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1.
J Obstet Gynaecol Res ; 48(1): 256-261, 2022 Jan.
Article in English | MEDLINE | ID: mdl-34704313

ABSTRACT

This is the first known case report of severe intrauterine adhesion (IUA) following a life-threatening event caused by an Epstein-Barr virus-associated atraumatic spleen laceration. A 22-year-old nulligravid female suffered from infectious mononucleosis for approximately 1 month. Sudden severe hypovolemic shock with massive hemoperitoneum appeared and hemostasis was completely achieved by a splenectomy for an atraumatic spleen laceration, although that was followed by multiorgan failure and abdominal compartment syndrome. Complete recovery without any neurological sequelae was achieved by intensive treatment. A postoperative pathological evaluation revealed Epstein-Barr virus-associated splenomegaly. The patient was referred to our department because of secondary amenorrhea for approximately 5 months since the last menstruation, which occurred just prior to the event. Laboratory blood test results demonstrated normal thyroid and ovarian functions. Hysterofiberscopy revealed complete obstruction at the end of the cervical canal, indicating secondary uterine amenorrhea caused by severe IUA. Hysteroscopic adhesiolysis with a rigid hysteroscope reached the opening of the uterine cavity and menstruation was restored.


Subject(s)
Epstein-Barr Virus Infections , Lacerations , Uterine Diseases , Adult , Female , Herpesvirus 4, Human , Humans , Spleen , Tissue Adhesions/surgery , Young Adult
2.
Case Rep Womens Health ; 24: e00149, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31700808

ABSTRACT

Abdominal pregnancy is a rare form of ectopic pregnancy. Various sites of implantation in abdominal pregnancy have been reported. Uterine serosa is an extremely rare implantation site, with only a few cases reported to date. No case of abdominal pregnancy implanted on the surface of a subserosal uterine leiomyoma has been reported. We herein report the case of a 40-year-old primigravida woman who was diagnosed with abdominal pregnancy implanted on the surface of a pedunculated subserosal uterine leiomyoma. The uterine leiomyoma with gestational tissue was resected laparoscopically and the postoperative course was uneventful. It is necessary to remember the possibility of unexpected implantation sites and that laparoscopic surgery may be more difficult in such cases than that for fallopian tube pregnancy.

3.
IDCases ; 17: e00578, 2019.
Article in English | MEDLINE | ID: mdl-31309037

ABSTRACT

Helicobacter cinaedi is a rarely encountered pathogen that easily induces bacteremia. Various foci of H. cinaedi infection have been reported; however, no case of adnexal abscess caused by H. cinaedi has been reported in the English literature. We herein report a case of ovarian abscess caused by H. cinaedi. A 38-year-old nulligravid Japanese woman was admitted to our hospital with an adnexal abscess. Clinical findings included fever, leukocytosis, and elevated C-reactive protein. Laparoscopic right partial oophorectomy with abdominal lavage was performed. H. cinaedi was isolated from cultures of blood and ovarian abscess fluid after surgery. Intravenous ampicillin/sulbactam was administered for 2 weeks, followed by oral amoxicillin for an additional 2 weeks. The postoperative course was uneventful and clinical findings improved. There was no evidence of relapse. H. cinaedi can cause ovarian abscess and is likely an under-recognized pathogen.

4.
J Obstet Gynaecol Res ; 44(3): 583-587, 2018 Mar.
Article in English | MEDLINE | ID: mdl-29239064

ABSTRACT

Condylomatous, or warty squamous cell carcinoma (SCC) of the uterine cervix, is a rare variant of invasive SCC. Here, we describe a case of aggressive condylomatous SCC of the uterine cervix. A 43-year-old woman was monitored for 3 years for suspected low-grade squamous intraepithelial lesion. A whitish papillary mass occupied the cervix, and the colposcopic diagnosis was condyloma acuminatum. A cervical biopsy revealed papillary proliferating thick squamous epithelium, which consisted of koilocytes and atypical cells with enlarged nuclei. Hysterectomy specimens showed a thick layer of atypical squamous epithelium with koilocytosis invading the stroma. Immunohistochemistry revealed negative p16 expression. Hysterectomy specimens tested positive for low-risk human papillomavirus type 6, but negative for other high-risk human papillomavirus types. The bilateral pelvic and para-aortic lymph nodes were positive for metastases. In spite of adjuvant chemotherapy, the case relapsed with multiple lymph nodes and lung metastases shortly after the operation.


Subject(s)
Carcinoma, Squamous Cell/diagnosis , Condylomata Acuminata/diagnosis , Disease Progression , Human papillomavirus 6/pathogenicity , Papillomavirus Infections/diagnosis , Uterine Cervical Neoplasms/diagnosis , Adult , Carcinoma, Squamous Cell/etiology , Condylomata Acuminata/etiology , Female , Humans , Papillomavirus Infections/complications , Uterine Cervical Neoplasms/etiology
5.
Org Lett ; 11(20): 4652-5, 2009 Oct 15.
Article in English | MEDLINE | ID: mdl-19751053

ABSTRACT

Inter- and intramolecular additions of alkyl radicals, generated by SET photochemical decarboxylation reactions of free carboxylic acids, to electron-deficient alkenes take place under mild conditions as part of efficient routes for the formation of N-Boc gamma-amino acids and macrocyclic lactones.


Subject(s)
Alkanes/chemistry , Alkenes/chemistry , Amino Acids/chemistry , Carboxylic Acids/chemistry , Electrons , Lactones/chemistry , Photochemical Processes , Electron Transport , Macrocyclic Compounds/chemistry
6.
Biol Pharm Bull ; 26(2): 148-55, 2003 Feb.
Article in English | MEDLINE | ID: mdl-12576672

ABSTRACT

The Na+/H+ exchangers (NHEs) comprise a family of membrane proteins that catalyze the electroneutral exchange of Na+ and H+. Calcineurin homologous protein (CHP) acts as a crucial cofactor for NHE activity through direct interaction with the carboxyl-terminal tail region of NHEs. We have cloned a new rat CHP isoform (rCHP2) and characterized the binding property to NHEs and the tissue distribution. rCHP2 binds to the juxtamembrane region of plasma membrane-type NHE isoforms (NHE1-5) in vivo and in vitro as well as rCHP1 (original rat CHP). Interestingly, CHP2 is predominantly expressed in the small and large intestine although rCHP1 shows relatively ubiquitous expression at both the mRNA and protein levels. In situ hybridization experiments demonstrated the abundant expression of CHP2 in the epithelial cell layer of villi of the small intestine in contrast with the expression of CHP1 in both the epithelial layer and connective tissues. These results suggest that CHP2 functions in the absorptive epithelium for the intestine with NHE(s).


Subject(s)
Avian Proteins , Calcium-Binding Proteins/biosynthesis , Calcium-Binding Proteins/genetics , Defensins , Intestinal Mucosa/metabolism , Sodium-Hydrogen Exchangers/biosynthesis , Sodium-Hydrogen Exchangers/genetics , Amino Acid Sequence , Animals , Antimicrobial Cationic Peptides , Base Sequence , Cell Line , Chlorocebus aethiops , Cricetinae , Dogs , Gene Expression Regulation/physiology , Humans , Mice , Molecular Sequence Data , Opossums , Protein Binding/physiology , Protein Isoforms/biosynthesis , Protein Isoforms/genetics , Rats , Rats, Wistar , Swine
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