Hearing loss is a common side effect of many tumor treatments. However, hearing loss can also occur as a direct result of certain tumors of the nervous system, the most common of which are the vestibular schwannomas (VS). These tumors arise from Schwann cells of the vestibulocochlear nerve and their main cause is the loss of function of NF2, with 95 % of cases being sporadic and 5 % being part of the rare neurofibromatosis type 2 (NF2)-related Schwannomatosis. Genetic variations in NF2 do not fully explain the clinical heterogeneity of VS, and interactions between Schwann cells and their microenvironment appear to be critical for tumor development. Preclinical in vitro and in vivo models of VS are needed to develop prognostic biomarkers and targeted therapies. In addition to VS, other tumors can affect hearing. Meningiomas and other masses in the cerebellopontine angle can compress the vestibulocochlear nerve due to their anatomic proximity. Gliomas can disrupt several neurological functions, including hearing; in fact, glioblastoma multiforme, the most aggressive subtype, may exhibit early symptoms of auditory alterations. Besides, treatments for high-grade tumors, including chemotherapy or radiotherapy, as well as incomplete resections, can induce long-term auditory dysfunction. Because hearing loss can have an irreversible and dramatic impact on quality of life, it should be considered in the clinical management plan of patients with tumors, and monitored throughout the course of the disease.
Hearing Loss , Hearing , Neuroma, Acoustic , Humans , Neuroma, Acoustic/pathology , Neuroma, Acoustic/physiopathology , Neuroma, Acoustic/complications , Hearing Loss/physiopathology , Hearing Loss/etiology , Hearing Loss/pathology , Animals , Neurilemmoma/pathology , Neurilemmoma/complications , Neurilemmoma/therapy , Vestibulocochlear Nerve/pathology , Vestibulocochlear Nerve/physiopathology , Risk Factors , Neurofibromatosis 2/genetics , Neurofibromatosis 2/complications , Neurofibromatosis 2/pathology , Neurofibromatosis 2/physiopathology , Neurofibromatosis 2/therapy , Meningioma/pathology , Meningioma/physiopathology , Meningioma/complications
BACKGROUND AND OBJECTIVE: Nodal metastases in the central compartment are frequent in papillary thyroid cancer (PTC). However, they are mostly micrometastases with no impact on survival and their relevance on the risk of locoregional relapse is controversial. There is no consensus regarding optimal management of the central neck in patients with PTC cN0. In our center, we do not perform prophylactic central neck dissection (pCND). The objective of this study is to review our long-term results and compare them with the most recent literature. PATIENTS AND METHODS: Retrospective review of patients with PTC who underwent total thyroidectomy (TT) without CND between 2005 and 2017. Primary result was disease-free survival in the neck (DFS). RESULTS: 321 patients were identified, mostly T1-T2 tumors (94.1%). Median follow-up was 90 months. DFS in the central compartment was excellent (96.1% at 10 year's follow-up). 19 patients had cervical recurrence, of which 15 underwent salvage surgery. On their last visit, including salvage surgery when appropriate, 77% of patients had excellent response, 18.7% had indeterminate response, 3.1% had biochemically incomplete response and 1.2% had morphologically incomplete response. Recurrent laryngeal nerve (RLN) paralysis after TT was transient in 4.7% of patients and permanent in 0.9% of patients. There were no RLN paralysis after salvage surgery. Permanent hypoparathyroidism occurred in 3.4% of patients. Only one patient had hypoparathyroidism after salvage surgery and it was permanent. CONCLUSIONS: Based on long-term results and low rate of complications associated with salvage surgery in our experience, we consider routine pCND is not justified.
PURPOSE: Achromobacter xylosoxidans is an emerging pathogen mainly associated with resistant nosocomial infections. This bacteria had been isolated in the ear together with other pathogens in cultures from patients with chronic otitis media, but it had never been reported as a cause of osteomyelitis of the external auditory canal. CASE PRESENTATION: We present a unique case of a healthy 81-year-old woman who presented with left chronic otorrhea refractory to topical and oral antibiotic treatment. Otomicroscopy revealed an erythematous and exudative external auditory canal (EAC) with scant otorrhea. The tympanic membrane was intact, but an area of bone remodeling with a small cavity anterior and inferior to the bony tympanic frame was observed. Otic culture isolated multi-drug-resistant A. xylosoxidans, only sensitive to meropenem and cotrimoxazole. Temporal bone computed tomography showed an excavation of the floor of the EAC compatible with osteomyelitis. Targeted antibiotherapy for 12 weeks was conducted, with subsequent resolution of symptoms and no progression of the bone erosion. CONCLUSIONS: Atypical pathogens such as A. xylosoxidans can be the cause of chronic otitis externa. Early diagnosis and specific antibiotherapy can prevent the development of further complications, such as osteomyelitis. In these cases, otic cultures play an essential role to identify the causal germ. This is the first case of EAC osteomyelitis due to A. xylosoxidans reported to date.
Achromobacter denitrificans , Ear Diseases , Osteomyelitis , Otitis Externa , Female , Humans , Aged, 80 and over , Ear Canal/diagnostic imaging , Otitis Externa/diagnosis , Otitis Externa/drug therapy , Osteomyelitis/diagnosis , Osteomyelitis/drug therapy , Osteomyelitis/complications
La cistectomía radical tipo Bricker es un proceso quirúrgico que consiste en la extirpación de la vejiga con la derivación de orina al exterior a través de una urostomía.Exponemos el caso de una paciente con diagnóstico de tumor vesical infiltrante. Se le practica dicho procedimiento y posterior reintervención por obstrucción intestinal con resección de íleon terminal.Presenta un estoma bien delimitado con buena coloración. Tras la segunda intervención surge un pliegue cutáneo que dificulta la adhesión del dispositivo, con la consecuente fuga del efluente, desencadenando como complicación una dermatitis periestomal irritativa.Realizamos una valoración basada en los patrones de M. Gordon, identificamos aquellos que son disfuncionales y formulamos diagnósticos enfermeros según la taxonomía NANDA.Para la resolución del problema, seleccionamos los dispositivos y accesorios más adecuados para conseguir una mejora en la calidad de vida de la paciente
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Humans , Female , Middle Aged , Urinary Bladder Neoplasms/surgery , Dermatitis/etiology , Dermatitis/nursing , Cystectomy/adverse effects , Cystectomy/nursing
El trabajo discute el papel pedagógico de las biografías en la Introducción a la Medicina y Metodología Científica. Concluimos que es un complemento didáctico interesante en el conjunto del proceso educativo, si bien su uso exclusivo es insuficiente para proporcionar una visión de conjunto sobre los conocimientos y las prácticas médicas a lo largo de la historia en su triple dimensión: científica, social y cultural
This paper discuss the didactic role of biographical method for the subject Introduction to Medicine and Scientific Methodology. We suggest to use medical biographies as a complementary tool of global training process, although an exclusively use of this is inadequate to provide an integrated view, as well scientific as social or cultural approaching, about the medical knowledge and practive in the past
Methods , Health Knowledge, Attitudes, Practice , Cultural Characteristics , Education/history , Education, Medical/history , Social Adjustment , Social Alienation , Social Behavior , Social Environment , Social Identification
