The impact of COVID-19 pandemic in patients with a diagnosis of Oral Lichen Planus: Pain perception and psychological profile analysis.

OBJECTIVES: To assess the impact of COVID-19 in patients affected by OLP, in terms of level of pain, stress, depression and anxiety and their impact on the clinical manifestation of the disease. MATERIAL AND METHODS: A longitudinal design was employed. Psychometric evaluations of anxiety, stress, and depression were conducted using the DASS21 scale, while pain levels were measured using the VAS scale. Clinical diagnosis and phenotype evaluation were performed. RESULTS: The study included 24 patients with an average age of 62.9 years, with 70.8% presenting erosive OLP. Results revealed a significant worsening of anxiety, stress, and depression scores during the pandemic. Pain level (1.5 ± 1.2 pre-pandemic VS 3.8 ± 1.1 during the pandemic, p < 0.0001) was also negatively affected. CONCLUSIONS: These findings highlight the potential interplay between psychological stress and oral health conditions, emphasizing the need for a comprehensive understanding of OLP's complex etiology and its response to external stressors. CLINICAL RELEVANCE: Multidisciplinary care strategies to address both physical and psychological aspects of OLP patients is recommended following the present findings. Further research is warranted to confirm these observations in larger multicenter studies and to guide tailored guidance approaches for OLP patients during challenging times.

Accuracy and Security Analysis of a Cranio-Maxillofacial Plastic Surgery Robot Equipped With Piezosurgery in Genioplasty.

ABSTRACT: This study aims to verify that the craniofacial plastic surgery robot with piezosurgery is more accurate and safer than traditional operations in genioplasty. This study chose data from the Digital Plastic Surgery of Plastic Surgery Hospital in the Chinese Academy of Medical Sciences and Peking Union Medical College. The CT data of the patient's skull were reconstructed in the software, and the authors designed the measurement index. The surgical plan was designed as an ideal scheme (control group). Patients underwent traditional surgery according to the preoperative surgery plan (clinical group). Guided by surgical navigation, the osteotomy was operated on patients' same size plaster model using the surgery robot equipped with a piezosurgery (robot group). At last, the accuracy was calculated by CT data. There was no significant difference between the robotic group and control groups in the postoperative measurement index (P < 0.05). There was no significant difference between the robotic group and the control group ( P > 0.05) in the line of osteotomy, but there was a significant difference between the clinical group and the control group in the line of the osteotomy.

A new framework to identify dental emergencies in the COVID-19 era.

In order to reduce the spread of COVID-19 (Coronavirus Disease 2019), it is crucial to take extraordinary prevention and safety measures in dental offices, and to defer all elective and non-urgent procedures. Dental emergencies are defined through oral symptoms but, the systemic and psychological conditions of each patient should be considered. The present short communication proposes a multilevel evaluation (oral, systemic and psychological) and risk assessment score for the management of dental emergencies following the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) outbreak. A comprehensive categorization and score scale assessment for dental emergencies allows a better identification of patient's treatment needs and avoids unnecessary contact between dental health care providers and patients during the SARS-CoV-2 pandemic.

A metabolomic study of preterm and term human and formula milk by proton MRS analysis: preliminary results.

OBJECTIVE: To investigate changes in global metabolic profile between: 1 - breast milk and formula milk, 2 - breast milk from mothers delivering at different gestational age (GA) collected within one week from delivery, and then week by week until term equivalent age. METHODS: Proton magnetic resonance spectroscopy (MRS) was used to analyze the water-soluble and lipid fractions extracted from 50 milk samples, 46 human milk at different GA, from 23 weeks of gestation until term equivalent age and four different formula milks. RESULTS: The formula milk for premature infants was the most similar to breast milk of preterm babies. Breast milk showed higher lactose concentrations than formula milk, that conversely presented higher galactose 1-phosphate and maltose concentrations. Mother's milk of very preterm babies (23-25 wks of GA) showed a different metabolic profile from preterm infants ≥29 wks of GA with a subsequent trend to similarity around the 30th week of post-natal age. Breast milk from preterm infants of 29-34 wks, collected up to 40 wks of post-natal age showed a temporal change over the first three weeks of lactation, approaching to zero with the achievement of term age. CONCLUSIONS: Metabolome is a promising tool to study human and artificial milk global metabolic profile.

Glaucoma e inflamación ocular / Glaucoma and ocular inflammation

El glaucoma se asocia con frecuencia a ceguera irreversible, y puede verse asociado a inflamación en casi todas sus variedades, como uveítis anterior, coroidorretinitis, queratitis o escleritis. Puede ser de difícil manejo y se requiere del conocimiento profundo de la fisiopatología del cuerpo ciliar y malla trabecular para su oportuno tratamiento. Éste conlleva tanto la necesidad de tratar la enfermedad asociada, como el manejo de antiinflamatorios e incluso cirugía. Muchos casos de glaucoma son refractarios a las medidas terapéuticas convencionales, por lo que puede ser necesario el uso de antimetabolitos o de implantes valvulares.

Retinopatía en pacientes diabéticos tratados por diferentes especialistas. Reporte preliminar / Retinopathy in diabetics seen by different specialists

Se realizó un estudio retrospectivo para determinar si existen diferentes proporciones de pacientes con retinopatía en grupos manejados por diferentes especialistas médicos.Material y método: Las valoraciones oftalmológicas iniciales de pacientes diabéticos se dividieron de acuerdo al médico que los refirió: grupo 1: endocrinólogos; grupo 2: médicos internistas; y grupo 3: médicos generales. Se comparó la proporción de ojos con: a) retinopatía diabética, b) retinopatía proliferativa y c) pérdida visual severa. Se valoró también la oportunidad de la detección de acuerdo con las recomendaciones internacionales. Las diferencias entre cada grupo se analizaron mediante x2.Resultados: Se valoraron 756 ojos de 387 pacientes. Se asignaron 264 ojos al grupo 1, 152 al grupo 2 y 340 al grupo 3. La proporción general de ojos con retinopatía, con retinopatía proliferativa y con pérdida visual severa fue de 48 por ciento, 16 por ciento y 14 por ciento respectivamente. La presencia de retinopatía diabética, retinopatía proliferativa y pérdida visual severa fue significativamente menor para el grupo 1 al compararlo con los grupos 2 y 3 (p < 0.05), pero las diferencias entre los grupos 2 y 3 no fueron significativas (p > 0.05). La detección no fue oportuna para ninguno de los grupos.Discusión: Debe reforzarse la práctica de la detección de retinopatía por el médico que maneja al paciente diabético y la referencia oportuna para calificación, especialmente durante la formación de pregrado.