ABSTRACT
Several studies have found that trust in government is associated with social fairness, citizens' satisfaction with public service, and life satisfaction. This study aimed to investigate the serial mediation effects of social security satisfaction and life satisfaction on the association between social security fairness and trust in government. We analyzed the data from the Chinese Social Survey in 2019 (n = 7403) to examine the serial mediation effects. The findings showed that the higher the level of government, the greater the trust it enjoyed from its citizens. The direct prediction of trust by social security fairness was stronger at the county and township levels than at the central government level. Both social security satisfaction and life satisfaction partially mediated the relationship between social security fairness and overall trust in government. Social security fairness indirectly positively predicted trust in local government at the county and township levels through social security satisfaction, life satisfaction, and their serial mediation. While social security fairness could only indirectly predict trust in central government through social security satisfaction, the prediction of trust in central government via life satisfaction (mediator) was not significant. We observed a serial mediation model in which social security fairness positively predicted trust in government directly and indirectly through social security satisfaction and life satisfaction. The finding that social security satisfaction partially mediates the relationship between perceptions of fairness in the social security system and trust in government has implications for improving policies and the functioning of the system at all levels of the government.
Subject(s)
Social Security , Trust , Government , Income , Personal SatisfactionABSTRACT
Colorectal cancer (CRC) is one of the major causes of cancer deaths in the world. 5-fluorouracil (5-FU) -based chemotherapy is a common choice for patients with CRC; unfortunately, the benefit is rather limited due to the acquisition of drug resistance. Therefore, the alternative therapeutic strategies are required. The activation of autophagic mechanism was considered as the main cause of the acquisition of drug resistance in 5-FU treatment. Docosahexaenoic acid (DHA), a fatty acid, has been regarded as an efficient anticancer agent and can improve the drug resistance in conventional cancer therapy by a low basal level of autophagy in colon cancer cells. Moreover, removal of iron or copper by metal chelators could cause ROS levels increase and mediate cancer cell cytotoxicity led by autophagy. In the present study, we constructed a combination of 5-FU, 1:1 mixture of metal chelators di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone hydrochloride (DpC) and N, N, N', N'-tetrakis-[2-pyridylmethyl]-ethylenediamine (TPEN) named DTN, and DHA to evaluate the anticancer effect of this combination, compared to the traditional 5-FU-based chemotherapy; further we investigated the underlying mechanism. Through inducing ROS-mediated degradation of Mcl-1 ubiquitination, the triple combination of 5-FU, DTN and DHA resulted in the elevated apoptosis in CRC cells, thus to reduce the tumor size and weight. Taken together, this study suggests the triple combination of 5-FU+DTN+DHA exhibits an effective anticancer activity of overcoming drug resistance in colorectal cancer, mechanism as the elevated apoptosis mediated by an increase of ROS and Mcl-1 ubiquitination, may be a novel strategy for clinical colon cancer treatment.
ABSTRACT
PURPOSE: E3 ubiquitin ligase ZNRF3 is linked to the pathogenesis of diseases and tumorigenesis. The present study aims to explore the expression of ZNRF3 and its association with prognostic survival of human colorectal carcinoma. METHODS: A follow-up survey of 168 patients with colorectal carcinoma was performed, and specimens of colorectal tissues were collected for immunohistochemistry and Western blotting analyses. Furthermore, overexpression of ZNRF3 using transient transfection with the recombinant pEGFP-ZNRF3 plasmid and detection of apoptosis and proliferation were performed in HCT-116 cells. RESULTS: The results showed a diverse feature of ZNRF3 staining, such as strong, moderate, weak, or negative, in colorectal carcinoma tissues. Interestingly, univariate Kaplan-Meier analysis showed that cases with strong or moderate expression of ZNRF3 showed an optimistic disease-free survival and overall survival compared with negative expression of ZNRF3, and multivariate Cox model demonstrated ZNRF3 as an independent prediction index for overall survival and disease-free survival. In vitro, the overexpression of ZNRF3 was related to the negative regulation of Wnt/ß-catenin pathway and referred to an induction of apoptosis and suppression of proliferation in ZNRF3-transfected HCT-116 cells. CONCLUSION: Our results suggest that the higher expression of ZNRF3 acts as a novel marker of indicating the optimistic prognosis of colorectal carcinoma by suppressing cancer cell growth and facilitating apoptosis.