ABSTRACT
2nd generation assays are currently available to determine the concentration of thyrotropin receptor antibody (TRAb) present in Graves' disease. The aim of this study was to evaluate the analytical performance of TRAb assay on Elecsys 2010 and Cobas(R)e of Roche Diagnostics, a new test using electrochemiluminescence immunoassay (ECLIA). The analytical performance observed with this assay is accurate (repetability and reproductibility, analytical and functional sensitivities). Comparing this method with Brahms' assay (TRAK human RIA), the correlation observed can be put in the equation: y = 1.013 x + 1.381; r = 0.92. With a positive value in ECLIA at 0.9 UI/L and at 1 UI/L in RIA (functional sensitivity fixed by manufacturers), concordance study shows a false negative and two false positive. With a positive value at 0.8 UI/L with ECLIA (functional sensitivity calculated from precision's profile for a CV inferior to 10%), there is no false negative and two false-positive results, this value seems to give a better sensitivity.
Subject(s)
Antibodies/blood , Graves Disease/diagnosis , Immunoassay/methods , Receptors, Thyrotropin/immunology , Graves Disease/blood , Graves Disease/immunology , Humans , Predictive Value of Tests , Sensitivity and SpecificityABSTRACT
Se describe en este relato,la historia clínica de un caso de quiste no parasitario del bazo,intervenido quirúrgicamente en la actividad primaria.Se destaca la escasa frecuencia de su presentación y se efectuarán consideraciones en cuanto a la etiología,el diagnóstico,el cual se puede realizar con exámenes no invasivos, y al tratamiento quirúrgico,planteando la alternativa de la cirugía conservadora versus la exéresis total
Subject(s)
Splenic DiseasesABSTRACT
Se describe en este relato,la historia clínica de un caso de quiste no parasitario del bazo,intervenido quirúrgicamente en la actividad primaria.Se destaca la escasa frecuencia de su presentación y se efectuarán consideraciones en cuanto a la etiología,el diagnóstico,el cual se puede realizar con exámenes no invasivos, y al tratamiento quirúrgico,planteando la alternativa de la cirugía conservadora versus la exéresis total