Subject(s)
Ethics, Clinical , Global Health , Judgment , Morals , Decision Making/ethics , Global Health/ethics , Humans , Judgment/ethicsSubject(s)
Attitude to Health , Heuristics , Physician-Patient Relations , Science , Vaccination Refusal/psychology , Adult , COVID-19 Vaccines , Female , Humans , Male , TrustABSTRACT
A racemic and scalable enantioselective total synthesis of (+)-waihoensene was accomplished. (+)-Waihoensene belongs to the diterpene natural product family, and it features an angular triquinane substructure motif. Its tetracyclic [6.5.5.5]backbone is all-cis-fused, containing six contiguous stereocenters, four of which are quaternary. These structural features were efficiently installed by means of a diastereoselective radical cyclization, followed by an intramolecular Pauson-Khand reaction, a diastereoselective α-alkylation, and a diastereoselective 1,4-addition reaction. Enantioselectivity was introduced at an early stage, by an asymmetric palladium catalyzed decarboxylative allylation reaction on gram scale.
Subject(s)
Coronavirus Infections/prevention & control , Health Promotion/methods , Health Risk Behaviors , Masks , Pandemics/prevention & control , Pneumonia, Viral/prevention & control , Science , Trust , COVID-19 , Economics , Humans , Interpersonal Relations , Personal Autonomy , Politics , Social Class , United StatesABSTRACT
Microcarriers with the ability to release and catch substances are highly desired metamaterials and difficult to obtain. Herein, we report a straightforward strategy to synthesize these materials by combining silica-biomorphs with mesocrystals. An easy access to microcarrier hulls with covalently bound spiropyrans as light-switchable anchor points is presented.