriptiva, cuantitativa, de delineamento transversal, con 397 mujeres en edad fértil de seis municipios de la 16ª Regional de Salud del estado de Paraná, con variables para caracterización sociodemográfica y el Instrumento Primary Care Assessment Tool (PCATool). Resultados: mediana de edad, 30,43 años, mayoría era casada, 70,2% trabajaban fuera y 55,5% hicieron bachillerato completo. El mayor escore mediano de los ocho dominios evaluados fue "Orientación Familiar" y "Coordinación - Integración de Cuidados", con medianas 5,86 y 4,89. Dominios "Integralidad - Servicios Prestados" y "Orientación Comunitaria" tuvieron menores medianas (3,32 y 3,76). Conclusiones: el estudio permitió trazar la caracterización de las participantes e identificar que los atributos de Atención Primaria están insatisfactorios, siendo necesario ampliar el acceso a servicios ofertados y calificar el cuidado integral de salud para mujer.
RESUMO Objetivos: avaliar a qualidade dos atributos da Atenção Primária à Saúde de acordo com a caracterização e perspectiva de mulheres em idade reprodutiva. Métodos: pesquisa descritiva, quantitativa, de delineamento transversal, com 397 mulheres em idade reprodutiva de seis municípios da 16ª Regional de Saúde do estado do Paraná, com variáveis para caracterização sociodemográfica e o Instrumento Primary Care Assessment Tool (PCATool). Resultados: média da idade, 30,43 anos, maioria era casada, 70,2% trabalhavam fora e 55,5% tinham ensino médio completo. O maior escore médio dos oito domínios avaliados foi "Orientação Familiar" e "Coordenação - Integração de Cuidados", com médias 5,86 e 4,89. Domínios "Integralidade - Serviços Prestados" e "Orientação Comunitária" tiveram menores médias (3,32 e 3,76). Conclusões: o estudo permitiu traçar a caracterização das participantes e identificar que os atributos da Atenção Primária estão insatisfatórios, sendo necessário ampliar o acesso aos serviços ofertados e qualificar o cuidado integral à saúde da mulher.
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OBJECTIVE: To analyze factors and behaviors associated with the prevalence of abortion in female partners of prisoners. METHODS: Descriptive, cross-sectional study with a quantitative approach carried out with 349 women of inmates in three penitentiaries in the State of Paraná. For data collection, it was used validated instrument BSSB - Brazilian Study on Sexual Behavior. Descriptive analyzes were processed, and through the Chi-square test, the occurrence of abortion and the researched variables were associated. RESULTS: (38.3%) of the women reported abortion throughout their lives, there was an association between women under the age of 30 (p=<0.001), who reported smoking (p=<0.044), not using condoms (p=<0.001), who suffered sexual violence (p = <0.050) and who reported a diagnosis of Sexually Transmitted Infections (p=<0.001). CONCLUSION: The present study showed associated factors for high prevalence of abortion in women partners of inmates. Abortion is considered an important public health problem and needs to be treated with priority by public health policies in different population groups.
Subject(s)
Sexually Transmitted Diseases , Condoms , Cross-Sectional Studies , Female , Humans , Prevalence , Sexual Behavior , Sexual Partners , Sexually Transmitted Diseases/epidemiologyABSTRACT
Biochanin A (BCA) is a natural organic compound of the class of phytochemicals known as flavonoids and isoflavone subclass predominantly found in red clover (Trifolium pratense). It has anti-inflammatory activity and some pro-resolving actions, such as neutrophil apoptosis. However, the effect of BCA in the resolution of inflammation is still poorly understood. In this study, we investigated the effects of BCA on the neutrophilic inflammatory response and its resolution in a model of antigen-induced arthritis. Male wild-type BALB/c mice were treated with BCA at the peak of the inflammatory process (12 h). BCA decreased the accumulation of migrated neutrophils, and this effect was associated with reduction of myeloperoxidase activity, IL-1ß and CXCL1 levels, and the histological score in periarticular tissues. Joint dysfunction, as seen by mechanical hypernociception, was improved by treatment with BCA. The resolution interval (Ri) was also quantified, defining profiles of acute inflammatory parameters that include the amplitude and duration of the inflammatory response monitored by the neutrophil infiltration. BCA treatment shortened Ri from â¼23 h observed in vehicle-treated mice to â¼5.5 h, associated with an increase in apoptotic events and efferocytosis, both key steps for the resolution of inflammation. These effects of BCA were prevented by H89, an inhibitor of protein kinase A (PKA) and G15, a selective G protein-coupled receptor 30 (GPR30) antagonist. In line with the in vivo data, BCA also increased the efferocytic ability of murine bone marrow-derived macrophages. Collectively, these data indicate for the first time that BCA resolves neutrophilic inflammation acting in key steps of the resolution of inflammation, requiring activation of GPR30 and via stimulation of cAMP-dependent signaling.
