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Indian J Ophthalmol ; 72(5): 617-619, 2024 May 01.
Article in English | MEDLINE | ID: mdl-38661271

ABSTRACT

Bevacizumab is a monoclonal, humanized, full-length antibody targeting vascular endothelial growth factor(VEGF-A), known for its anti-angiogenic properties. The off-label use of bevacizumab has stirred legal, financial, industrial, and ethical complexities. With its potential to treat diverse ocular conditions, this commentary delves into the multifaceted dimensions of bevacizumab's off-label utilization, encompassing clinical trials, regulatory frameworks, safety considerations, comparative effectiveness, and economic implications.


Subject(s)
Angiogenesis Inhibitors , Antibodies, Monoclonal, Humanized , Bevacizumab , Intravitreal Injections , Off-Label Use , Vascular Endothelial Growth Factor A , Humans , Angiogenesis Inhibitors/administration & dosage , Angiogenesis Inhibitors/therapeutic use , Antibodies, Monoclonal, Humanized/therapeutic use , Bevacizumab/administration & dosage , Bevacizumab/therapeutic use , Global Health , Vascular Endothelial Growth Factor A/antagonists & inhibitors
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