ABSTRACT
Barrett's esophagus is considered as a predictor of esophageal adenocarcinoma with multistage neoplastic progression at present time. The research assessed an expression of microRNA-21 in 25 patients with different degree of metaplasia and dysplasia of mucous coat of esophagus. The level of expression of microRNA depended on the presence and degree of expression of neoplastic changes of mucous coat of esophagus. The expression rising of microRNA was noted in patients with columnar-celled metaplasia and intraepithelial neoplasia and in case of esophageal adenocarcinoma. The treatment strategy could be determined by the method of estimation of the level of microRNA expression in biopsy material from mucous coat of esophagus in patients with gastroesophageal reflux disease and using other criteria.
Subject(s)
Adenocarcinoma , Barrett Esophagus , Esophageal Neoplasms , Gastroesophageal Reflux , MicroRNAs , Precancerous Conditions , Adenocarcinoma/genetics , Adenocarcinoma/pathology , Barrett Esophagus/genetics , Barrett Esophagus/pathology , Esophageal Neoplasms/genetics , Esophageal Neoplasms/pathology , Female , Gastroesophageal Reflux/genetics , Gastroesophageal Reflux/pathology , Gene Expression , Genetic Markers , Humans , Male , MicroRNAs/analysis , MicroRNAs/genetics , Middle Aged , Neoplasm Grading , Neoplasm Staging , Precancerous Conditions/genetics , Precancerous Conditions/pathology , Predictive Value of TestsABSTRACT
The bariatric surgery is the most effective way of obesity treatment. The article describes an experience of placement of intragastric balloon as an additional method of treatment to diet and medicamentous therapy in one group of patients. At the same time, there was the other group, where intragstric balloons were placed before bariatric surgery as measure of preoperative preparation.
Subject(s)
Bariatric Surgery/methods , Gastric Balloon , Metabolic Syndrome/therapy , Obesity/therapy , Weight Loss , Body Mass Index , Humans , Metabolic Syndrome/complications , Obesity/complications , Retrospective StudiesABSTRACT
The article is devoted to investigation of the Helicobacter pylori (HP) infection in 14 patients after resection of the stomach for ulcers of the gastroduodenal zone. Different methods were used for the assessment of the state of the gastric stump and gastroenteric anastomosis in the postoperative period. In most cases different degree of inflammatory alterations of the gastric mucosa were detected. In 2 cases (14.3%) peptic ulcers of the anastomosis developed. Changes to the gastric stump of 11 patients were associated with the HP infection which involved the mucosa of the anastomosed intestine in 8 patients. The data obtained point to possible participation of HP pathogenesis of the alterations detected after the stomach resection. The question of the expediency of a specific antibacterial therapy in the postoperative period and in treatment of certain kinds of postgastroresectional syndromes is raised.