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Resumo Introdução Os Agentes Comunitários de Saúde são uma categoria profissional no Brasil que se encontram contato direto e diário com os usuários na comunidade e possuem maior probabilidade de se deparar com situações de emergência ou primeiros socorros. Objetivo Avaliar o conhecimento e autoconfiança de Agentes Comunitários de Saúde sobre Primeiros Socorros e Parada cardiopulmonar. Materiais e Método Estudo descritivo e quantitativo, realizado de junho a outubro de 2018, em 22 Centros de Saúde da Família de município do Ceará, Brasil, com 186 Agentes Comunitários de Saúde, divididos em dois grupos: aqueles já tinham treinamento sobre a temática e os que não possuíam treinamento. Na coleta de dados foi aplicado questionário com: 1) caracterização da amostra; 2) Questões sobre Parada Cardiopulmonar; 3) Questões sobre primeiros socorros; 4) Escala de autoconfiança. Resultados Houve diferença significante entre os grupos nas questões de conhecimento em quatro itens, nas questões sobre definição de PCR, verificação da responsividade de uma vítima desacordada, sequência para o posicionamento das mãos e braços na ressuscitação cardiopulmonar (RCP) e momento de troca dos socorristas. Nos primeiros socorros, houve diferença estatisticamente significante em quatro itens, nas questões de primeira conduta no caso de precisar atender uma vítima em situação de urgência, cuidados durante uma crise de convulsão, condutas com vítimas de afogamento e cuidados com bebê engasgado. Ambos os grupos apresentaram autoconfiança baixa para intervir em situações de emergências cardíacas, neurológicas e respiratórias. Conclusão Os achados da pesquisa apontam déficit de conhecimento dos agentes comunitários de saúde para atuar frente a parada Cardiopulmonar e em situações de primeiros socorros, associado à baixa autoconfiança para intervir em situações de emergências.
Abscratc Introduction Community health workers are considered a professional health category in Brazil who are in direct daily contact with community users and, therefore, more likely to face emergency or first aid situations. Objective To assess the level of knowledge and confidence of community health workers on first aid and cardiopulmonary resuscitation. Materials and Methods A descriptive quantitative study was conducted between June and October 2018 in 22 Family Health Centers in a city in Ceará, Brazil with 186 community agents grouped as follows: a group that has already received training on these matters and another group that has not had such training. For data collection, a questionnaire containing the following items was administered: 1) sample characterization; 2) questions on cardiopulmonary resuscitation; 4) questions on first aid; 4) confidence scale. Results A significant difference among both groups was found in questions related to the knowledge of the four items, especially for explaining CPR, checking for responsiveness of an unconscious person, the sequence for placing hands and arms in cardiopulmonary resuscitation (CPR) and rotating resuscitators. Regarding first aid, a statistically significant difference was also found in four items related to first aid questions when attending a victim in an emergency such as convulsions, drowning and choking in children. Both groups showed low confidence to intervene in cardiac, neurological and respiratory emergencies. Conclusions Research results indicate that there is a lack of knowledge among community health workers to respond effectively to situations involving cardiopulmonary resuscitation and first aid, which is also associated with low confidence to perform interventions in emergencies.
Resumen Introducción Los agentes comunitarios de salud constituyen una categoría sanitaria profesional en Brasil que está en contacto directo a diario con los usuarios de la comunidad, por lo que tiene más probabilidades de enfrentarse a situaciones de emergencia o primeros auxilios. Objetivo Evaluar los conocimientos y el grado de confianza de los agentes comunitarios de salud en materia de primeros auxilios y reanimación cardiopulmonar. Materiales y Métodos Se realizó un estudio cuantitativo descriptivo entre junio y octubre de 2018 en 22 Centros de Salud Familiar de una ciudad del estado de Ceará, Brasil con 186 agentes comunitarios, que luego fueron agrupados así: un grupo que ya contaba con formación sobre estos temas y otro grupo que no contaba con dicha formación. Para la recolección de datos, se administró un cuestionario que contenía los siguientes ítems: 1) caracterización de la muestra; 2) preguntas sobre reanimación cardiopulmonar; 3) preguntas sobre primeros auxilios; 4) escala del grado de confianza. Resultados Se presentó una diferencia significativa entre los grupos en cuanto a las preguntas relacionadas con los conocimientos de los cuatro ítems, especialmente en cuanto a la definición de RCP, la comprobación de la capacidad de respuesta de una víctima en estado de inconciencia, la secuencia para la colocación de manos y brazos en la reanimación cardiopulmonar (RCP) y los turnos para cambiar los reanimadores. En cuanto a primeros auxilios, también se presentó una diferencia estadísticamente significativa en cuatro ítems relacionados con preguntas de primeros auxilios en caso de necesitar atender una víctima en una situación de emergencia, durante una crisis convulsiva o víctimas de ahogamiento y atragantamiento en bebés. Ambos grupos presentaron un bajo grado de confianza para realizar intervenciones en situaciones de emergencias cardíacas, neurológicas y respiratorias. Conclusiones Los resultados de la investigación apuntan a un déficit de conocimiento por parte de los agentes comunitarios de salud para actuar frente situaciones que requieren reanimación cardiopulmonar y primeros auxilios, lo cual está también asociado a un bajo grado de confianza para realizar intervenciones en situaciones de emergencia.
