ABSTRACT
Method of surgical chemotherapy on organism automedia during surgical procedures for breast and colon malignant tumors has been developed. The method consists in intravenous autohemochemotherapy and local autoplasmochemotherapy (into residuary mammary tissue or regional arterial mesenteric vessel).
Subject(s)
Antineoplastic Agents/administration & dosage , Blood Transfusion, Autologous/methods , Breast Neoplasms/drug therapy , Colectomy/methods , Colonic Neoplasms/drug therapy , Mastectomy/methods , Antineoplastic Agents/therapeutic use , Breast Neoplasms/pathology , Breast Neoplasms/surgery , Chemotherapy, Adjuvant , Colonic Neoplasms/pathology , Colonic Neoplasms/surgery , Follow-Up Studies , Humans , Injections, Intravenous , Intraoperative Period , Male , Middle Aged , Neoplasm Staging , Treatment OutcomeABSTRACT
An earlier investigation of the superoxide-neutralizing activity of blood serum sampled from patients with primary multiple malignancies detected for the first time RF-proteins as well as their tropism to the target organ from which tumor was removed 2-30 years before. A possible explanation may be that a general reaction of the body presented itself. The present study has led to a conclusion that, in cases of polyneoplasia, successful complex treatment of primary malignancy, carried out however for back, might be masked by RF-protein function: the latter "indicates" the presence of foci of malignancy which are not there any longer.
Subject(s)
Intermediate Filament Proteins/metabolism , Neoplasms, Multiple Primary/metabolism , Nerve Tissue Proteins/metabolism , Protein Kinases , Superoxides/metabolism , Humans , Neoplasms, Multiple Primary/blood , alpha-Crystallin B ChainABSTRACT
Changes in antioxidant characteristics of blood in patients with inoperable tumors of the stomach were followed before and after combination polychemotherapy which comprised intraperitoneal and endolymphatic injection of drugs. General strengthening therapy was given prior to treatment. It was found that enzymatic activity as a component of antioxidant defenses offered by lymphocytes is low in such patients which adversely affects the structural and functional integrity of lymphocyte membranes. After chemotherapy, said function improved significantly showing a tendency towards normalizing. This effect correlated with clinical improvement and better quality of life in patients with inoperable gastric tumors.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antioxidants/metabolism , Lymphocytes/drug effects , Oxidative Stress/drug effects , Stomach Neoplasms/blood , Stomach Neoplasms/drug therapy , Adult , Aged , Blood Physiological Phenomena/drug effects , Female , Humans , Male , Middle AgedABSTRACT
Due to errors in the planning and development of cancer hospital system there is a gap between the present-day cancer morbidity levels and the number and profile of oncological hospital beds. Fresh approaches to cancer control planning are required. Improvement in treatment strategies is an important factor of cancer in--patient service development.
Subject(s)
Cancer Care Facilities/organization & administration , Hospitals, Special/organization & administration , Bed Occupancy , Hospital Bed Capacity , Humans , Neoplasms/diagnosis , Neoplasms/epidemiology , Neoplasms/therapy , Patient Care Planning/organization & administration , Russia , WorkforceSubject(s)
Health Resorts , Postoperative Care/methods , Stomach Neoplasms/therapy , Adult , Evaluation Studies as Topic , Female , Humans , Male , Middle Aged , Postgastrectomy Syndromes/therapy , RussiaABSTRACT
The results are reported on the effect of endolymphatic administration of large doses of 5-fluorouracil and methotrexate on the rate of motion and the coefficient of the motion activity of leucocytes in peripheral blood in 20 gastric cancer patients. The functional changes were found to precede quantitative shifts in leucocytes. Two weeks after termination of the chemotherapy the rate of leucocytes motion and CMA restored to the initial values.
Subject(s)
Fluorouracil/administration & dosage , Leukocytes/drug effects , Methotrexate/administration & dosage , Stomach Neoplasms/drug therapy , Adult , Aged , Cell Movement/drug effects , Drug Therapy, Combination , Female , Foot , Humans , Injections, Intralymphatic , Male , Middle Aged , Postoperative Period , Preoperative Care , Time FactorsSubject(s)
Antineoplastic Agents/administration & dosage , Lymphocyte Activation , Stomach Neoplasms/immunology , Adult , Aged , Antineoplastic Agents/pharmacology , Drug Therapy, Combination/methods , Humans , Injections, Intralymphatic , Lymphocyte Activation/drug effects , Middle Aged , Preoperative Care , Stomach Neoplasms/drug therapy , Stomach Neoplasms/surgeryABSTRACT
Study on the balance of sex hormones in 43 males and 45 females with gastric cancer indicated the presence of some deviations from normal level of androgens and estrogens excretion in gastric cancer patients. The character and intensity of the deviations observed were dependent on patients' sex and stage of the disease. In males the leading factor in sex hormones excretion disorders is a regular decrease both of 17-KS and estrogens, and only in stage UV hyperestrogenization phenomena are observed on account of active estrogens being predominant over androsterone. In females relative hyperestrogenization was observed already in stage III on acount of androsterone decrease, while in stage IV--due to reduction of total 17-KS in normal level of total enstrogens.