Chemistry must respond to the crisis of transgression of planetary boundaries.

Recent assessments alarmingly indicate that many of the world's leading chemicals are transgressing one or more of the nine planetary boundaries, which define safe operating spaces within which humanity can continue to develop and thrive for generations to come. The unfolding crisis cannot be ignored and there is a once-in-a-century opportunity for chemistry - the science of transformation of matter - to make a critical difference to the future of people and planet. How can chemists contribute to meeting these challenges and restore stability and strengthen resilience to the planetary system that humanity needs for its survival? To respond to the wake-up call, three crucial steps are outlined: (1) urgently working to understand the nature of the looming threats, from a chemistry perspective; (2) harnessing the ingenuity and innovation that are central to the practice of chemistry to develop sustainable solutions; and (3) transforming chemistry itself, in education, research and industry, to re-position it as 'chemistry for sustainability' and lead the stewardship of the world's chemical resources. This will require conservation of material stocks in forms that remain available for use, through attention to circularity, as well as strengthening engagement in systems-based approaches to designing chemistry research and processes informed by convergent working with many other disciplines.

The Challenge of Reaching Undocumented Migrants with COVID-19 Vaccination.

Access to vaccination against a health threat such as that presented by the COVID-19 pandemic is an imperative driven, in principle, by at least three compelling factors: (1) the right to health of all people, irrespective of their status; (2) humanitarian need of undocumented migrants, as well as of others including documented migrants, refugees and displaced people who are sometimes vulnerable and living in precarious situations; and (3) the need to ensure heath security globally and nationally, which in the case of a global pandemic requires operating on the basis that, for vaccination strategies to succeed in fighting a pandemic, the highest possible levels of vaccine uptake are required. Yet some population segments have had limited access to mainstream health systems, both prior to as well as during the COVID-19 pandemic. People with irregular resident status are among those who face extremely high barriers in accessing both preventative and curative health care. This is due to a range of factors that drive exclusion, both on the supply side (e.g., systemic and practical restrictions in service delivery) and the demand side (e.g., in uptake, including due to fears that personal data would be transmitted to immigration authorities). Moreover, undocumented people have often been at increased risk of infection due to their role as "essential workers", including those experiencing higher exposure to the SARS-CoV-2 virus due to frontline occupations while lacking protective equipment. Often, they have also been largely left out of social protection measures granted by governments to their populations during successive lockdowns. This article reviews the factors that serve as supply-side and demand-side barriers to vaccination for undocumented migrants and considers what steps need to be taken to ensure that inclusive approaches operate in practice.

A shared future: chemistry's engagement is essential for resilience of people and planet.

Strengthening resilience-elasticity or adaptive capacity-is essential in responding to the wide range of natural hazards and anthropogenic changes humanity faces. Chemistry's roles in resilience are explored for the first time, with its technical capacities set in the wider contexts of cross-disciplinary working and the intersecting worlds of science, society and policy. The roles are framed by chemistry's contributions to the sustainability of people and planet, examined via the human security framework's four material aspects of food, health, economic and environmental security. As the science of transformation of matter, chemistry is deeply involved in these material aspects and in their interfacing with human security's three societal and governance aspects of personal, community and political security. Ultimately, strengthening resilience requires making choices about the present use of resources as a hedge against future hazards and adverse events, with these choices being co-determined by technical capacities and social and political will. It is argued that, to intensify its contributions to resilience, chemistry needs to take action along at least three major lines: (i) taking an integrative approach to the field of 'chemistry and resilience'; (ii) rethinking how the chemical industry operates; and (iii) engaging more with society and policy-makers.

COVID-19: Marking the Gaps in Migrant and Refugee Health in Some Massive Migration Areas.