Subject(s)
Community Health Workers , Knowledge , Heart ArrestABSTRACT
Introdução: Os Agentes Comunitários de Saúde são uma categoria profissional no Brasil que se encontram contato direto e diário com os usuários na comunidade e possuem maior probabilidade de se deparar com situações de emergência ou primeiros socorros. Objetivo: Avaliar o conhecimento e autoconfiança de Agentes Comunitários de Saúde so-bre Primeiros Socorros e Parada cardiopulmonar. Materiais e Método:Estudo descritivo e quantitativo, realizado de junho a outubro de 2018, em 22 Centros de Saúde da Família de município do Ceará, Brasil, com 186 Agentes Comunitários de Saúde, divididos em dois grupos: aqueles já tinham treinamento sobre a temática e os que não possuíam treina-mento. Na coleta de dados foi aplicado questionário com: 1) caracteri-zação da amostra; 2) Questões sobre Parada Cardiopulmonar; 3) Ques-tões sobre primeiros socorros; 4) Escala de autoconfiança. Resultados:Houve diferença significante entre os grupos nas questões de conhe-cimento em quatro itens, nas questões sobre definição de PCR, verifi-cação da responsividade de uma vítima desacordada, sequência para o posicionamento das mãos e braços na ressuscitação cardiopulmonar (RCP) e momento de troca dos socorristas. Nos primeiros socorros, hou-ve diferença estatisticamente significante em quatro itens, nas questões de primeira conduta no caso de precisar atender uma vítima em situa-ção de urgência, cuidados durante uma crise de convulsão, condutas com vítimas de afogamento e cuidados com bebê engasgado. Ambos os grupos apresentaram autoconfiança baixa para intervir em situações de emergências cardíacas, neurológicas e respiratórias. Conclusão: Os achados da pesquisa apontam déficit de conhecimento dos agentes co-munitários de saúde para atuar frente a parada Cardiopulmonar e em situações de primeiros socorros, associado à baixa autoconfiança para intervir em situações de emergências.
Introduction: Community health workers are considered a professional health category in Brazil who are in direct daily contact with community users and, therefore, more likely to face emergency or first aid situations. Objective: To assess the level of knowledge and confidence of community health workers on first aid and cardiopulmonary resuscitation. Materials and Methods: A descriptive quantitative study was conducted between June and October 2018 in 22 Family Health Centers in a city in Ceará, Brazil with 186 community agents grouped as follows: a group that has already received training on these matters and another group that has not had such training. For data collection, a questionnaire containing the following items was administered: 1) sample characterization; 2) questions on cardiopulmonary resuscitation; 4) questions on first aid; 4) confidence scale. Results: A significant difference among both groups was found in questions related to the knowledge of the four items, especially for explaining CPR, checking for responsiveness of an unconscious person, the sequence for placing hands and arms in cardiopulmonary resuscitation (CPR) and rotating resuscitators. Regarding first aid, a statistically significant difference was also found in four items related to first aid questions when attending a victim in an emergency such as convulsions, drowning and choking in children. Both groups showed low confidence to intervene in cardiac, neurological and respiratory emergencies. Conclusions: Research results indicate that there is a lack of knowledge among community health workers to respond effectively to situations involving cardiopulmonary resuscitation and first aid, which is also associated with low confidence to perform interventions in emergencies.
Introducción: Los agentes comunitarios de salud constituyen una categoría sanitaria profesional en Brasil que está en contacto directo a diario con los usuarios de la comunidad, por lo que tiene más probabilidades de enfrentarse a situaciones de emergencia o primeros auxilios. Objetivo: Evaluar los conocimientos y el grado de confianza de los agentes comunitarios de salud en materia de primeros auxilios y reanimación cardiopulmonar. Materiales y Métodos: Se realizó un estudio cuantitativo descriptivo entre junio y octubre de 2018 en 22 Centros de Salud Familiar de una ciudad del estado de Ceará, Brasil con 186 agentes comunitarios, que luego fueron agrupados así: un grupo que ya contaba con formación sobre estos temas y otro grupo que no contaba con dicha formación. Para la recolección de datos, se administró un cuestionario que contenía los siguientes ítems: 1) caracterización de la muestra; 2) preguntas sobre reanimación cardiopulmonar; 3) preguntas sobre primeros auxilios; 4) escala del grado de confianza. Resultados: Se presentó una diferencia significativa entre los grupos en cuanto a las preguntas relacionadas con los conocimientos de los cuatro ítems, especialmente en cuanto a la definición de RCP, la comprobación de la capacidad de respuesta de una víctima en estado de inconciencia, la secuencia para la colocación de manos y brazos en la reanimación cardiopulmonar (RCP) y los turnos para cambiar los reanimadores. En cuanto a primeros auxilios, también se presentó una diferencia estadísticamente significativa en cuatro ítems relacionados con preguntas de primeros auxilios en caso de necesitar atender una víctima en una situación de emergencia, durante una crisis convulsiva o víctimas de ahogamiento y atragantamiento en bebés. Ambos grupos presentaron un bajo grado de confianza para realizar intervenciones en situaciones de emergencias cardíacas, neurológicas y respiratorias. Conclusiones: Los resultados de la investigación apuntan a un déficit de conocimiento por parte de los agentes comunitarios de salud para actuar frente situaciones que requieren reanimación cardiopulmonar y primeros auxilios, lo cual está también asociado a un bajo grado de confianza para realizar intervenciones en situaciones de emergencia
Subject(s)
Cardiopulmonary Resuscitation , Community Health Workers , Knowledge , Heart ArrestABSTRACT
Objetivou-se analisar a incidência de sífilis congênita e os fatores associados à transmissão vertical na 16ª Regional de Saúde do Estado do Paraná. Trata-se de uma pesquisa transversal realizada mediante pareamento das notificações nos bancos de dados do Sinan, Sinasc e SIM entre 2012 e 2017. A análise estatística foi calculada através das frequências absolutas e relativas e da aplicação do teste Qui-quadrado ,com grau de confiança de 95%. A incidência de sífilis congênita passou de 0.41/1.000 nascidos vivos para 6.07/1.000 e esteve associada ao diagnóstico realizado no terceiro trimestre de gestação (OR= 2,051), teste treponêmico não realizado ou ignorado no diagnóstico da sífilis gestacional (OD=2,339) e titulações do teste não treponêmico entre 1:8 e 1:16 (OD= 2,386) e entre 1:32 a 1:64 (OD= 2,353). A variável neonatal associada à sífilis foi anomalia congênita (p=0,037). Concluiu-se que é necessário o aprimoramento da assistência quanto ao diagnóstico precoce, tratamento correto e seguimento.
