Subject(s)
Central Nervous System/pathology , Encephalomyelitis, Autoimmune, Experimental/therapy , Endometrium/pathology , Mesenchymal Stem Cell Transplantation , Mesenchymal Stem Cells/physiology , Adipogenesis , Animals , Antigens, CD/metabolism , Cells, Cultured , Central Nervous System/immunology , Encephalomyelitis, Autoimmune, Experimental/immunology , Encephalomyelitis, Autoimmune, Experimental/pathology , Female , Forkhead Transcription Factors/metabolism , Gene Expression , Humans , Inflammation , Interleukin-10/genetics , Interleukin-10/metabolism , Interleukins/genetics , Interleukins/metabolism , Mesenchymal Stem Cells/metabolism , Mice , Mice, Inbred C57BL , Phenotype , Th1 Cells/pathology , Th17 Cells/pathologyABSTRACT
Twenty-five patients with congenital uterovaginal agenesis underwent neovaginoplasty according to the McIndoe and Banister technique. In 17 (68.0%) cases the congenital agensis was also associated with renal and bone malformations. The postoperative results, based on the length of the neovagina, were considered to be satisfactory in 16 (64.0%) cases, moderate in five (20.0%) and fair in four (16.0%). Dehiscences, fistulae and retention cysts were observed in six (24.0%) cases but had no statistically significant correlation with the final length of the neovagina. On the other hand, a statistically significant relationship between the length of the neovagina and dyspareunia was observed.
Subject(s)
Genitalia, Female/abnormalities , Vagina/surgery , Adolescent , Adult , Female , Humans , Middle Aged , SyndromeSubject(s)
Liver Diseases/blood , Platelet Aggregation , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
Os autores analisaram a eficacia do danazol, administrado por via oral nas doses de 400 mg e 600 mg/dia em pacientes inferteis com endometriose pelvica. Os sintomas mais comuns foram dismenorreia (55,0%) algia pelvica cronica (40,0%) e tumor anexial (30,0%). A amenorreia farmacologica e de importante valor prognostico, traduzindo a eficacia do tratamento. No esquema de 400 mg/dia, o indice global de resposta sintomatologica foi de 87,5%; de 600 mg/ dia, de 75.0%. Obteve-se gestacao em 9 (47,4%) das 19 enfermas desejosas de engravidar e o intervalo de tempo medio entre o termino da terapeutica e a gravidez foi de 2,9 meses. Por fim, a ocorrencia de gestacao em pacientes com endometriose pelvica, nesta casuistica, nao guardou relacao com o tempo de esterilidade previa.O periodo de seguimento foi de cinco anos em todos os casos