Hippotherapy acute impact on heart rate variability non-linear dynamics in neurological disorders.

Neurological disorders are associated with autonomic dysfunction. Hippotherapy (HT) is a therapy treatment strategy that utilizes a horse in an interdisciplinary approach for the physical and mental rehabilitation of people with physical, mental and/or psychological disabilities. However, no studies have been carried out which evaluated the effects of HT on the autonomic control in these patients. Therefore, the objective of the present study was to investigate the effects of a single HT session on cardiovascular autonomic control by time domain and non-linear analysis of heart rate variability (HRV). The HRV signal was recorded continuously in twelve children affected by neurological disorders during a HT session, consisting in a 10-minute sitting position rest (P1), a 15-minute preparatory phase sitting on the horse (P2), a 15-minute HT session (P3) and a final 10-minute sitting position recovery (P4). Time domain and non-linear HRV indices, including Sample Entropy (SampEn), Lempel-Ziv Complexity (LZC) and Detrended Fluctuation Analysis (DFA), were calculated for each treatment phase. We observed that SampEn increased during P3 (SampEn=0.56±0.10) with respect to P1 (SampEn=0.40±0.14, p<0.05), while DFA decreased during P3 (DFA=1.10±0.10) with respect to P1 (DFA=1.26±0.14, p<0.05). A significant SDRR increase (p<0.05) was observed during the recovery period P4 (SDRR=50±30ms) with respect to the HT session period P3 (SDRR=30±10ms). Our results suggest that HT might benefit children with disabilities attributable to neurological disorders by eliciting an acute autonomic response during the therapy and during the recovery period.

Correlation between autonomous function and left ventricular performance after acute myocardial infarction.

Reduced ejection fraction (EF), possibly induced/mediated by autonomic abnormal activation, is one of the most powerful predictors of adverse outcome after acute myocardial infarction (MI). A deep understanding of the correlation between the autonomous functionality and the left ventricular performance in these patients is therefore of paramount importance. The autonomous function is reflected in the cardiac activity and, specifically, in the heart rate variability (HRV) signal. Given the cardiac activity nonlinearity, growing interest is being manifested towards nonlinear methods of analysis, which might provide more significant information than the traditional linear approaches. The aim of the present study was to investigate if non-linear HRV metrics change between MI patients with preserved EF (pEF) and MI patients with reduced EF (rEF). Data were acquired in the context of the cardioRisk project. Ten MI patients with rEF and six MI patients with pEF, admitted to Intensive Cardiac Care after a first acute MI episode, were studied. The ECG was acquired during a Holter recording and the tachogram was extracted. Sample entropy (SE) and Lempel-Ziv Complexity (LZC 1 and LZC 2) metrics were computed on five hour long tachogram portions. A significant correlation was found between LZC indices and EF in the whole population; SE, LZC 1 and LZC 2 were significantly higher in patients with pEF. Our results indicate that lower complexity characterizes the HRV of MI patients with rEF. Complexity reduction might be due to a simplification of regulatory mechanisms, which might explain why MI patients with rEF are at higher risk for subsequent non-fatal and fatal events.