The objective was to analyze the incidence of congenital syphilis and the factors associated with vertical transmission in the 16th Regional Health System of the State of Paraná. This is a cross-sectional survey conducted by pairing the notifications in the Sinan, Sinasc and SIM databases between 2012 and 2017. The statistical analysis was calculated using absolute and relative frequencies and the Chi-square test, with a 95% confidence level. The incidence of congenital syphilis rose from 0.41/1,000 live births to 6.07/1. 000 and was associated with the diagnosis made in the third trimester of pregnancy (OR= 2.051), treponemic test not performed or ignored in the diagnosis of gestational syphilis (OD=2.339) and titrations of the non treponemic test between 1:8 and 1:16 (OD= 2.386) and between 1:32 and 1:64 (OD= 2.353). The neonatal variable associated with syphilis was a congenital anomaly (p=0.037). It was concluded that it is necessary to improve the assistance regarding early diagnosis, correct treatment and follow-up.
ABSTRACT
This cross-sectional study aims to investigate the epidemiology and spatial distribution of hemotropic Mycoplasma spp. and Mycoplasma haemocanis in dogs from Rio de Janeiro, Brazil. Blood samples were collected at random from 437 household dogs. An epidemiological questionnaire was completed concerning the host characteristics as well as the environments in which they lived. A positivity frequency of 17.84% (78/437) was found for Mycoplasma spp. and 2% (9/437) for M. haemocanis in Rio de Janeiro, Brazil, through molecular detection based on the 16S rRNA sequence. According to the present study, dogs that live in households with the presence of rodents (odds ratio [OR] = 9.93; p-value = 0.02; confidence interval [CI]: 1.34-73.66) and wild animals (OR = 1.91; p-value = 0.03; CI: 1.06-3.42) are more likely to be infected with Mycoplasma spp.. Also, dogs with tick infestation (OR = 6.47; p-value = 0.007; CI: 1.63-25.60) have more chances to become infected with M. haemocanis. The spatial analysis disclosed a positive correlation between the Mycoplasma presence and tick infestation (global Moran index = 0.82; pseudo-p-value =0.001). The epidemiological findings support the hypothesis of Rhipicephalus sanguineus s.l. as the vector of M. haemocanis in the studied region and provide insightful information to prevent the Mycoplasma spp. infection in dogs from Rio de Janeiro.
Subject(s)
Dog Diseases/microbiology , Dog Diseases/parasitology , Molecular Epidemiology , Mycoplasma Infections/veterinary , Mycoplasma/isolation & purification , Rhipicephalus sanguineus/microbiology , Tick Infestations/microbiology , Animals , Brazil , Cross-Sectional Studies , Disease Vectors , Dogs , GeographyABSTRACT
Resumo Objetivo: Identificar, na literatura científica, a relação da obesidade como fator de risco agravante para a morbidade por COVID-19. Métodos: Trata-se de um estudo bibliográfico, tipo revisão integrativa de literatura, nos idiomas português, inglês e espanhol, por meio da estratégia PICo, em cinco bases de dados,PubMed, Scopus, Web of Science, Embasee BVS, realizada de maio a junho de 2020. Os critérios de inclusão adotados foram: artigos primários realizados com adultos; disponíveis na íntegra; publicados durante o período de 2019 a 2020; nos idiomas português, inglês e espanhol. Os critérios de exclusão foram: relato de casos; casos clínicos; dissertações; teses; os já selecionados na busca em outra base de dados e que não respondessem à questão da pesquisa. Resultados: A seleção resultou em noveestudos, sendo que quatro estudos - 44,4% (E3, E5, E6 e E7) - apresentaram a prevalência de obesidade em adultos hospitalizados por COVID-19, dois estudos - 22,2% (E6, E9) - associaram a obesidade ao desenvolvimento da COVID-19 grave, três estudos - 33,3% (E1, E4 e E7) - associaram a obesidade à necessidade de ventilação mecânica e três estudos - 33,3% (E2, E4 e E8) - associaram a obesidade à mortalidade por COVID-19. Conclusão: A obesidade trata-se de uma doença crônica não transmissível, sendo um fator de risco considerado importante para o agravamento da doença COVID-19, no entanto, é passível de prevenção, pois hábitos saudáveis de vida podem reduzir o quadro grave de infecção por COVID-19.
