ABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Thrombosis/etiology , Coronavirus Infections/complications , Pneumonia, Viral/complications , Blood Coagulation Disorders/virology , Skin Diseases/diagnosis , Thrombosis/blood , Thrombosis/drug therapy , Coronavirus Infections/blood , Pneumonia, Viral/blood , Respiratory Insufficiency/complications , Skin Diseases/complications , Skin Diseases/drug therapy , Anticoagulants , BiopsySubject(s)
Betacoronavirus , Coronavirus Infections/diagnosis , Pneumonia, Viral/diagnosis , Thrombosis/virology , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques , Computed Tomography Angiography , Coronavirus Infections/complications , Female , Humans , Middle Aged , Pandemics , Pneumonia, Viral/complications , SARS-CoV-2 , Thrombosis/diagnosis , Thrombosis/pathologyABSTRACT
Congenital melanocytic nevi (CMN) are benign melanocytic proliferations that are usually present at birth. A somatic mosaicism for an NRAS point mutation is responsible for the several phenotypic abnormalities that may be associated with congenital nevi. We report the case of a 7-year-old boy with a proliferative nodule (PN) arising in a Giant CMN completely excised and with several visceral and intraspinal melanoma metastases with no evidence of primary cutaneous melanoma. The careful analysis of the clinical, morphologic, and molecular features allowed the distinction of between the benign PN (BPN) and the melanoma. The BPN showed a characteristic comparative genomic hybridization pattern with gains or losses of whole chromosomes, whereas the melanoma displayed gains or losses involving complex partial chromosomal copy number gains or losses. Leptomeningeal melanocytes are more susceptible to transformation by oncogenic NRAS than cutaneous melanocytes, and central nervous system melanomas are more common than cutaneous melanomas in the setting of CMN. Thus, it has been recommended to characterize the congenital disease in patients with 2 CMN at birth, independently of size and site, with a single magnetic resonance imaging screening younger than the age of 1 year.
Subject(s)
GTP Phosphohydrolases/genetics , Melanoma/genetics , Membrane Proteins/genetics , Nevus, Pigmented/genetics , Skin Neoplasms/genetics , Child , Humans , Male , Melanoma/pathology , Mutation , Neoplasm Metastasis/genetics , Neoplasm Metastasis/pathology , Nevus, Pigmented/pathology , Skin Neoplasms/pathology , Melanoma, Cutaneous MalignantABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Skin Ulcer/etiology , Trigeminal Nerve Injuries/complications , Hypesthesia/complicationsSubject(s)
Antibodies, Monoclonal, Humanized/adverse effects , Immunotherapy , Nevus/drug therapy , Panniculitis/chemically induced , Peritoneal Neoplasms/drug therapy , Skin Neoplasms/drug therapy , Skin/pathology , Antibodies, Monoclonal, Humanized/therapeutic use , Antineoplastic Agents, Immunological/adverse effects , Antineoplastic Agents, Immunological/therapeutic use , Disease Progression , Female , Follow-Up Studies , Humans , Middle Aged , Nevus/diagnosis , Panniculitis/diagnosis , Peritoneal Neoplasms/diagnosis , Peritoneal Neoplasms/secondary , Programmed Cell Death 1 Receptor , Skin Neoplasms/pathology , Tomography, X-Ray ComputedSubject(s)
Alternariosis/pathology , Communicable Diseases, Emerging/diagnosis , Immunocompromised Host/immunology , Kidney Transplantation/methods , Phaeohyphomycosis/pathology , Phaeohyphomycosis/therapy , Aged , Alternariosis/immunology , Alternariosis/therapy , Antifungal Agents/therapeutic use , Biopsy, Needle , Combined Modality Therapy , Communicable Diseases, Emerging/epidemiology , Communicable Diseases, Emerging/therapy , Dermatologic Surgical Procedures/methods , Europe , Female , Humans , Immunohistochemistry , Lower Extremity , Opportunistic Infections/diagnosis , Opportunistic Infections/immunology , Prognosis , Treatment OutcomeABSTRACT
No disponible
Subject(s)
Humans , Female , Middle Aged , Everolimus/metabolism , Everolimus/pharmacology , Everolimus/therapeutic use , Sarcoma, Kaposi/complications , Sarcoma, Kaposi/drug therapy , Liver Transplantation , End Stage Liver Disease/complications , Skin Diseases/complications , Skin Diseases/drug therapy , Doxorubicin/therapeutic use , Immunosuppression Therapy/trendsSubject(s)
Antineoplastic Agents/therapeutic use , Everolimus/therapeutic use , Immunosuppressive Agents/therapeutic use , Liver Transplantation , Mouth Neoplasms/drug therapy , Postoperative Complications/drug therapy , Sarcoma, Kaposi/drug therapy , Female , Graft Rejection/prevention & control , Humans , Middle Aged , Mouth Neoplasms/diagnosis , Mouth Neoplasms/etiology , Mouth Neoplasms/pathology , Postoperative Complications/diagnosis , Postoperative Complications/pathology , Sarcoma, Kaposi/diagnosis , Sarcoma, Kaposi/etiology , Sarcoma, Kaposi/pathologyABSTRACT
No disponible
Subject(s)
Humans , Adult , Anetoderma/diagnosis , Elastic Tissue/physiopathology , Risk Factors , Biomarkers/analysis , Protein S Deficiency/diagnosisABSTRACT
Classically known as the "Great Imitator", the diagnosis of syphilis continues to be an enormous challenge. We describe a case of isolated oral lesions as the sole presentation of secondary syphilis and only clinical clue to previously undiagnosed human immunodeficiency virus infection. The current increase in new cases of syphilis is leading to reemergence of forgotten old scenarios, which physicians should bear in mind within the differential diagnosis of their daily practice.
