1.
Org Lett
; 24(40): 7421-7427, 2022 Oct 14.
Article
in English
| MEDLINE
| ID: mdl-36190804
ABSTRACT
The replacement of α(CH2) by NH in monomers of standard aeg PNA and its homologue ß-ala PNA leads to respective aza-PNA monomers (1 and 2) in which the NαH can form either an 8-membered H-bonded ring with folding of the backbone (DMSO and water) or a 5-membered NαHâαCO (water) to stabilize E-type rotamers. Such aza-PNA oligomers with exclusive E rotamers and intraresidue backbone H-bonding can modulate its DNA/RNA binding and assembling properties.