Resumen Objetivo: Identificar en la literatura científica la relación de la obesidad como factor de riesgo agravante para la morbilidad por COVID-19. Métodos: Se trata de un estudio bibliográfico, tipo revisión integradora de literatura, en idioma portugués, inglés y español, por medio de la estrategia PICO, en cinco bases de datos: PubMed, Scopus, Web of Science, Embase y BVS, realizada de mayo a junio de 2020. Los criterios de inclusión adoptados fueron: artículos primarios realizados con adultos, con texto completo disponible, publicados durante el período de 2019 a 2020, en idioma portugués, inglés y español. Los criterios de exclusión fueron: relato de casos, casos clínicos, tesis de maestría y doctorado, los artículos ya seleccionados en la búsqueda en otra base de datos y los que no respondieran la pregunta de investigación. Resultados: La selección tuvo como resultado nueve estudios, de los cuales cuatro — 44,4% (E3, E5, E6 y E7) — presentaron prevalencia de obesidad en adultos hospitalizados por COVID-19; en dos estudios — 22,2% (E6, E9) — se relacionó la obesidad con el desarrollo de COVID-19 grave; en tres estudios — 33,3% (E1, E4 y E7) — se relacionó la obesidad con la necesidad de ventilación mecánica; y en tres estudios — 33,3% (E2, E4 y E8) — se relacionó la obesidad con la mortalidad por COVID-19. Conclusión: La obesidad se trata de una enfermedad crónica no transmisible y es considerada un factor de riesgo importante para el agravamiento de la enfermedad COVID-19. Sin embargo, la prevención es posible, ya que los hábitos de vida saludables pueden reducir el cuadro grave de infección por COVID-19.
Abstract Objective: To identify, in scientific literature, the relationship of obesity as an aggravating risk factor for morbidity by COVID-19. Methods: This is a bibliographic and integrative literature review study, in Brazilian Portuguese, English and Spanish languages, through PICo strategy, in the PubMed, Scopus, Web of Science, Embase and VHL databases, held from May to June 2020. Primary articles conducted with adults, available in full, published during the period 2019 to 2020, in Brazilian Portuguese, English and Spanish were included. Case reports, clinical cases, dissertations, theses, the already selected in the search in another database and that did not answer the question of the search were excluded. Results: The selection resulted in nine studies. Four studies - 44.4% (E3, E5, E6 and E7) - presented the prevalence of obesity in adults hospitalized by COVID-19. Two studies - 22.2% (E6, E9) - associated obesity with the development of severe COVID-19. Three studies - 33.3% (E1, E4 and E7) - associated obesity with the need for mechanical ventilation. Three studies - 33.3% (E2, E4 and E8) - associated obesity with mortality due to COVID-19. Conclusion: Obesity is a chronic non-communicable disease, being a risk factor considered important for the worsening of COVID-19 disease, however, it is preventable, because healthy lifestyle habits can reduce the severe picture of COVID-19 infection.
Subject(s)
Humans , Adult , Databases, Bibliographic , Coronavirus Infections/complications , Coronavirus Infections/physiopathology , Coronavirus Infections/epidemiology , Betacoronavirus , Inpatients , Obesity/complications , Obesity/prevention & control , Obesity/epidemiology , Risk FactorsABSTRACT
ABSTRACT Objective: To analyze factors and behaviors associated with the prevalence of abortion in female partners of prisoners. Methods: Descriptive, cross-sectional study with a quantitative approach carried out with 349 women of inmates in three penitentiaries in the State of Paraná. For data collection, it was used validated instrument BSSB - Brazilian Study on Sexual Behavior. Descriptive analyzes were processed, and through the Chi-square test, the occurrence of abortion and the researched variables were associated. Results: (38.3%) of the women reported abortion throughout their lives, there was an association between women under the age of 30 (p=<0.001), who reported smoking (p=<0.044), not using condoms (p=<0.001), who suffered sexual violence (p = <0.050) and who reported a diagnosis of Sexually Transmitted Infections (p=<0.001). Conclusion: The present study showed associated factors for high prevalence of abortion in women partners of inmates. Abortion is considered an important public health problem and needs to be treated with priority by public health policies in different population groups.
