ABSTRACT
INTRODUCTION: So far, there is no evidence available to demonstrate the relationship between five subgroups of total cholesterol/high density lipoprotein cholesterol (TC/HDL-C) ratio with premature myocardial infarction (MI). OBJECTIVE: We conducted a case control study to probe more features of the relation between TC/HDL-C ratio and the five subgroups of the ratio with myocardial infarction under 55 years and above it. METHOD: A hospital based case control study with incident cases was designed. Cases and controls were comprised of 523 under 55-year and 699 above 55-year documented newly diagnosed MI cases, respectively. Standardized clinical and para clinical method were used to ascertain disease and risk factors. Independent sample t-test, Pearson chi square test, Odds ratios and Mantel-Haenszel test and logistic regression analysis conducted to evaluate relationships. RESULTS: This study enrolled 1222 MI cases. Patients with very low risk category of TC/HDL-C ratio estimated OR=0.18 with 95% confidence interval (CI) (0.04-0.72) for developing MI under 55 years. Patients who had low risk category of TC/HDL-C ratio having OR=0.26 95% CI (0.07-0.89). Low risk and very low risk categories of the TC/HDL-C ratio compare to high risk subgroup of the ratio demonstrate decreased risk of developing MI under 55 years p<0.05. CONCLUSION: Our study results can be translated as an aggressive treatment for lowering TC/HDL-C ratio in both general population and victims of coronary events. Mitigation of the level of TC/HDL-C ratio from low risk to very low risk category will attenuate the risk of MI under55 years about 8% which is the immediate clinical implication of our findings.
Subject(s)
Adenocarcinoma/drug therapy , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Pancreatic Neoplasms/drug therapy , Adenocarcinoma/diagnosis , Aged , Female , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage , Male , Middle Aged , Outcome Assessment, Health Care/methods , Outcome Assessment, Health Care/statistics & numerical data , Pancreatic Neoplasms/diagnosis , Retrospective Studies , Survival AnalysisSubject(s)
Esophageal Neoplasms/pathology , Esophagogastric Junction , Histiocytic Sarcoma/pathology , Biopsy, Needle , Disease Progression , Esophageal Neoplasms/diagnosis , Esophagoscopy/methods , Fatal Outcome , Histiocytic Sarcoma/diagnosis , Humans , Immunohistochemistry , Male , Middle Aged , Neoplasm Invasiveness/pathology , Neoplasm Staging , Rare Diseases , Tomography, X-Ray Computed/methodsABSTRACT
BACKGROUND: Extensive bowel resection may lead to a state of inadequate nutrient absorption and malnutrition known as short bowel syndrome. Deficiencies in fat-soluble vitamins may occur from this condition, with sequelae such as a bleeding diathesis. Maternal vitamin deficiencies also have been associated with fetal anomalies. CASE: A young gravid patient with a history of neonatal bowel resection presented with bleeding diathesis. She subsequently was found to have profound vitamin deficiencies and delivered a newborn with multiple anomalies. CONCLUSION: Preconceptional counseling, nutritional status evaluation, and concomitant management with a gastroenterologist are essential to optimize pregnancy outcome for patients with a history of extensive bowel resection.
Subject(s)
Abnormalities, Multiple/etiology , Pregnancy Complications , Short Bowel Syndrome/complications , Vitamin K Deficiency Bleeding/etiology , Adult , Disease Susceptibility/etiology , Female , Hematuria/etiology , Humans , Hydrocephalus/etiology , Infant, Newborn , Intestinal Obstruction/complications , Pregnancy , Pregnancy Complications/etiology , Ribs/abnormalities , Vitamin K Deficiency Bleeding/drug therapy , Vitamins/therapeutic useABSTRACT
Primary Ewing sarcoma of the kidney is a very rare neoplasm that generally occurs in young adults. We report a 69-year-old woman with a history of breast cancer who on a routine annual bone scan was found to have a suspicious area over the right kidney. Computed tomography revealed a 16 by 15-cm mass that was removed by a radical nephrectomy. Pathologic examination confirmed the diagnosis of Ewing sarcoma. Three months later, the patient developed recurrence of the tumor at the nephrectomy site that significantly regressed after chemotherapy.
