Providing comfort to critically ill pediatric patients: isoflurane.

Isoflurane is a fluorinated ether used primarily as an inhalation anesthetic. Rapid titratable effects, limited metabolism, and a reliable mode of administration make isoflurane an appealing alternative to the use of intravenous sedatives and narcotics in critically ill patients requiring prolonged mechanical ventilation. This article, in reviewing this novel approach to management of patient discomfort, focuses on nursing practice issues and provides a critical analysis of isoflurane use in the intensive care unit.