RESUMEN Objetivo: Analizar factores y comportamientos asociados a la prevalencia del aborto en las parejas femeninas de los presos. Métodos: Estudio descriptivo, transversal con enfoque cuantitativo realizado con 349 mujeres presas en tres cárceles del estado de Paraná. Para la recolección de datos, se utilizó un ECOS - Estudio de Comportamiento Sexual en Brasil validado. Se procesaron análisis descriptivos, mediante la prueba de chi-cuadrado, se asociaron la ocurrencia de aborto y las variables estudiadas. Resultados: (38.3%) de las mujeres reportaron aborto a lo largo de su vida, hubo asociación entre mujeres menores de 30 años (p = <0.001), quienes reportaron fumar (p = <0.044), no usar condón (p = <0.001), que sufrieron violencia sexual (p = <0.050) y reportaron un diagnóstico de Infecciones de Transmisión Sexual (p = <0.001). Conclusión: El presente estudio mostró factores asociados a la alta prevalencia de aborto en mujeres condenadas. El aborto se considera un problema importante de salud pública y debe ser tratado con prioridad por las políticas de salud pública en diferentes grupos de población.
RESUMO Objetivo: Analisar fatores e comportamentos associados à prevalência de aborto em mulheres parceiras de apenados. Métodos: Estudo descritivo, transversal de abordagem quantitativa realizado com 349 mulheres de apenados em três penitenciárias no Estado do Paraná. Para coleta dos dados foi utilizado instrumento validado ECOS - Estudo de Comportamento Sexual no Brasil. Processaram-se análises descritivas, e através de teste Qui-quadrado associou-se a ocorrência de aborto e as variáveis pesquisadas. Resultados: (38,3%) das mulheres referiram aborto ao longo da vida, houve associação entre mulheres com idade inferior a 30 anos (p=<0,001), que referiram tabagismo (p=<0,044), não uso de preservativo (p=<0,001), que sofreram violência sexual (p=<0,050) e que relataram diagnóstico de Infecções Sexualmente Transmissíveis (p=<0,001). Conclusão: O presente estudo evidenciou fatores associados para elevada prevalência de aborto em mulheres de apenados. O aborto é considerado importante problema de saúde pública e necessita ser tratado com prioridade pelas políticas públicas de saúde em diferentes grupos populacionais.
ABSTRACT
Objetivo: Relatar a experiência de ser docente no curso de enfermagem em trabalho remoto durante a pandemia da COVID-19. Método: Trata-se de um relato da experiência vivenciada por uma docente no primeiro semestre de 2020, ao ministrar a disciplina intitulada Saúde Ocupacional na modalidade de ensino à distância para um curso de graduação em Enfermagem de uma instituição de ensino superior em uma cidade no Sul do Brasil. Resultados: A partir da experiência vivenciada e da revisão de literatura realizada, identificou-se que as adaptações para o trabalho remoto no contexto de educação podem levar ao sofrimento emocional tanto a partir das vivências de isolamento e distanciamento social, como em função da sobrecarga de trabalho derivada da necessidade de manter as atividades laborais em regime de trabalho remoto. Conclusão: Esse estudo evidenciou desafios a serem enfrentados pelos docentes durante a pandemia, tais como a realização de aulas utilizando-se do trabalho remoto, gerando assim estresse emocional devido à falta de preparo para o mesmo e às dificuldades evidenciadas pelos discentes.
Objective: To report the experience of being a teacher at the nursing course in remote work during the COVID-19 pandemic. Methodology: This is a report of a teacher's lived experience in the first semester of 2020, while teaching the discipline entitled Occupational Health in the distance learning modality for a Nursing undergraduate course in a higher education institution in a city in the South of Brazil. Results: Based on the lived experience and the literature review carried out, it was identified that the adaptations for remote work in the context of education can lead to emotional suffering both from the experiences of isolation and social distancing, as well as from the work overload derived from the need to maintain work activities in a remote work regime. Conclusion: This study evidenced challenges to be faced by teachers during the pandemic, such as the carrying out of classes while working remotely, generating emotional stress due to the lack of preparation for the task and the difficulties evidenced by the students.
Subject(s)
Students, Nursing , Coronavirus Infections , Education, Distance , Faculty, NursingABSTRACT
OBJETIVO: Describir el perfil epidemiológico a través de las características sociodemográficas, obstétricas y del compañero, de casos notificados de sífilis en gestantes y de sífilis congénita, en el período de 2012 a 2016. MÉTODOS: Se trata de un estudio transversal y descriptivo realizado en la 16ª Regional de Salud de Apucarana, en el estado de Paraná, a través de las fichas de notificación compulsoria de sífilis en gestante y sífilis congénita, que constaban en el Sistema de Notificación de Perjuicios y Enfermedades (SINAN). RESULTADOS: Fueron notificados 257 casos de sífilis en gestantes y 119 casos de sífilis congénita. La tasa de prevalencia de sífilis gestacional fue de 0,97% y la tasa de incidencia de sífilis congénita de 4,73%. Las mujeres notificadas como "sífilis en gestante" (SG) y con recién nacido (RN) con "sífilis congénita" (SC), eran en su mayoría, blancas, jóvenes, con baja escolaridad y residían en zona urbana. Los compañeros no tratados totalizaron 40,8%; las madres consideradas con tratamiento inadecuado fueron 47,05%. Entre los nacidos vivos (NV) con SC, 69,7% no realizaron el test treponémico (TT) a los 18 meses y 81,5% no hicieron el test no treponémico (TNT) en el líquido cefalorraquídeo. CONCLUSIÓN: El sistema de salud debe ser reorganizado garantizando el seguimiento y acompañamiento tanto de la gestante como del recién nacido
