ABSTRACT
Although it has long been known that mitochondria possess a complex molecular repertoire for accumulating and releasing Ca2+, only in recent years has a large body of data demonstrated that these organelles promptly respond to Ca(2+)-mediated cell stimulations. In this contribution, we will review the principles of mitochondrial Ca2+ homeostasis and its signaling role in different physiological and pathological conditions.
Subject(s)
Apoptosis/physiology , Calcium Channels/metabolism , Calcium/metabolism , Homeostasis/physiology , Mitochondria/physiology , Biological Transport/physiology , Calcium/physiology , Calcium Channels/physiology , Calcium Signaling/physiology , Humans , Intracellular Membranes/metabolism , Intracellular Membranes/physiologyABSTRACT
Although it has long been known that mitochondria possess a complex molecular repertoire for accumulating and releasing Ca2+, only in recent years has a large body of data demonstrated that these organelles promptly respond to Ca2+-mediated cell stimulations. In this contribution, we will review the principles of mitochondrial Ca2+ homeostasis and its signaling role in different physiological and pathological conditions.