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J Pediatr ; 154(2): 303-5, 2009 Feb.
Article in English | MEDLINE | ID: mdl-19150680

ABSTRACT

Survival motor neuron (SMN) messenger RNA and protein levels in spinal muscular atrophy (SMA) model mice and in patients with SMA were measured. There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a moderate correlation between leukocyte SMN expression and age of disease onset in patients with SMA.


Subject(s)
Leukocytes/metabolism , Muscular Atrophy, Spinal/metabolism , SMN Complex Proteins/metabolism , Spinal Cord/metabolism , Adult , Age of Onset , Animals , Female , Humans , Male , Mice , Muscular Atrophy, Spinal/classification , RNA, Messenger/metabolism , Reverse Transcriptase Polymerase Chain Reaction
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