ABSTRACT
El objetivo de investigación es describir el estigma y discri-minación atravesadas por personas viviendo con VIH y su relación con el conocimiento y ejercicio de los derechos que los protegen.Las fuentes son el índice de estigma en personas viviendo con VIH en Argentina realizado a través de encuestas de opinión. Para observar su tratamiento, también se relevan artículos periodísticos referidos a la ley que protege los derechos de las personas viviendo con VIH.El nivel de conocimiento de la ley o declaración de compromiso so-bre VIH no se relaciona con experiencia de estigma. En cambio, cuan-to menor es el nivel de conocimiento de derechos, mayor es la canti-dad de experiencias vividas.La apropiación de derechos a través del conocimiento de leyes y de-claraciones que los protegen incide sobre la intención de conseguir re-paraciones legales como sobre intentos de gestiones con agentes gu-bernamentales y/o políticos en pos de su defensa
The research objective is to describe stigma and discrimination traversed by people living with HIV and their relationship with the knowledge and exercise of the rights that protect them. The sources are the stigma index in people living with HIV in Argentina made through opinion polls. To observe their treatment, newspaper articles on the law that protects the rights of people living with HIV are also relieved. The level of knowledge of the law or declaration of commitment on HIV is not related to experience stigma. Instead, the lower the level of awareness of rights , the greater the amount of experiences. The appropriation of rights through knowledge of laws and declarations that protect falls on the intention of getting legal redress and on attempts arrangements with governmental and / or politicians after his defense agents
Subject(s)
Humans , Male , Female , Surveys and Questionnaires , HIV , Social Stigma , Social Discrimination , Right to HealthABSTRACT
Ante la demanda de la comunidad de personas que viven con VIH exigiendo una transformación social a nivel grlobal, ONUSIDA y sus asociados internacionales ICW Global, IPPF, GNP+ proponen investigar este fenómeno del estigma y la discriminación con información basada en la evidencia para determinar sus causas y percepciones y desarrollar más y mejores intervenciones estructurales basadas en los derechos para reducir la estigmatización y la discriminación. En nuestro país se invita a la Red de Personas Viviendo con VIH/Sida de Mar del Plata y a la Fundación Huesped, para que, potenciando sus capacidades y saberes, tomen a su cargo esta tarea.
Subject(s)
Humans , Prejudice , Social Stigma , Stereotyping , Argentina , HIVABSTRACT
Aún cuando los microbicidas constituyen una esperanza para reducir la feminización de la epidemia de VIH/sida mediante el autocuidado de las mujeres en las relaciones sexuales, poco se conoce sobre la aceptabilidad e intención de uso de las mujeres argentinas...
Although there is great hope that microbicides will reduce the feminization of the HIV epidemic through female self-protection in sexual intercourse, little is known about the acceptability and willingness of Argentinean women to use them...
Subject(s)
Humans , Female , Adolescent , Adult , Anti-Infective Agents/therapeutic use , Self Care/methods , Self Care/psychology , Coitus , Condoms, Female , Sex Education/statistics & numerical data , Interviews as Topic/methods , Feminine Hygiene Products , Reproductive Health Services/statistics & numerical dataABSTRACT
Aún cuando los microbicidas constituyen una esperanza para reducir la feminización de la epidemia de VIH/sida mediante el autocuidado de las mujeres en las relaciones sexuales, poco se conoce sobre la aceptabilidad e intención de uso de las mujeres argentinas...(AU)
Although there is great hope that microbicides will reduce the feminization of the HIV epidemic through female self-protection in sexual intercourse, little is known about the acceptability and willingness of Argentinean women to use them...(AU)
Subject(s)
Humans , Female , Adolescent , Adult , Anti-Infective Agents/therapeutic use , Coitus , Self Care/methods , Self Care/psychology , Condoms, Female , Interviews as Topic/methods , Sex Education/statistics & numerical data , Reproductive Health Services/statistics & numerical data , Feminine Hygiene ProductsABSTRACT
BACKGROUND: Based on in vitro studies, Rho guanine nucleotide exchange factors (RhoGEFs) are key regulators of mitogenic and transforming pathways. At least 1 family member, PDZ-RhoGEF, also integrates signaling between monomeric Rho G proteins and heterotrimeric G proteins through a so-called regulator of G-protein signaling (RGS) domain. Recently, the authors reported that 3 single-nucleotide polymorphisms (SNPs) in 2 members of the RGS family were associated with significant reductions in the risk of cancer. METHODS: For the current report, the authors studied the risk of lung cancer associated with a nonsynonymous SNP (rs868188; Ser1416Gly) in PDZ-RhoGEF in a large lung cancer case-control study of 2260 Caucasians and 369 Mexican Americans. RESULTS: Compared with individuals who had the wild-type genotype (AA), Mexican Americans with the variant genotypes (AG and GG) had a significantly reduced risk for lung cancer (odds ratio [OR], 0.57; 95% confidence interval [95%CI], 0.34-0.94). The protective effect appeared to be more evident in younger individuals (OR, 0.42; 95%CI, 0.20-0.91), men (OR, 0.36; 95%CI, 0.18-0.71), and ever smokers (OR, 0.50; 95%CI, 0.29-0.88). A joint effect was observed between Ser1416Gly and polymorphisms in 2 cell-cycle control genes: p53 (intron 3) and cyclin D1 (CCND1). Tallying the variant alleles of the 4 RGS gene SNPs, a gene-dosage effect was apparent. Compared with individuals who had < 3 variant alleles, patients with > or = 3 variant alleles had a 51% reduction in lung cancer risk (OR, 0.49; 95%CI, 0.28-0.88). CONCLUSIONS: To the authors' knowledge, this is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk. The results suggest that there are interactions between RGS2, RGS6, and PDZ-RhoGEF and validate this family of proteins as key regulators of tumorigenesis.