BACKGROUND: Satellitosis or in-transit metastasis (S-ITM) has clinical outcomes comparable to node-positivity in cutaneous squamous cell carcinoma (cSCC). There is a need to stratify the risk groups. OBJECTIVE: To determine which prognostic factors of S-ITM confer an increased risk of relapse and cSCC-specific-death. METHODS: A retrospective, multicenter cohort study. Patients with cSCC developing S-ITM were included. Multivariate competing risk analysis evaluated which factors were associated with relapse and specific death. RESULTS: Of a total of 111 patients with cSCC and S-ITM, 86 patients were included for analysis. An S-ITM size of ≥20 mm, >5 S-ITM lesions, and a primary tumor deep invasion was associated with an increased cumulative incidence of relapse (subhazard ratio [SHR]: 2.89 [95% CI, 1.44-5.83; P = .003], 2.32 [95% CI, 1.13-4.77; P = .021], and 2.863 [95% CI, 1.25-6.55; P = .013]), respectively. Several >5 S-ITM lesions were also associated with an increased probability of specific death (SHR: 3.48 [95% CI, 1.18-10.2; P = .023]). LIMITATIONS: Retrospective study and heterogeneity of treatments. CONCLUSION: The size and the number of S-ITM lesions confer an increased risk of relapse and the number of S-ITM an increased risk of specific-death in patients with cSCC presenting with S-ITM. These results provide new prognostic information and can be considered in the staging guidelines.
Carcinoma, Squamous Cell , Skin Neoplasms , Humans , Carcinoma, Squamous Cell/pathology , Cohort Studies , Retrospective Studies , Prognosis , Skin Neoplasms/pathology , Neoplasm Recurrence, Local/epidemiology , Neoplasm Recurrence, Local/pathology , Risk Factors , Recurrence , Neoplasm Staging
Alopecia/diagnosis , Dermoscopy , Hair Follicle/diagnostic imaging , Lupus Erythematosus, Discoid/complications , Adult , Aged , Aged, 80 and over , Alopecia/immunology , Alopecia/pathology , Biopsy , Cross-Sectional Studies , Female , Hair Follicle/pathology , Humans , Lupus Erythematosus, Discoid/immunology , Male , Middle Aged
Coronavirus Infections/drug therapy , Interleukin 1 Receptor Antagonist Protein/therapeutic use , Pneumonia, Viral/drug therapy , Betacoronavirus , COVID-19 , Humans , Injections, Subcutaneous , Interleukin 1 Receptor Antagonist Protein/administration & dosage , Male , Middle Aged , Pandemics , SARS-CoV-2 , Treatment Outcome
Aminolevulinic Acid/analogs & derivatives , Eyelid Neoplasms/drug therapy , Nevus, Sebaceous of Jadassohn/drug therapy , Photochemotherapy , Photosensitizing Agents/therapeutic use , Adolescent , Adult , Aminolevulinic Acid/therapeutic use , Cheek , Child , Child, Preschool , Female , Humans , Male , Photochemotherapy/adverse effects , Photochemotherapy/methods , Retrospective Studies , Treatment Outcome , Young Adult
Glomuvenous malformations are uncommon simple vascular malformations that might be present at birth or appear during childhood that have been classically classified as a subtype of venous malformations. Sclerotherapy and surgery have been used in the past as treatments for this condition although with disappointing results in large glomangiomas. The treatment of these lesions has still not been standardized. We conducted a retrospective study of 17 patients treated with dual wavelength PDL-Nd:YAG. The majority of the patients experience a reduction of at least a 60% in their glomuvenous malformations. Treatment was well-tolerated, and adverse effects were rare.
Glomus Tumor/radiotherapy , Lasers, Solid-State , Paraganglioma, Extra-Adrenal/radiotherapy , Adolescent , Adult , Child , Female , Humans , Lasers, Dye , Male , Middle Aged , Retrospective Studies , Young Adult
Melanoma/diagnosis , Skin Neoplasms/diagnosis , Biopsy , DNA Mutational Analysis , Female , Humans , Liver Neoplasms/genetics , Liver Neoplasms/pathology , Liver Neoplasms/secondary , Lung Neoplasms/genetics , Lung Neoplasms/pathology , Lung Neoplasms/secondary , Lymphatic Metastasis/genetics , Lymphatic Metastasis/pathology , Melanoma/genetics , Melanoma/pathology , Middle Aged , Neoplasm Metastasis , Positron Emission Tomography Computed Tomography , Proto-Oncogene Proteins B-raf/genetics , Scapula , Skin/pathology , Skin Neoplasms/genetics , Skin Neoplasms/pathology , Melanoma, Cutaneous Malignant
BACKGROUND: Frontal fibrosing alopecia (FFA) is a scarring alopecia characterized by recession of the frontotemporal hairline and loss of the eyebrows. OBJECTIVE: To design and validate a scoring system to assess the severity of FFA. METHODS: The Frontal Fibrosing Alopecia Severity Score (FFASS) was developed; criterion validity was assessed by the Investigator's Global Assessment, and construct validity was evaluated by the convergence of other measures of severity (the Patient's Global Assessment], the rest of the clinical features, the Lichen Planopilaris Activity Index, and quality of life measures (Dermatology Life Quality Index and Hospital Anxiety Depression Scale). Intraobserver and interobserver reliability were determined. RESULTS: In total, 103 female patients were included. The FFASS showed significant correlation to the Patient's Global Assessment, occipital involvement, and the Lichen Planopilaris Activity Index. Intraobserver reliability was completed for 31 subjects and showed good correlation (intraclass correlation coefficient, 0.86; 95% confidence interval, 0.7-0.95; P < .001). Interobserver reliability showed excellent correlation (intraclass correlation coefficient, 0.97; 95% confidence interval, 0.95-0.99; P < .001). LIMITATIONS: The study was performed at a single institution, and only female patients were assessed. CONCLUSIONS: The FFASS is a statistically validated scale and a reliable measure of FFA severity, and it can be used in clinical practice and future research studies as an assessment tool.
Alopecia/complications , Severity of Illness Index , Skin/pathology , Adult , Aged , Aged, 80 and over , Cicatrix/etiology , Erythema/etiology , Eyebrows , Female , Fibrosis , Forehead , Humans , Keratosis/etiology , Middle Aged , Observer Variation , Pain/etiology , Pruritus/etiology , Reproducibility of Results