OBJETIVO: Descrever o perfil epidemiológico através das características sociodemograficas, obstétricas e do parceiro dos casos notificados de sífilis em gestantes e de sífilis congênita no período de 2012 a 2016. MÉTODOS: Trata-se de um estudo transversal e descritivo realizado na 16ª Regional de Saúde de Apucarana do estado do Paraná através das fichas de notificação compulsória de sífilis em gestante e sífilis congênita inseridas no Sistema de Notificação de Agravos e Doenças (SINAN). RESULTADOS: Foram notificados 257 casos de sífilis em gestante e 119 casos de sífilis congênita. A taxa de prevalência de sífilis gestacional foi de 0.97% e a taxa de incidência de sífilis congênita de 4.73%. As mulheres notificadas com sífilis em gestante (SG) e com recém nascido (RN) portador de sífilis congênita (SC) eram em sua maioria, brancas, jovens, com baixa escolaridade e residiam em zona urbana. Parceiros não tratados totalizaram 40,8% e 47.05% das mães foram consideradas com tratamento inadequado. Entre os nascidos vivos (NV) com SC, 69,7% não realizaram o TT aos 18 meses e 81.5% não fizeram o TNT no líquor. CONCLUSÃO: O sistema de saúde deve ser reorganizado garantindo o seguimento e acompanhamento tanto da gestante quanto do recém-nascido
OBJECTIVE: To describe the epidemiological profile through sociodemographic, obstetric and partner characteristics of the notified cases of syphilis in pregnant women in the period of 2012 to 2016. METHODS: This is a cross-sectional and descriptive study conducted at the 16th Apucarana Health Region of the State of Paraná through the compulsory notification sheets for syphilis in pregnant women and congenital syphilis inserted in the Notification System of Diseases and Diseases (SINAN). RESULTS: It was recorded 257 cases of syphilis in pregnant women and 119 cases of congenital syphilis. The prevalent rate of syphilis was 0,97% and the incidence rate of congenital syphilis was 4,73%. Women with congenital syphilis (SG) and congenital syphilis (SC) were mostly white, young, with low schooling and living in urban areas. Untreated partners accounted for 40,8% and 47.05% of the mothers were considered with inadequate treatment. Among live births (NS) with SC, 69.7% did not undergo TT at 18 months and 81.5% did not do TNT in CSF. CONCLUSION: The health system must be reorganized ensuring the follow-up and follow-up of both the pregnant and the newborn
Subject(s)
Humans , Female , Pregnancy , Child , Adolescent , Young Adult , Adult , Middle Aged , Syphilis, Congenital/epidemiology , Syphilis/epidemiology , Pregnancy Complications, Infectious/epidemiology , Treponema pallidum/isolation & purification , Cross-Sectional Studies , Infectious Disease Transmission, Vertical/statistics & numerical data , Neonatal Screening/trends , Treponema pallidum/pathogenicity , Treponemal Infections/nursing , Sexually Transmitted Diseases/epidemiologyABSTRACT
Objetivo: analisar a qualidade de vida e identificar doenças autorreferidas em mulheres de apenados. Método: tratase de um estudo quantitativo, descritivo, transversal, com 349 mulheres de apenados em três penitenciárias. Coletaram-se os dados por meio de dois instrumentos. Analisaram-se as informações por meio da estatística descritiva e regressão linear múltipla. Resultados: consideraram-se inadequados os fatores relativos à qualidade de vida, sendo eles físico (42,1%), psicológico (21,2%), relações sociais (49%), meio ambiente (59%) e geral (53,3%). Constatou-se que a qualidade de vida inadequada se manteve associada a outras doenças (34,7%; p<0,054). Conclusão: torna-se necessário investir em ações estratégicas de promoção da saúde nesta população, pois ela é considerada vulnerável, com predisposição a doenças devido a comportamentos de risco e à qualidade de vida inadequada.(AU)
Objective: to analyze the quality of life and identify self-reported diseases in women inmates. Method: this is a quantitative, descriptive, cross-sectional study with 349 women inmates in three prisons. Data was collected by two instruments. Information was analyzed using descriptive statistics and multiple linear regressions. Results: the factors related to quality of life were inadequate, being physical (42.1%), psychological (21.2%), social relations (49%), environment (59%) and general (53, 3%). Inadequate quality of life was found to be associated with other diseases (34.7%; p <0.054). Conclusion: it is necessary to invest in strategic health promotion actions in this population, as it is considered vulnerable, with a predisposition to disease due to risky behaviors and inadequate quality of life.(AU)
Objetivo: analizar la calidad de vida e identificar enfermedades autoinformadas en mujeres de encarcelados. Método: este es un estudio cuantitativo, descriptivo, transversal, con 349 mujeres de encarcelados en tres cárceles. Los datos fueron recolectados por dos instrumentos. Las informaciones se analizaron mediante estadística descriptiva y regresión lineal múltiple. Resultados: los factores relacionados con la calidad de vida fueron inadecuados, siendo físicos (42.1%), psicológicos (21.2%), relaciones sociales (49%), ambiente (59%) y generales (53, 3%). Se comprobó que la calidad de vida inadecuada estaba asociada con otras enfermedades (34.7%; p <0.054). Conclusión: es necesario invertir en acciones estratégicas de promoción de la salud en esta población, ya que se considera vulnerable, con una predisposición a la enfermedad debido a conductas de riesgo y calidad de vida inadecuada.(AU)
Subject(s)
Humans , Female , Adult , Middle Aged , Prisoners , Quality of Life , Women , Disease , Women's Health , Health Vulnerability , Nursing Care , Epidemiology, Descriptive , Cross-Sectional StudiesABSTRACT
Objective:to describe the cesarean section rates in a university hospital using the Robson Classification. Method:descriptive and cross-sectional, based on data from the Live Birth Information System of deliveries happened in a university hospital, between 2015 and 2017. Results:there was a progressive increase in the route of cesarean delivery and the consequent maintenance of the high general rate of cesarean sections. A considerable number of parturient women had favorable obstetric conditions for vaginal delivery and, if nurse midwives had accompanied them, their chances of having a vaginal delivery could have increased. The greatest group in the Robson Classification was the multiparous group, with previous cesarean section and full-term pregnancy (group 5), which is probably related to the high number of cesarean sections identified in primiparous women (group 1) and the limitations of the labor induction methods. Conclusion:the use of the Robson Classification has enabled us to know, with more specificity, the profile of women submitted to cesarean section in the service, which may subsidize the preparation of more effective strategies and consistent with the reality in coping with high rates of cesarean section.
