A Strep A vaccine global demand and return on investment forecast to inform industry research and development prioritization.

Investment in Strep A vaccine R&D is disproportionately low relative to the large burden of Strep A diseases globally. This study presents a novel Strep A vaccine global demand and financial forecast model with estimates of potential global demand and associated revenue and profits for a hypothetical Strep A vaccine as well as a net present value (NPV) analysis of return on capital investments required to develop the vaccine. A positive NPV was calculated for a variety of developer scenarios and target populations, including the global rollout of the vaccine in private and public markets by a multinational pharmaceutical corporation and a staged rollout by a developing country vaccine manufacturer for both infant and child populations. The results suggest there is a viable commercial market for a Strep A vaccine. It is hoped that this study will help to inform industry decision-making and drive increased prioritization of, and investment in, Strep A vaccine research and development.

Changes in social support predict emotional well-being in breast cancer survivors.

BACKGROUND: Breast cancer survivors who have completed surgery and adjuvant treatment have distinct social support needs that may relate to emotional health. There is little research on both levels of social support following treatment and the association between social support and emotional well-being over time following breast cancer diagnosis and treatment. The aims of this study were to assess (1) the direction and magnitude of change in social support quality and quantity and (2) the degree to which change in quality and quantity of social support predicted change in emotional well-being over time following completion of breast cancer treatment. METHODS: A sample of 157 female breast cancer survivors (Mage = 55, SD = 11 years) completed a baseline and a 1-year follow-up questionnaire assessing sociodemographic information, quality and quantity of social support, and emotional well-being including depression symptoms, stress, and positive and negative affect. RESULTS: Social support quantity significantly decreased over 1 year, while social support quality remained stable. Based on change score analyses, a decrease in social support quality was a significant predictor of increases in depression, stress, and negative affect, explaining an extra 4 to 6% of variance in the emotional well-being outcomes compared with social support quantity. CONCLUSIONS: This study highlights the decline in social support among recently treated female breast cancer survivors and the importance of maintaining high-quality social support for emotional well-being. Copyright © 2016 John Wiley & Sons, Ltd.

Exploring the prevalence and correlates of meeting health behaviour guidelines among university students.

OBJECTIVE: To examine the prevalence of students meeting physical activity, diet and smoking health recommendations and to examine the correlates of meeting these guidelines. METHODS: Randomly selected students at the University of Toronto (N = 2,812; female = 71.60%, mean age = 22.11 ± 5.24 years, mean body mass index = 22.80 kg/m2) completed the National College Health Assessment-II survey in spring of 2013. RESULTS: Only 0.1% of the sample reported meeting physical activity, diet and non-smoking guidelines. Males were more likely than females to meet physical activity and both physical activity and fruit and vegetable guidelines (X2 [1, 2812] = 7.33, p < 0.05). Women were more likely than men to be nonsmokers (X2 [1, 2812] = 7.80, p < 0.05). Being overweight was associated with meeting physical activity guidelines. Being a healthy weight was associated with meeting both physical activity and fruit and vegetable guidelines (X2 [1, 2812] = 6.29, p < 0.05). Underweight participants were more likely to be nonsmokers (X2 [2, 2812] = 6.36, p < 0.05). In the logistic regression, being Caucasian and male and trying to change weight were correlated with meeting moderate-to-vigorous physical activity and strength training guidelines. Being older, Caucasian and trying to change weight were correlates of consuming greater than five fruits and vegetables per day. Beings Caucasian, female, and trying to change weight were correlates of being a non-smoker. CONCLUSION: University health promotion programs should be targeted to specific age, ethnicity and weight status groups, as there are distinct differences among those not meeting physical activity, diet and non-smoking guidelines.

MoveU? Assessing a Social Marketing Campaign to Promote Physical Activity.

OBJECTIVE: MoveU is a social marketing initiative aimed at increasing moderate-to-vigorous physical activity (MVPA) among undergraduate students. Using the Hierarchy of Effects model (HOEM), this study identified awareness of MoveU and examined associations between awareness, outcome expectations, self-efficacy, intentions, and MVPA. PARTICIPANTS: Students (N = 2,784) from a Canadian university in March 2013. METHODS: A secondary analysis of the National College Health Assessment-II survey and measures specific to the MoveU campaign. The main associations were examined in a path analysis. RESULTS: MoveU awareness (36.4%) was lower than other well-established university health campaigns. Younger students, females, and individuals living on campus were more likely to be aware of MoveU. The HOEM was supported, and improvements in model fit were evident, with additional direct relationships between outcome expectancy and intention, and between self-efficacy and MVPA. CONCLUSIONS: The intended population was aware of the campaign. The HOEM was useful in the development and evaluation of the MoveU campaign. Longitudinal studies are needed to further test the efficacy of the HOEM in the social marketing of physical activity.

Physical activity motivation mediates the association between depression symptoms and moderate-to-vigorous physical activity.

OBJECTIVE: To test if motivational regulations (i.e., amotivation, external, introjected, identified, and intrinsic) mediate the association between depression symptoms and moderate-to-vigorous physical activity (MVPA) in young adults. METHOD: A total of 319 young adults from Montreal, Quebec participating in the Nicotine Dependence in Teens (NDIT) study provided self-report data on depression symptoms at age 20 (SD=0.7 years) and motivational regulations at age 24 (SD=0.7 years). MVPA was assessed using a self-report questionnaire at age 20 (i.e., at the same time motivation was measured) and using accelerometers one month later. Multiple mediation analysis with bootstrapping was employed to analyze the data. RESULTS: Controlling for age, sex and self-reported MVPA at age 20 years; introjected regulation was a significant mediator of the association between depression symptoms and MVPA (R(2) adj=0.12; point estimate=-0.0011; BCa CI=-0.15 to -0.01). CONCLUSION: Depression symptoms may undermine controlling forms of motivation, resulting in decreased MVPA. Intervention strategies may be needed to address depression symptoms in young adults to promote sustained MVPA.