The health of migrants and refugees, which has long been a cause for concern, has come under greatly increased pressure in the last decade. Against a background where the world has witnessed the largest numbers of migrants in history, the advent of the COVID-19 pandemic has stretched the capacities of countries and of aid, health and relief organizations, from global to local levels, to meet the human rights and pressing needs of migrants and refugees for access to health care and to public health measures needed to protect them from the pandemic. The overview in this article of the situation in examples of middle-income countries that have hosted mass migration in recent years has drawn on information from summaries presented in an M8 Alliance Expert Meeting, from peer-reviewed literature and from reports from international agencies concerned with the status and health of migrants and refugees. The multi-factor approach developed here draws on perspectives from structural factors (including rights, governance, policies and practices), health determinants (including economic, environmental, social and political, as well as migration itself as a determinant) and the human security framework (defined as "freedom from want and fear and freedom to live in dignity" and incorporating the interactive dimensions of health, food, environmental, economic, personal, community and political security). These integrate as a multi-component 'ecological perspective' to examine the legal status, health rights and access to health care and other services of migrants and refugees, to mark gap areas and to consider the implications for improving health security both for them and for the communities in countries in which they reside or through which they transit.

Re-imagining Priorities for Chemistry: A Central Science for "Freedom from Fear and Want".

Human security, defined as "freedom from want and fear and freedom to live in dignity", provides an overarching concept to address threats to human security dimensions such as health, food, economics, the environment and sustainable development, while placing the individual at the centre of attention. Chemistry is central to addressing these challenges, but surprisingly its role and contributions to human security have hitherto not been explicitly set out. This article situates chemistry in the human security framework, highlighting areas where chemistry knowledge, methods and products are vital. It underscores three complementary facets: 1) chemistry contributes to many dimensions of human security, but needs to do much more in the light of oncoming global challenges; 2) the human security framing illuminates areas where chemistry itself needs to adapt to contribute better, by intensification of current approaches and/or by building or strengthening chemistry tools, skills and competencies; and 3) repositioning as central to human security affords chemistry a powerful opportunity to refresh itself as a science for the benefit of society-and it will need to engage more directly and dynamically at the interface of science, society and policy in order to do so.

Realigning science, society and policy in uncertain times.

Against a backdrop of rapidly changing social, economic and geopolitical settings and ideologies, the world is facing a wide range of challenges, including in biodiversity, climate, energy, the environment, food, health and water. These can only be addressed by fully harnessing key capacities that science offers. However, there is a crisis of trust in science which affects some sections of society and some policy-makers, impairing the capacity of science to deliver its essential roles. This damaged relationship between science, society and policy has immense health, economic and social consequences and implications for sustainability of the entire planet. Scientists must strive collectively to re-establish trust by society and politicians where it is damaged, and reinforce conviction of science's central importance in underpinning policy. Science's roles must in turn be acknowledged by policies that sustain innovation and freedom to work without political interference or constraints. A well-functioning and trusting relationship between science, society and policy-makers offers a potent means to thwart and mitigate emergent global challenges.

Blocking the Hype-Hypocrisy-Falsification-Fakery Pathway is Needed to Safeguard Science.

In chemistry and other sciences, hype has become commonplace, compounded by the hypocrisy of those who tolerate or encourage it while disapproving of the consequences. This reduces the credibility and trust upon which all science depends for support. Hype and hypocrisy are but first steps down a slippery slope towards falsification of results and dissemination of fake science. Systemic drivers in the contemporary structure of the science establishment encourage exaggeration and may lure the individual into further steps along the hype-hypocrisy-falsification-fakery continuum. Collective, concerted intervention is required to effectively discourage entry to this dangerous pathway and to restore and protect the probity and reputation of the science system. Chemists must play and active role in this effort.

Fake science and the knowledge crisis: ignorance can be fatal.

Computers, the Internet and social media enable every individual to be a publisher, communicating true or false information instantly and globally. In the 'post-truth' era, deception is commonplace at all levels of contemporary life. Fakery affects science and social information and the two have become highly interactive globally, undermining trust in science and the capacity of individuals and society to make evidence-informed choices, including on life-or-death issues. Ironically, drivers of fake science are embedded in the current science publishing system intended to disseminate evidenced knowledge, in which the intersection of science advancement and reputational and financial rewards for scientists and publishers incentivize gaming and, in the extreme, creation and promotion of falsified results. In the battle for truth, individual scientists, professional associations, academic institutions and funding bodies must act to put their own house in order by promoting ethics and integrity and de-incentivizing the production and publishing of false data and results. They must speak out against false information and fake science in circulation and forcefully contradict public figures who promote it. They must contribute to research that helps understand and counter false information, to education that builds knowledge and skills in assessing information and to strengthening science literacy in society.

The Need for Cultural Competence in Science: A Practical Approach to Enhancing Equality, Diversity, and Inclusion.