Objetivo: descrever as taxas de cesáreas de um hospital universitário a partir da Classificação de Robson. Método: descritivo e transversal, realizado a partir de dados do Sistema de Informações de Nascidos Vivos dos partos ocorridos em um hospital universitário, entre 2015 e 2017. Resultados: houve aumento progressivo da via de parto cesárea e a consequente manutenção da elevada taxa geral de cesariana. Quantidade considerável das parturientes possuía condições obstétricas favoráveis para o parto vaginal e, caso tivesse sido acompanhada por enfermeiras (os) obstétricas (os), poderia ter aumentado a sua possibilidade de ter um parto vaginal. O maior grupo da Classificação de Robson foi o de multíparas, com cesárea anterior e gestação a termo (grupo 5), que provavelmente está relacionado ao número elevado de cesariana identificado em primíparas (grupo 1) e a limitações dos métodos de indução para o trabalho de parto. Conclusão: o uso da Classificação de Robson permitiu conhecer, com maior especificidade, o perfil das mulheres submetidas à cesárea no serviço, o que pode subsidiar a elaboração de estratégias mais efetivas e condizentes com a realidade no enfrentamento das taxas elevadas de cesariana.
Subject(s)
Humans , Female , Cesarean Section , Hospitals, University , Parturition , Pregnant Women , Live Birth , Nurse Midwives , ObstetricsABSTRACT
Objective: to estimate the prevalence of factors associated with mental disorders present in users of a psychosocial care center. Method: retrospective documentary study with a quantitative approach. Data were collected from 824 patient records between May and July 2019. A descriptive analysis was performed and the data were presented in the form of absolute and relative frequency, using tabulation, considering p <0.05. Results: there was a greater prevalence of mood disorders in 48.1% of users, stress-related neurotic disorders and somatoform disorders in 18.1%. The sex variable was associated with the diagnosis of mental disorder (p <0.001), and patients under the age of 20 years had a greater prevalence of child and adolescent disorders (35.7%) and mood disorders (32.6%) compared to the other age groups analyzed. Retirees had a higher prevalence of mood disorders (50.7%) and somatoform disorders, where as workers had a higher prevalence (65.7%) of mood disorders. Conclusion: this study will contribute to the planning of actions and permanent education by managers, together with mental health workers, in order to develop different strategies considering differences between sex, age and occupation in relation to the various types of mental disorders verified in the participants of this research.
Objetivo: estimar a prevalência de fatores associados aos transtornos mentais apresentados por usuários de um centro de atenção psicossocial. Método: estudo retrospectivo documental de abordagem quantitativa. Os dados foram coletados em 824prontuários de pacientes entre maio e julho de 2019. Realizou-se análise descritiva e os dados foram apresentados sob forma de frequência absoluta e relativa, utilizando tabulação, considerando p<0, 05.Resultados:verificou-se maior prevalência de transtornos de humor em 48,1% dos usuários, de transtornos neuróticos relacionados ao estresse e transtornos somatoformes em 18,1% deles. A variável sexo associou-se com diagnóstico de transtorno mental (p<0,001), aqueles com idade inferior a 20 anos apresentaram maior prevalência de transtorno infantil e da adolescência (35,7%) e prevalência de transtornos de humor (32,6%) se comparados com as demais faixas etárias analisadas. Aposentados apresentaram maior prevalência de transtornos de humor (50,7%) e transtornos somatoformes; os pacientes trabalhadores apresentaram maior prevalência (65,7%) de transtornos do humor. Conclusão: este estudo contribuirá para o planejamento de ações e de educação permanente por parte de gestores, em conjunto com trabalhadores da saúde mental, de forma a elaborar estratégias diferenciadas considerando diferenças entre sexo, idade e ocupação em relação aos vários tipos de transtornos mentais verificados nos participantes desta pesquisa