Pilomatricoma, formerly known as calcifying epithelioma of Malherbe, is a rare, benign, annexic skin tumor developed from the cells of the pilar matrix. The cure without recurrence is the rule after complete surgical excision. Clinical diagnosis is challenging. Actually, differential diagnosis include malignant pilomatricoma or trichomatrical carcinoma with significant aggressive potential. However, the diagnosis of pilomatricoma must remain clinical and be confirmed histologically. We report the rare case of a pilomatricoma, in an unusual location in the thigh.
Carcinoma , Hair Diseases , Pilomatrixoma , Skin Neoplasms , Humans , Pilomatrixoma/diagnosis , Pilomatrixoma/surgery , Pilomatrixoma/pathology , Thigh , Skin Neoplasms/diagnosis , Skin Neoplasms/surgery , Skin Neoplasms/pathology , Hair Diseases/diagnosis , Hair Diseases/surgery , Hair Diseases/pathology , Diagnosis, Differential , Carcinoma/diagnosis
Hidradenitis is a chronic benign pathology with acute manifestations, mainly occurring among young patients with hyper seborrhea. Its clinical presentation is an inflammatory, nodular and fistulized aspect. It affects many body parts, making its location a referral criterion for diagnosis. Our patient had, indeed, a clinical aspect of hidradenitis. However, pathology revealed that it is tuberculosis lymphadenitis.
Hidradenitis Suppurativa , Tuberculosis, Lymph Node , Humans , Lymph Nodes/pathology , Axilla/pathology , Tuberculosis, Lymph Node/diagnosis , Tuberculosis, Lymph Node/pathology , Hidradenitis Suppurativa/diagnosis , Hidradenitis Suppurativa/pathology , Diagnosis, Differential
During the COVID-19 pandemic, the effectiveness of the combination of hydroxychloroquine and azithromycin is widely discussed. This treatment can cause many severe cardiac side effects that makes us discuss its utility. The aim of this study is to describe the cardiovascular effect of hydroxychloroquine and azithromycin by analyzing surface ECG in patients with COVID-19. This observational cohort study included Moroccan patients with COVID-19 diagnosis and were hospitalized in Cheikh Khalifa International University Hospital, Casablanca, Morocco between March 26 and April 20, 2020. Patients were treated with a combination of hydroxychloroquine and azithromycin over a period of at least ten days. We were interested in the effects of this combination on the electrocardiogram. A total of 118 eligible patients were enrolled in the study. QT interval prolongation was observed in 19% of patients under the treatment. Only 5 patients required discontinuation of treatment. The factors associated with QT prolongation are male gender (P value 0,043), age over 68 years (P value 0,09), cardiovascular comorbidity (P value 0,013), tisdale score ≥11 (P value < 0,001), and a severe form of COVID-19 (P value < 0,001). First degree atrioventricular block was observed in 2 patients. No serious rhythm or conduction disorders were observed in this study. QT prolongation is a real risk with the combination of hydroxychloroquine and azithromycin. In the current context, it is necessary to select patients at high risk of severe rhythm disturbances that require closer ECG monitoring. Treatment should be discontinued if there are alarming signs such as QTc prolongation beyond 550 ms and the development of ventricular extrasystole or torsade de pointe.