"The entire field of science needs to enhance its performance with regard to equality, diversity, and inclusion …" Read more in the Editorial by S. A. Matlin, V. W. W. Yam et al.

Living Messages from Chemistry Icons: Legacies with Contemporary Relevance.

Beyond individual scientific virtuosity and creativity that leading figures in chemistry have displayed, they have sometimes conveyed wider messages of significance beyond their own professional specialization. They include insights into broader aspects of science, society or the ways of the world. On the other hand, the words, attitudes and actions of eminent chemists from former times have not always presented good models for others to follow, whether judged by their own contemporary or our present standards. Both positive and negative lessons may convey to us something about humanity in general or the nature of our current predicaments and challenges. In an era when science is more necessary than ever to help meet oncoming global challenges, yet the principles and results of science are irrationally questioned, it is particularly relevant to re-connect with the broad insights and messages that can be derived from examining the thoughts and deeds of chemistry icons from the past.

The Chemical Sciences and Equality, Diversity, and Inclusion.

There has been mounting concern over the absence of gender equality in the sciences in recent years. This has been accompanied by a broadening of the perspective, in order to address issues of equality, diversity and inclusion, relating to a wide range of circumstances in which individuals suffer discrimination. While some progress has been made in some countries, nationally or at the level of institutions, much more needs to be done. The chemical sciences can play a leading role in addressing biases, through 1) becoming a model of good systemic practice in policies, processes, and actions; 2) developing practical skills through training in cultural competence; and 3) promoting a stronger evidence base to uncover both the extent of problems and the degree to which approaches to improve equality, diversity, and inclusion are working.

The Chemical Sciences and Health: Strengthening Synergies at a Vital Interface.

The indispensable contributions to health made by the chemical sciences have become increasingly constrained by three systemic factors. These involve fragmentations: in the way that the chemicals sciences are structured, practiced, and inter-related to aspects of health; in the combination of public and private efforts delivering medicinal products; and in the regulatory systems which oversee health-related issues across health, food, and the environment. Interlinked systemic reforms are advocated, involving (1) recontextualization of the chemistry/health interface through creating a recognized field of "the chemical sciences and health"; (2) determined and comprehensive efforts, by countries wishing to retain or strengthen their pharmaceutical development capacities, to reinforce their education, research, and innovation eco-systems; and (3) adoption of an integrated approach to the regulation of pharmaceuticals, food, and the environment.

Mapping of available health research and development data: what's there, what's missing, and what role is there for a global observatory?

The need to align investments in health research and development (R&D) with public health demands is one of the most pressing global public health challenges. We aim to provide a comprehensive description of available data sources, propose a set of indicators for monitoring the global landscape of health R&D, and present a sample of country indicators on research inputs (investments), processes (clinical trials), and outputs (publications), based on data from international databases. Total global investments in health R&D (both public and private sector) in 2009 reached US$240 billion. Of the US$214 billion invested in high-income countries, 60% of health R&D investments came from the business sector, 30% from the public sector, and about 10% from other sources (including private non-profit organisations). Only about 1% of all health R&D investments were allocated to neglected diseases in 2010. Diseases of relevance to high-income countries were investigated in clinical trials seven-to-eight-times more often than were diseases whose burden lies mainly in low-income and middle-income countries. This report confirms that substantial gaps in the global landscape of health R&D remain, especially for and in low-income and middle-income countries. Too few investments are targeted towards the health needs of these countries. Better data are needed to improve priority setting and coordination for health R&D, ultimately to ensure that resources are allocated to diseases and regions where they are needed the most. The establishment of a global observatory on health R&D, which is being discussed at WHO, could address the absence of a comprehensive and sustainable mechanism for regular global monitoring of health R&D.

Health innovation networks to help developing countries address neglected diseases.

Gross inequities in disease burden between developed and developing countries are now the subject of intense global attention. Public and private donors have marshaled resources and created organizational structures to accelerate the development of new health products and to procure and distribute drugs and vaccines for the poor. Despite these encouraging efforts directed primarily from and funded by industrialized countries, sufficiency and sustainability remain enormous challenges because of the sheer magnitude of the problem. Here we highlight a complementary and increasingly important means to improve health equity: the growing ability of some developing countries to undertake health innovation.